Paroxetine ( DrugBank: Paroxetine )

4 diseases

ID	Disease name (Link within this page)	Number of trials
6	Parkinson disease	2
13	Multiple sclerosis/Neuromyelitis optica	1
46	Malignant rheumatoid arthritis	7
85	Idiopathic interstitial pneumonia	1

6. Parkinson disease

Clinical trials : 2,307 / Drugs : 2,007 - (DrugBank : 349) / Drug target genes : 188 - Drug target pathways : 199

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00086190 (ClinicalTrials.gov)	June 2005	28/6/2004	Study of Antidepressants in Parkinson's Disease	Study of Antidepressants in Parkinson's Disease	Parkinson Disease;Depression	Drug: paroxetine;Drug: venlafaxine;Other: placebo	University of Rochester	National Institute of Neurological Disorders and Stroke (NINDS)	Completed	30 Years	N/A	All	115	Phase 3	United States;Canada;Puerto Rico
2	NCT00062738 (ClinicalTrials.gov)	June 2003	12/6/2003	Treatment of Depression in Parkinson's Disease Trial	Treatment of Depression in Patients With Parkinson's Disease	Parkinson Disease;Depression	Drug: paroxetine;Drug: Nortriptyline;Other: placebo	Rutgers, The State University of New Jersey	GlaxoSmithKline	Completed	35 Years	80 Years	All	52	Phase 2	United States

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13. Multiple sclerosis/Neuromyelitis optica

Clinical trials : 3,340 / Drugs : 2,163 - (DrugBank : 383) / Drug target genes : 241 - Drug target pathways : 238

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00291148 (ClinicalTrials.gov)	March 2006	10/2/2006	Neuropathic Pain Assessment Comparing Pregabalin and Paroxetinein Management of MS-induced Neuropath ...	A Comparative Single Center, Randomized Neuropathic Pain Assessment Study Involving Patients With Cl ...	Neuropathic Pain;Multiple Sclerosis	Drug: paroxetine;Drug: pregabalin;Drug: Paroxetine	University of Manitoba	NULL	Completed	18 Years	65 Years	Both	75	Phase 3	Canada

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46. Malignant rheumatoid arthritis

Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04757571 (ClinicalTrials.gov)	February 1, 2021	12/2/2021	The GRK2 Inhibitor Paroxetineas a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Pati ...	The GRK2 Inhibitor Paroxetineas a Novel Adjunct to Conventional Therapy in Rheumatoid Arthritis Pati ...	Rheumatoid Arthritis	Drug: Paroxetine;Drug: Placebo	Sadat City University	NULL	Recruiting	18 Years	60 Years	All	120	Phase 1/Phase 2	Egypt
2	EUCTR2004-004995-35-DK (EUCTR)	10/04/2006	20/09/2005	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	ACTIVE RHEUMATOID ARTHRITIS	Product Name: N/A Product Code: CRx-139 INN or Proposed INN: Paroxetine & Prednisolone	CombinatoRx, Inc.	NULL	Not Recruiting			Female: yes Male: yes	220	Phase 2	Czech Republic;Germany;United Kingdom;Denmark;Italy
3	EUCTR2004-004995-35-GB (EUCTR)	24/02/2006	16/03/2005	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	ACTIVE RHEUMATOID ARTHRITIS	Trade Name: Paroxetinehydrochloride 10 & 20 mg and Prednisolone 1 mg BP Product Name: N/A Product Code ...	CombinatoRx, Inc.	NULL	Not Recruiting			Female: yes Male: yes	220	Phase 2	Czech Republic;Austria;Denmark;Germany;Italy;United Kingdom
4	EUCTR2004-004995-35-IT (EUCTR)	08/11/2005	02/02/2007	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	Evaluate the difference in ACR-20 response between rheumatoid arthritis subjects treated with each o ...	INN or Proposed INN: Paroxetine INN or Proposed INN: Paroxetine Trade Name: Prednisolene tablets BP 1 ...	COMBINATORX, INC	NULL	Not Recruiting			Female: yes Male: yes	220	Phase 2	Czech Republic;Austria;Denmark;Germany;United Kingdom;Italy
5	EUCTR2004-004995-35-AT (EUCTR)	16/10/2005	09/11/2005	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	ACTIVE RHEUMATOID ARTHRITIS	Trade Name: ParoxetineHydrochloride tablets 10 & 20 mg and Prednisolone 1 mg BP Product Name: N/A Prod ...	CombinatoRx, Inc.	NULL	Not Recruiting			Female: yes Male: yes	220	Phase 2	Czech Republic;Denmark;Austria;Germany;Italy;United Kingdom
6	EUCTR2004-004995-35-CZ (EUCTR)	30/08/2005	30/08/2005	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	ACTIVE RHEUMATOID ARTHRITIS	Trade Name: Prednisolone Tablets BP 1 mg Product Name: N/A Product Code: CRx-139 INN or Proposed INN: P ...	CombinatoRx, Inc.	NULL	Not Recruiting			Female: yes Male: yes	220	Phase 2	Germany;United Kingdom;Czech Republic;Denmark;Italy
7	EUCTR2004-004995-35-DE (EUCTR)	14/07/2005	17/03/2005	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	A PHASE II MULTI-CENTER, RANDOMIZED, BLINDED STUDY OF 14 WEEKS DURATION COMPARING THE EFFECT OF CRx- ...	ACTIVE RHEUMATOID ARTHRITIS	Product Name: N/A Product Code: CRx-139 INN or Proposed INN: Paroxetine Product Name: N/A Product Code: ...	CombinatoRx, Inc.	NULL	Not Recruiting			Female: yes Male: yes	220	Phase 2	Czech Republic;United Kingdom;Germany;Denmark;Italy

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85. Idiopathic interstitial pneumonia

Clinical trials : 627 / Drugs : 443 - (DrugBank : 120) / Drug target genes : 99 - Drug target pathways : 212

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04888728 (ClinicalTrials.gov)	June 30, 2021	28/4/2021	To Evaluate Drug-drug Interactions Between DWN12088 and Nebivolol or Paroxetinein Healthy Volunteers ...	An Open Label, 2-part, One-sequence, 3-period Study to Evaluate Drug-drug Interactions Between DWN12 ...	Idiopathic Pulmonary Fibrosis	Drug: DWN12088;Drug: Nebivolol;Drug: Paroxetine	Daewoong Pharmaceutical Co. LTD.	NULL	Completed	20 Years	55 Years	Male	24	Phase 1	Korea, Republic of

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