Drug    DrugBank | All Description Patterns💬 Info on mouse-over

No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	20 mg sildenafil citrate by mouth	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
2	5% sildenafil cream	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 50 💬
3	Access program - sildenafil citrate, viagra, revatio	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
4	Bosentan and sildenafil	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
5	Duo-therapy with sildenafil + bosentan	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
6	Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan)	Bosentan	[6] D01227, D02008, D02229, D07538, D08514, D10135 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
7	G04be03- sildenafil - sildenafil (citrato)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
8	Mono-therapy with sildenafil	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
9	Oral sildenafil	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
10	Other: standard of care sildenafil	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[2] 90, 301 💬
11	Sildenafil	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
12	Sildenafil (50 mg)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 85 💬
13	Sildenafil (acute-1 hour)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 299 💬
14	Sildenafil (as citrate)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
15	Sildenafil (revatio)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
16	Sildenafil (revatio) 20 mg tid	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
17	Sildenafil (subchronic-4 weeks)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 299 💬
18	Sildenafil 20 mg tablets	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 278 💬
19	Sildenafil 20mg	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[2] 51, 86 💬
20	Sildenafil 20mg and bosentan 62.5mg	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[2] 51, 86 💬
21	Sildenafil 40mg oral capsule	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 299 💬
22	Sildenafil and losartan	Losartan	[4] D00357, D02229, D08146, D08514 💬	[2] AGTR1, PDE5A 💬	[18] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Purine metabolism, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway	[1] 85 💬
23	Sildenafil by injection	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 210 💬
24	Sildenafil citrate	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[4] 51, 85, 86, 225 💬
25	Sildenafil citrate (uk-92,480)	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
26	Sildenafil filmtabletten	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
27	Sildenafil singly or in association with bosentan	Bosentan	[4] D01227, D02229, D07538, D08514 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
28	Sildenafil therapy	Sildenafil	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 51 💬
29	Sitaxsentan and sildenafil	Sildenafil	[3] D02229, D07171, D08514 💬	[2] EDNRA, PDE5A 💬	[9] Calcium signaling pathway, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
30	Sodium tanshinone iia sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth	Dextrose, unspecified form	[2] D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
31	Tadalafil and sildenafil	Sildenafil	[3] D02008, D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 113 💬

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