Drug    DrugBank | All Description Patterns💬 Info on mouse-over

No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	0 mg prednisone	Prednisone	[1] D00473 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 44 💬
2	5 mg prednisone	Prednisone	[1] D00473 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[1] 44 💬
3	Abatacept	Abatacept	[1] D03203 💬	[2] CD80, CD86 💬	[12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	[26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300 💬
4	Abatacept (ctla4-ig)	Abatacept	[1] D03203 💬	[2] CD80, CD86 💬	[12] Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis	[1] 44 💬
5	Alemtuzumab	Alemtuzumab	[1] D02802 💬	-	-	[16] 13, 15, 19, 20, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284 💬
6	Avacopan	Avacopan	[1] D11093 💬	[1] C5AR1 💬	[5] Complement and coagulation cascades, Coronavirus disease - COVID-19, Neuroactive ligand-receptor interaction, Neutrophil extracellular trap formation, Staphylococcus aureus infection	[4] 43, 44, 222, 223 💬
7	Azathioprin-ratiopharm® 25 mg filmtabletten	-	-	-	-	[1] 44 💬
8	Azathioprine	Azathioprine	[2] D00238, D03033 💬	-	-	[20]  6 , 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 94, 95, 96, 97, 162 💬
9	Azathioprine 25 mg	Azathioprine	[2] D00238, D03033 💬	-	-	[1] 44 💬
10	Azd7986	-	-	-	-	[2] 44, 299 💬
11	Belimumab	Belimumab	[1] D03068 💬	[1] TNFSF13B 💬	[4] Cytokine-cytokine receptor interaction, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Rheumatoid arthritis	[10] 11, 43, 44, 46, 49, 51, 53, 66, 222, 300 💬
12	Benralizumab	Benralizumab	[1] D09874 💬	[1] IL5RA 💬	[4] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, Pathways in cancer	[4] 44, 45, 98, 162 💬
13	Biological: benralizumab, biological: placebo to mepolizumab	Benralizumab	[2] D04923, D09874 💬	[2] IL5, IL5RA 💬	[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation	[1] 44 💬
14	Biological: mepolizumab, biological: placebo to benralizumab	Benralizumab	[2] D04923, D09874 💬	[2] IL5, IL5RA 💬	[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation	[1] 44 💬
15	Blisibimod	Blisibimod	[1] D10311 💬	-	-	[5] 43, 44, 49, 63, 66 💬
16	Ccx168	-	-	-	-	[6] 43, 44, 66, 109, 222, 223 💬
17	Chimeric monoclonal antibody, igg4 subtype	-	-	-	-	[2] 43, 44 💬
18	Corticosteroid	-	-	-	-	[10] 13, 42, 43, 44, 45, 66, 84, 96, 97, 222 💬
19	Corticosteroid and azathioprine	Azathioprine	[2] D00238, D03033 💬	-	-	[4] 42, 43, 44, 45 💬
20	Cyclophosphamide	Cyclophosphamide	[2] D00287, D07760 💬	-	-	[44] 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331 💬
21	Cyclophosphamide followed by methotrexate (azathioprine) + glucocorticoids or methotrexate (azathioprine) + glucocorticoids	Azathioprine	[6] D00142, D00238, D00287, D02115, D03033, D07760 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 44 💬
22	Cyclophosphamidum	Cyclophosphamide	[2] D00287, D07760 💬	-	-	[1] 44 💬
23	Cyclophosphamidum 500 mg	Cyclophosphamide	[2] D00287, D07760 💬	-	-	[1] 44 💬
24	Endoxan	-	-	-	-	[7] 13, 28, 43, 44, 85, 96, 222 💬
25	Endoxan® 500 mg	-	-	-	-	[1] 44 💬
26	Galen® tablet	-	-	-	-	[2] 43, 44 💬
27	Glucocorticoid (gc)	-	-	-	-	[2] 43, 44 💬
28	Glucocorticoids	-	-	-	-	[8] 40, 41, 43, 44, 60, 62, 75, 300 💬
29	Glucocorticoids (gc)	-	-	-	-	[2] 43, 44 💬
30	Glucocorticoids - reduced dose	-	-	-	-	[2] 43, 44 💬
31	Glucocorticoids - standard dose	-	-	-	-	[2] 43, 44 💬
32	Glucocorticoids [reduced dose]	-	-	-	-	[2] 43, 44 💬
33	Glucocorticoids [standard dose]	-	-	-	-	[2] 43, 44 💬
34	Gusperimus	Gusperimus	[1] D08032 💬	-	-	[1] 44 💬
35	Gusperimus + glucocorticoids	Gusperimus	[1] D08032 💬	-	-	[1] 44 💬
36	Hydroxychloroquine	Hydroxychloroquine	[1] D08050 💬	-	-	[23] 13, 34, 41, 43, 44, 45, 46, 48, 49, 53, 56, 66, 84, 89, 90, 96, 218, 222, 234, 254, 271, 298, 299 💬
37	Ifx-1	-	-	-	-	[3] 43, 44, 269 💬
38	Ins1007	-	-	-	-	[2] 44, 299 💬
39	L04ac06	-	-	-	-	[2] 44, 45 💬
40	Mabthera	-	-	-	-	[22] 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271 💬
41	Mabthera®	-	-	-	-	[6] 13, 35, 43, 44, 46, 93 💬
42	Medi-563	-	-	-	-	[3] 44, 45, 98 💬
43	Mepolizumab	Mepolizumab	[1] D04923 💬	[1] IL5 💬	[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation	[4] 44, 45, 98, 162 💬
44	Mesna	-	-	-	-	[11] 11, 13, 44, 45, 49, 51, 60, 65, 85, 96, 164 💬
45	Metex 2,5 mg tabletten	-	-	-	-	[1] 44 💬
46	Methotrexate	Methotrexate	[2] D00142, D02115 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[35] 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 271, 284, 285, 326, 331 💬
47	Methotrexate 2.5 mg	Methotrexate	[2] D00142, D02115 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 44 💬
48	Methotrexate 25 mg	Methotrexate	[2] D00142, D02115 💬	[2] DHFR, DHFR2 💬	[5] Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate	[1] 44 💬
49	Metoject 10 mg/ml, solution injectable en seringue pré-remplie	-	-	-	-	[1] 44 💬
50	Naltrexone	Naltrexone	[2] D02095, D05113 💬	[3] OPRD1, OPRK1, OPRM1 💬	[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway	[12]  6 , 10, 13, 40, 41, 42, 43, 44, 45, 96, 97, 226 💬
51	Naltrexone hydrochloride	Naltrexone	[2] D02095, D05113 💬	[3] OPRD1, OPRK1, OPRM1 💬	[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway	[8] 10, 40, 41, 42, 43, 44, 45, 96 💬
52	Nucala	-	-	-	-	[2] 44, 45 💬
53	Nucala 100 mg powder for solution for injection	-	-	-	-	[2] 44, 45 💬
54	Orencia	-	-	-	-	[13] 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 160, 222, 271 💬
55	Other: no plasma exchange	-	-	-	-	[2] 43, 44 💬
56	Pednisone	-	-	-	-	[2] 43, 44 💬
57	Plaquenil - hydroxychloroquine 200mg film coated tablets	Hydroxychloroquine	[1] D08050 💬	-	-	[3] 43, 44, 45 💬
58	Prednisolone	Prednisolone	[8] D00472, D00980, D00981, D00982, D01239, D01998, D02156, D03301 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[40] 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
59	Prednison acis® 20 mg	-	-	-	-	[2] 43, 44 💬
60	Prednison acis® 5 mg	-	-	-	-	[2] 43, 44 💬
61	Prednisone	Prednisone	[1] D00473 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[47]  2 ,  6 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 93, 95, 96, 97, 113, 127, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 💬
62	Prednisone tablets, usp	Prednisone	[1] D00473 💬	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction	[3] 41, 43, 44 💬
63	Procedure: plasma exchange	-	-	-	-	[5] 13, 43, 44, 64, 222 💬
64	Recombinant humanized monoclonal antibody specific for human il-5	-	-	-	-	[1] 44 💬
65	Remission induction therapy	-	-	-	-	[2] 43, 44 💬
66	Reslizumab	Reslizumab	[1] D08985 💬	[1] IL5 💬	[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation	[2] 44, 98 💬
67	Rituximab	Rituximab	[1] D02994 💬	[1] MS4A1 💬	[1] Hematopoietic cell lineage	[47] 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
68	Rituximab (arm a)	Rituximab	[1] D02994 💬	[1] MS4A1 💬	[1] Hematopoietic cell lineage	[2] 43, 44 💬
69	Rituximab (arm b)	Rituximab	[1] D02994 💬	[1] MS4A1 💬	[1] Hematopoietic cell lineage	[2] 43, 44 💬
70	Ro0452294/v01	-	-	-	-	[2] 43, 44 💬
71	Ro0452294/v02	-	-	-	-	[3] 35, 43, 44 💬
72	Sb-240563	-	-	-	-	[3] 44, 45, 98 💬
73	Sb-240563 (mepolizumab)	Mepolizumab	[1] D04923 💬	[1] IL5 💬	[13] Allograft rejection, Asthma, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, IL-17 signaling pathway, Inflammatory bowel disease, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Pathways in cancer, T cell receptor signaling pathway, Th1 and Th2 cell differentiation	[2] 44, 45 💬
74	Sulfamethoxazole	Sulfamethoxazole	[1] D00447 💬	-	-	[4] 44, 49, 85, 299 💬
75	Trimethoprim	Trimethoprim	[2] D00145, D06236 💬	-	-	[6] 36, 44, 49, 60, 85, 299 💬
76	Trimethoprim sulfamethoxazole	Sulfamethoxazole	[3] D00145, D00447, D06236 💬	-	-	[1] 44 💬
77	Vitamin d	Vitamin D	-	-	-	[21] 13, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 274, 298, 299 💬
78	Yellow fever vaccine	Yellow Fever Vaccine	[1] D06347 💬	-	-	[7] 40, 44, 46, 50, 51, 52, 53 💬
79	Yellow fever vaccine (17d)	Yellow Fever Vaccine	[1] D06347 💬	-	-	[7] 40, 44, 46, 50, 51, 52, 53 💬

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