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e.g. Sirolimus, Adalimumab

ABCDEFGH I JKLMNOPQRSTUVWXYZother

46 / 17,542 descriptions

No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes		 Disease ID
 1  Acitretin  Acitretin  [1] D02754 💬  [5] RARA, RARB, RXRA, RXRB, RXRG 💬  [17] Acute myeloid leukemia, Adipocytokine signaling pathway, Bile secretion, Estrogen signaling pathway, Gastric cancer, Hepatitis C, Non-alcoholic fatty liver disease, Non-small cell lung cancer, PI3K-Akt signaling pathway, PPAR signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer  [1] 37 💬 
 2  Adalimumab  Adalimumab  [1] D02597 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [16] 19, 37, 40, 41, 46, 56, 84, 96, 97, 151, 160, 164, 222, 226, 269, 271 💬 
 3  Ain457  -  -  -  -  [7] 13, 37, 41, 46, 56, 96, 271 💬 
 4  Ain457, 150mg  -  -  -  -  [1] 37 💬 
 5  Alefacept  Alefacept  [1] D02800 💬  [1] CD58 💬  [2] Cell adhesion molecules, Epstein-Barr virus infection  [6] 37, 60, 65, 164, 284, 285 💬 
 6  Alvarez 2  -  -  -  -  [1] 37 💬 
 7  Anakinra  Anakinra  [1] D02934 💬  [2] IL1R1, IL1R2 💬  [15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer  [17]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 84, 86, 97, 106, 107, 299 💬 
 8  Anb019  -  -  -  -  [1] 37 💬 
 9  Anti-il-36r monoclonal antibody  -  -  -  -  [1] 37 💬 
 10  Bi 655130  -  -  -  -  [3] 37, 96, 97 💬 
 11  Bi655130  -  -  -  -  [1] 37 💬 
 12  Brodalumab  Brodalumab  [1] D10061 💬  [1] IL17RA 💬  [2] Cytokine-cytokine receptor interaction, IL-17 signaling pathway  [2] 37, 51 💬 
 13  Brodalumab 210mg sc  Brodalumab  [1] D10061 💬  [1] IL17RA 💬  [2] Cytokine-cytokine receptor interaction, IL-17 signaling pathway  [1] 37 💬 
 14  Calcitriol  Calcitriol  [1] D00129 💬  [1] VDR 💬  [4] Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Parathyroid hormone synthesis, secretion and action, Tuberculosis  [8] 37, 46, 49, 66, 96, 158, 235, 326 💬 
 15  Certolizumab pegol  Certolizumab pegol  [1] D03441 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [6] 37, 46, 96, 97, 226, 271 💬 
 16  Cnto1959  -  -  -  -  [3] 37, 96, 97 💬 
 17  Efalizumab  Efalizumab  [1] D03959 💬  [1] ITGAL 💬  [12] Cell adhesion molecules, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Leukocyte transendothelial migration, Malaria, Natural killer cell mediated cytotoxicity, Neutrophil extracellular trap formation, Rap1 signaling pathway, Regulation of actin cytoskeleton, Rheumatoid arthritis, Staphylococcus aureus infection, Viral myocarditis  [8] 11, 13, 37, 46, 53, 61, 95, 96 💬 
 18  Guselkumab  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [4] 37, 41, 96, 97 💬 
 19  Guselkumab 100 mg  Guselkumab  [1] D10438 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [1] 37 💬 
 20  Infliximab  Infliximab  [1] D02598 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [24] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 95, 96, 97, 98, 162, 164, 269, 271 💬 
 21  Infliximab [infliximab biosimilar 3]  Infliximab  [1] D02598 💬  [1] TNF 💬  [65] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway  [4] 37, 46, 96, 97 💬 
 22  Ixekizumab  Ixekizumab  [1] D10071 💬  [1] IL17A 💬  [5] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation  [5] 36, 37, 162, 269, 271 💬 
 23  Khk4827  -  -  -  -  [2] 37, 51 💬 
 24  Khk4827 140mg sc  -  -  -  -  [1] 37 💬 
 25  Khk4827 210mg sc  -  -  -  -  [1] 37 💬 
 26  Ly3074828  -  -  -  -  [3] 37, 96, 97 💬 
 27  Mirikizumab  Mirikizumab  [1] D11123 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [3] 37, 96, 97 💬 
 28  Monoclonal antibody anti-igg1  -  -  -  -  [3] 37, 96, 97 💬 
 29  Null  -  -  -  -  [16]  6 , 13, 15, 28, 37, 46, 49, 51, 63, 86, 90, 96, 97, 107, 145, 271 💬 
 30  P32  -  -  -  -  [1] 37 💬 
 31  P32/98  -  -  -  -  [1] 37 💬 
 32  P32/98 3%  -  -  -  -  [1] 37 💬 
 33  Placebo  -  -  -  -  [26]  3 ,  5 ,  6 , 13, 14, 37, 40, 46, 49, 50, 51, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬 
 34  Raptiva  -  -  -  -  [9] 11, 13, 37, 46, 49, 53, 61, 95, 96 💬 
 35  Risankizumab  Risankizumab  [1] D11052 💬  [1] IL23A 💬  [9] C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis  [4] 37, 96, 97, 271 💬 
 36  Secukinumab  Secukinumab  [1] D09967 💬  [1] IL17A 💬  [5] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation  [7] 13, 37, 41, 46, 160, 269, 271 💬 
 37  Secukinumab 150 mg/1 ml solution for injection  Secukinumab  [1] D09967 💬  [1] IL17A 💬  [5] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation  [2] 37, 271 💬 
 38  Secukinumab 150mg  Secukinumab  [1] D09967 💬  [1] IL17A 💬  [5] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation  [1] 37 💬 
 39  Secukinumab 300mg  Secukinumab  [1] D09967 💬  [1] IL17A 💬  [5] Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation  [1] 37 💬 
 40  Silikis 3µg/g salbe  -  -  -  -  [1] 37 💬 
 41  Spesolimab  Spesolimab  -  -  -  [3] 37, 96, 97 💬 
 42  Ta-650  -  -  -  -  [4] 37, 56, 96, 97 💬 
 43  Tg  -  -  -  -  [2] 13, 37 💬 
 44  Tremfya  -  -  -  -  [2] 37, 97 💬 
 45  Tremfya®  -  -  -  -  [2] 37, 97 💬 
 46  Ustekinumab  Ustekinumab  [1] D09214 💬  [3] IL12A, IL12B, IL23A 💬  [26] African trypanosomiasis, Allograft rejection, Amoebiasis, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Legionellosis, Leishmaniasis, Malaria, Measles, Pathways in cancer, Pertussis, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus  [15] 37, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 162, 269, 271 💬 

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