Drug    DrugBank | All Description Patterns💬 Info on mouse-over

No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY On map, Yellow: Drug target genes	Disease ID
1	Amitriptyline, fluoxetine and tramadol alone (control group)	Amitriptyline	[6] D00326, D00809, D00823, D01355, D07448, D08623 💬	[3] OPRM1, SLC6A2, SLC6A4 💬	[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle	[1] 78 💬
2	Sc recombinant growth hormone + amitriptyline, fluoxetine and tramadol (treated group)	Amitriptyline	[7] D00326, D00809, D00823, D01355, D02691, D07448, D08623 💬	[4] GHR, OPRM1, SLC6A2, SLC6A4 💬	[9] Cytokine-cytokine receptor interaction, Estrogen signaling pathway, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Serotonergic synapse, Synaptic vesicle cycle	[1] 78 💬
3	Tramadol	Tramadol	[2] D01355, D08623 💬	[1] OPRM1 💬	[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction	[5] 46, 70, 78, 226, 271 💬
4	Tramadol /acetaminophen	Acetaminophen	[3] D00217, D01355, D08623 💬	[3] OPRM1, PTGS1, PTGS2 💬	[26] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Estrogen signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway	[1] 271 💬
5	Tramadol hydrochloride + acetaminophen	Acetaminophen	[3] D00217, D01355, D08623 💬	[3] OPRM1, PTGS1, PTGS2 💬	[26] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis, Estrogen signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, Morphine addiction, NF-kappa B signaling pathway, Neuroactive ligand-receptor interaction, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway	[1] 46 💬
6	Tramadol with ropivacaine	Ropivacaine	[4] D01355, D04048, D08490, D08623 💬	[6] OPRM1, SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬	[6] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction	[1] 70 💬