Target Gene/Pathway💬 Info on mouse-over

46 / 286 pathways

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank Disease ID
1 African trypanosomiasis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
2 African trypanosomiasis 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
5 Alzheimer disease 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
6 Alzheimer disease 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
7 Amoebiasis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
8 Amoebiasis 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
9 Amoebiasis 💬
[2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
10 Antifolate resistance 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
11 Antifolate resistance 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
12 C-type lectin receptor signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
13 C-type lectin receptor signaling pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
14 Cellular senescence 💬
[1] IL1A 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
15 Chagas disease 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
16 Chagas disease 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
17 Coronavirus disease - COVID-19 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
18 Coronavirus disease - COVID-19 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
19 Cytokine-cytokine receptor interaction 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
20 Cytokine-cytokine receptor interaction 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
21 Cytokine-cytokine receptor interaction 💬
[2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
22 Cytosolic DNA-sensing pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
23 Cytosolic DNA-sensing pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
24 Fluid shear stress and atherosclerosis 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
25 Fluid shear stress and atherosclerosis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
26 Fluid shear stress and atherosclerosis 💬
[2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
27 Graft-versus-host disease 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
28 Graft-versus-host disease 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
29 Hematopoietic cell lineage 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
30 Hematopoietic cell lineage 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
31 Hematopoietic cell lineage 💬
[2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
32 Herpes simplex virus 1 infection 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
33 Herpes simplex virus 1 infection 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
34 Human cytomegalovirus infection 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
35 Human cytomegalovirus infection 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
36 Human cytomegalovirus infection 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
37 Human T-cell leukemia virus 1 infection 💬
[2] IL1R1, IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
38 IL-17 signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
39 IL-17 signaling pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
40 Inflammatory bowel disease 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
41 Inflammatory bowel disease 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
42 Inflammatory mediator regulation of TRP channels 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
43 Inflammatory mediator regulation of TRP channels 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
44 Inflammatory mediator regulation of TRP channels 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
45 Influenza A 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
46 Influenza A 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
47 Legionellosis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
48 Legionellosis 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
49 Leishmaniasis 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
50 Leishmaniasis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
51 Malaria 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
52 Malaria 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
53 MAPK signaling pathway 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
54 MAPK signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
55 MAPK signaling pathway 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
56 Measles 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
57 Measles 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
58 Necroptosis 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
59 Necroptosis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
60 NF-kappa B signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
61 NF-kappa B signaling pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
62 NF-kappa B signaling pathway 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
63 NOD-like receptor signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
64 NOD-like receptor signaling pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
65 Non-alcoholic fatty liver disease 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
66 Non-alcoholic fatty liver disease 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
67 Osteoclast differentiation 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
68 Osteoclast differentiation 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
69 Osteoclast differentiation 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
70 Pathogenic Escherichia coli infection 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
71 Pathogenic Escherichia coli infection 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
72 Pathogenic Escherichia coli infection 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
73 Pathways of neurodegeneration - multiple diseases 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
74 Pathways of neurodegeneration - multiple diseases 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
75 Pertussis 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
76 Pertussis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
77 Prion disease 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
78 Prion disease 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
79 Prostate cancer 💬
[1] IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
80 Rheumatoid arthritis 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
81 Rheumatoid arthritis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
82 Salmonella infection 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
83 Salmonella infection 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
84 Shigellosis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
85 Shigellosis 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
86 Shigellosis 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
87 Th17 cell differentiation 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
88 Th17 cell differentiation 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
89 Th17 cell differentiation 💬
[1] IL1R1 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
90 TNF signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
91 TNF signaling pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
92 Toll-like receptor signaling pathway 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
93 Toll-like receptor signaling pathway 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
94 Transcriptional misregulation in cancer 💬
[1] IL1R2 💬 D02934 💬 Anakinra [19]  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
95 Tuberculosis 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
96 Tuberculosis 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
97 Type I diabetes mellitus 💬
[2] IL1A, IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
98 Type I diabetes mellitus 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
99 Yersinia infection 💬
[1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
100 Yersinia infection 💬
[1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬