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Target Gene/Pathway💬 Info on mouse-over

e.g. Sirolimus, Adalimumab, MAP2K

ABCDEFGH I JKLMNOPQRSTUVWXYZother

66 / 286 pathways

No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related		 KEGG GENES KEGG DRUG DrugBank Disease ID
1 Adipocytokine signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
2 Adipocytokine signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
4 AMPK signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
5 AMPK signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
6 Apelin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
7 Apelin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
8 Autophagy - animal 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
9 Autophagy - animal 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
10 Bladder cancer 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
11 Calcium signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
12 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D02229 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
13 cGMP-PKG signaling pathway 💬
 [1] PDE5A 💬 D08514 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
14 Chagas disease 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
15 Chemical carcinogenesis 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
16 Circadian rhythm 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
17 Circadian rhythm 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
18 Cysteine and methionine metabolism 💬
 [3] DNMT1, DNMT3A, DNMT3B 💬 D03665 💬 Decitabine [4] 13, 63, 90, 301 💬
19 Cytokine-cytokine receptor interaction 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
20 Drug metabolism - cytochrome P450 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
21 EGFR tyrosine kinase inhibitor resistance 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
22 Fatty acid degradation 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
23 Fluid shear stress and atherosclerosis 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
24 Fluid shear stress and atherosclerosis 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
25 Fluid shear stress and atherosclerosis 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
26 Focal adhesion 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
27 FoxO signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
28 FoxO signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
29 Glucagon signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
30 Glucagon signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
31 Glycolysis / Gluconeogenesis 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
32 Herpes simplex virus 1 infection 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
33 HIF-1 signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
34 HIF-1 signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
35 Human cytomegalovirus infection 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
36 Human papillomavirus infection 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
37 Hypertrophic cardiomyopathy 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
38 Hypertrophic cardiomyopathy 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
39 Inflammatory bowel disease 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
40 Influenza A 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
41 Insulin resistance 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
42 Insulin resistance 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
43 Insulin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
44 Insulin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
45 JAK-STAT signaling pathway 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
46 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] IFNGR1 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
47 Kaposi sarcoma-associated herpesvirus infection 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
48 Leishmaniasis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
49 Longevity regulating pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
50 Longevity regulating pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
51 Longevity regulating pathway - multiple species 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
52 Longevity regulating pathway - multiple species 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
53 MAPK signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
54 Metabolic pathways 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
55 Metabolic pathways 💬
 [3] DNMT1, DNMT3A, DNMT3B 💬 D03665 💬 Decitabine [4] 13, 63, 90, 301 💬
56 Metabolic pathways 💬
 [1] PDE5A 💬 D02229 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
57 Metabolic pathways 💬
 [1] PDE5A 💬 D08514 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
58 Metabolism of xenobiotics by cytochrome P450 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
59 MicroRNAs in cancer 💬
 [3] DNMT1, DNMT3A, DNMT3B 💬 D03665 💬 Decitabine [4] 13, 63, 90, 301 💬
60 MicroRNAs in cancer 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
61 mTOR signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
62 mTOR signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
63 Natural killer cell mediated cytotoxicity 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
64 Necroptosis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
65 Non-alcoholic fatty liver disease 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
66 Non-alcoholic fatty liver disease 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
67 Osteoclast differentiation 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
68 Oxytocin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
69 Oxytocin signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
70 Pancreatic cancer 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
71 Pathways in cancer 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
72 Pathways in cancer 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
73 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
74 PI3K-Akt signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
75 PI3K-Akt signaling pathway 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
76 PI3K-Akt signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
77 Proteoglycans in cancer 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
78 Purine metabolism 💬
 [1] PDE5A 💬 D02229 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
79 Purine metabolism 💬
 [1] PDE5A 💬 D08514 💬 Sildenafil [17]  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
80 Pyruvate metabolism 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
81 Rap1 signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
82 Ras signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
83 Relaxin signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
84 Renal cell carcinoma 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
85 Retinol metabolism 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
86 Rheumatoid arthritis 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬
87 Th1 and Th2 cell differentiation 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
88 Th17 cell differentiation 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
89 Thermogenesis 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
90 Thermogenesis 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
91 Tight junction 💬
 [2] PRKAA1, PRKAA2 💬 D00944 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
92 Tight junction 💬
 [2] PRKAA1, PRKAA2 💬 D04966 💬 Metformin [21]  2 ,  6 , 13, 46, 49, 60, 67, 75, 77, 81, 86, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
93 Toxoplasmosis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
94 Tuberculosis 💬
 [2] IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b [7] 18, 65, 85, 228, 299, 301, 326 💬
95 Tyrosine metabolism 💬
 [3] ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole [1] 301 💬
96 VEGF signaling pathway 💬
 [1] VEGFA 💬 D05697 💬 Ranibizumab [4] 34, 166, 227, 301 💬

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