Drug    DrugBank | All Description Patterns💬 Info on mouse-over

No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Era and pde-5i (sildenafil, tadalafil, bosentan, macitentan)	Bosentan	[6] D01227, D02008, D02229, D07538, D08514, D10135 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
2	Fdc macitentan/tadalafil	Macitentan	[2] D02008, D10135 💬	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[1] 86 💬
3	Tadalafil	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[7]  6 , 51, 75, 84, 86, 113, 210 💬
4	Tadalafil 20 mg	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 113 💬
5	Tadalafil 20 mg film-coated tablets	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
6	Tadalafil 40 mg	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
7	Tadalafil and ambrisentan upfront combination therapy	Ambrisentan	[2] D02008, D07077 💬	[2] EDNRA, PDE5A 💬	[9] Calcium signaling pathway, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway	[2] 51, 86 💬
8	Tadalafil and sildenafil	Sildenafil	[3] D02008, D02229, D08514 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 113 💬
9	Tadalafil citrate	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 210 💬
10	Tadalafil oral suspension	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
11	Tadalafil, placebo	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
12	Tadalafil- tablet or oral suspension	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬
13	Tadalafilo	Tadalafil	[1] D02008 💬	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway	[1] 86 💬