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Target Gene/Pathway💬 Info on mouse-over

e.g. Sirolimus, Adalimumab, MAP2K

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59 / 286 pathways

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related		 KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adrenergic signaling in cardiomyocytes 💬
 [5] CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
2 Adrenergic signaling in cardiomyocytes 💬
 [1] KCNQ1 💬 D09569 💬 Ezogabine [2]  2 , 144 💬
3 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D00354 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
4 Adrenergic signaling in cardiomyocytes 💬
 [1] SCN5A 💬 D05775 💬 Rufinamide [1] 144 💬
5 Aldosterone synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
6 Alzheimer disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
7 Amphetamine addiction 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
8 Amphetamine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
9 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
10 Amyotrophic lateral sclerosis 💬
 [2] GRIA1, GRIA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
11 Arrhythmogenic right ventricular cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
12 Bile secretion 💬
 [1] CA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
13 Calcium signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
14 Calcium signaling pathway 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [3] 140, 144, 145 💬
15 cAMP signaling pathway 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
16 cAMP signaling pathway 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
17 Carbohydrate digestion and absorption 💬
 [1] CACNA1D 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
18 Cardiac muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
19 Cellular senescence 💬
 [1] CACNA1D 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
20 cGMP-PKG signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
21 Cholinergic synapse 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
22 Cholinergic synapse 💬
 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 D09569 💬 Ezogabine [2]  2 , 144 💬
23 Circadian entrainment 💬
 [6] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
24 Circadian entrainment 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
25 Circadian entrainment 💬
 [2] MTNR1A, MTNR1B 💬 D08170 💬 Melatonin [11]  6 ,  8 , 13, 46, 49, 90, 97, 144, 145, 149, 202 💬
26 Cocaine addiction 💬
 [1] GRIA2 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
27 Cocaine addiction 💬
 [1] GRIA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
28 Collecting duct acid secretion 💬
 [1] CA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
29 Cortisol synthesis and secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
30 Cushing syndrome 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
31 Dilated cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
32 Dopaminergic synapse 💬
 [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
33 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
34 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00354 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
35 Dopaminergic synapse 💬
 [1] SCN1A 💬 D05775 💬 Rufinamide [1] 144 💬
36 GABAergic synapse 💬
 [20] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
37 GABAergic synapse 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam [2] 140, 144 💬
38 Gap junction 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [3] 140, 144, 145 💬
39 Gastric acid secretion 💬
 [1] CA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
40 Gastric acid secretion 💬
 [1] KCNQ1 💬 D09569 💬 Ezogabine [2]  2 , 144 💬
41 Glutamatergic synapse 💬
 [11] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
42 Glutamatergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
43 GnRH secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
44 GnRH signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
45 Growth hormone synthesis, secretion and action 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
46 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
47 Huntington disease 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
48 Hypertrophic cardiomyopathy 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
49 Inflammatory mediator regulation of TRP channels 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [3] 140, 144, 145 💬
50 Insulin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
51 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
52 Long-term depression 💬
 [3] GRIA1, GRIA2, GRIA3 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
53 Long-term potentiation 💬
 [3] CACNA1C, GRIA1, GRIA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
54 Long-term potentiation 💬
 [2] GRIA1, GRIA2 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
55 MAPK signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
56 Metabolic pathways 💬
 [2] CA2, CA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
57 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam [2] 140, 144 💬
58 Morphine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
59 Neuroactive ligand-receptor interaction 💬
 [2] CNR1, CNR2 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
60 Neuroactive ligand-receptor interaction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam [2] 140, 144 💬
61 Neuroactive ligand-receptor interaction 💬
 [25] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
62 Neuroactive ligand-receptor interaction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
63 Neuroactive ligand-receptor interaction 💬
 [3] HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine [3] 140, 144, 145 💬
64 Neuroactive ligand-receptor interaction 💬
 [2] MTNR1A, MTNR1B 💬 D08170 💬 Melatonin [11]  6 ,  8 , 13, 46, 49, 90, 97, 144, 145, 149, 202 💬
65 Nicotine addiction 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam [2] 140, 144 💬
66 Nicotine addiction 💬
 [20] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
67 Nicotine addiction 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
68 Nitrogen metabolism 💬
 [2] CA2, CA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
69 Oxytocin signaling pathway 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
70 Pancreatic secretion 💬
 [1] CA2 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
71 Pancreatic secretion 💬
 [1] KCNQ1 💬 D09569 💬 Ezogabine [2]  2 , 144 💬
72 Pathways of neurodegeneration - multiple diseases 💬
 [8] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
73 Pathways of neurodegeneration - multiple diseases 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
74 Prion disease 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
75 Protein digestion and absorption 💬
 [1] KCNQ1 💬 D09569 💬 Ezogabine [2]  2 , 144 💬
76 Proximal tubule bicarbonate reclamation 💬
 [2] CA2, CA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
77 Rap1 signaling pathway 💬
 [1] CNR1 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
78 Renin secretion 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
79 Retrograde endocannabinoid signaling 💬
 [24] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
80 Retrograde endocannabinoid signaling 💬
 [1] CNR1 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
81 Retrograde endocannabinoid signaling 💬
 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam [2] 140, 144 💬
82 Retrograde endocannabinoid signaling 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
83 Serotonergic synapse 💬
 [7] CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
84 Serotonergic synapse 💬
 [3] GABRB1, GABRB2, GABRB3 💬 D01253 💬 Clobazam [2] 140, 144 💬
85 Serotonergic synapse 💬
 [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 D07945 💬 Fenfluramine [3] 140, 144, 145 💬
86 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
87 Spinocerebellar ataxia 💬
 [3] GRIA1, GRIA2, GRIA3 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
88 Synaptic vesicle cycle 💬
 [1] SLC6A4 💬 D07945 💬 Fenfluramine [3] 140, 144, 145 💬
89 Taste transduction 💬
 [10] CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
90 Taste transduction 💬
 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D01253 💬 Clobazam [2] 140, 144 💬
91 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D00354 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
92 Taste transduction 💬
 [3] SCN2A, SCN3A, SCN9A 💬 D05775 💬 Rufinamide [1] 144 💬
93 Thermogenesis 💬
 [1] CNR1 💬 D10915 💬 Cannabidiol [19]  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
94 Tight junction 💬
 [1] CACNA1D 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
95 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
96 Transcriptional misregulation in cancer 💬
 [1] GRIA3 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
97 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
98 Vascular smooth muscle contraction 💬
 [4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate [5]  6 , 140, 144, 156, 193 💬
99 Vibrio cholerae infection 💬
 [1] KCNQ1 💬 D09569 💬 Ezogabine [2]  2 , 144 💬

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