DDrare: Database of Drug Development for Rare Diseases

235. 副甲状腺機能低下症
［臨床試験数：67，薬物数：112（DrugBank：24），標的遺伝子数：4，標的パスウェイ数：5］

Searched query = "Hypoparathyroidism", "Accessory thyroid hypergasia disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 100mcg rhPTH(1-84); 25mcg rhPTH(1-84); 50mcg rhPTH(1-84); A: PTH (1-84); Acetate; Alfacalcidol; Amorphous calcium carbonate; Betamethasone; CLTX-305; Calcitriol; Calcitriol & Calcium; Calcium; Calcium Carbonate; Calcium Citrate; Calcium carbonate; Calcium carbonate and alphacalcidol; Calcium citrate; Calcium gluconate; Calcium lactate; Carbonate; Combination Product: TransCon PTH; Combination product (Natpara) and drug or supplements [Disease and drug registry]; Crystalline calcium supplements; Dexamethasone; Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland).; Diagnostic Test: Postoperative laboratory blood tests at 24 hour; Diagnostic Test: Postoperative laboratory blood tests at 6 hour; Diagnostic Test: Postoperative laboratory drainage fluid tests at 24 hour; Diagnostic Test: Preoparative blood laboratory tests; EB612 (EBP05); ESIDREX-R; ESIDREX-R 25 mg; EnteraBio's Oral Parathyroid Hormone (1-34); Esidrex; Ether; FORSTEO; FORSTEO-R; Forsteo; Human recombinant parathyroid Hormone; Human recombinant parathyroid hormone; Hydrochlorothiazide; INDOCYANINE GREEN; INN Parathyroid Hormone (1-84) human; Immediate post operative bioassay of Parathyroid Hormone; Indocyanine Green; Indocyanine green; Magnesium; NATPARA/NATPAR; NPSP 558; NPSP558; Natpar; Natpara; Open-label PTH(1-84); Other: Empiric use of Calcium Carbonate and Calcitriol; Other: PTH based Calcium Carbonate and Calcitriol repletion; Other: Postoperative nausea and vomiting at 24 hour; Other: Postoperative nausea and vomiting at 6 hour; Other: Postoperative pain at 24 hour; Other: Postoperative pain at 6 hour; Other: Postoperative sore throat and hoarseness at 24 hour; Other: Postoperative sore throat and hoarseness at 6 hour; Other: Serum calcium concentrations results; Other: Symptomatic hypocalcaemia at 24 hour; Other: Symptomatic hypocalcaemia at 6 hour; PARATHYROID HORMONE; PCO371; POLY(OXY-1,2-ETHANEDIYL), A; POLY(OXY-1,2-ETHANEDIYL), ALPHA-HYDRO-OMEGA-METHOXY, ETHER WITH N-[[[2-[[6-[[1-[3-[[3-(2,3-DIHYDROXYPROPOXY)PROPYL]AMINO]-3-OXOPROPYL]-2,5-DIOXO-3-PYRROLIDINYL]THIO]HEXYL]AMINO]ETHYL]AMINO]CARBONYL]-2-METHYLALANYL-TERIPARATIDE (2:1); PREOTACT; PTH; PTH 1-34; PTH1-84 in parent study; Parathyroid; Parathyroid Hormone; Parathyroid Hormone (1-84) Human Recombinant; Parathyroid Hormone (rDNA); Parathyroid hormon 1-84; Parathyroid hormone; Parathyroid hormone (rdna); Parathyroideahormon; Phosphate; Phosphate and betamethasone acetate, 2 mL.; Polyethylene glycol; Potassium; Potassium sparing diuretic; Preotact; Procedure: Total thyroidectomy; RECOMBINANT HUMAN PARATHYROID HORMONE (1-84); Rcombinant Human Parathyroid Hormone [rhPTH(1-84)]; Recombinant Human Parathyroid Hormone [rhPTH(1-84)]; RhPTH; RhPTH (1-84); RhPTH(1-84); SUB21634; Saline 0.9% NaCl; Sevelamer; Sodium citrate; Synthetic Human Parathyroid Hormone 1-34; TERIPARATIDE; Teriparatide; Teriparatide conjugated to a multiarm polyethylene glycol carrier molecule through a cleavable linker; Thiazide; Thymus/Parathyroid Transplantation; TransCon PTH; TransCon PTH high-dose pen; TransCon PTH low-dose pen; TransCon PTH mid-dose pen; Tériparatide; UN-ALPHA-R; UN-ALPHA-R 0.25µg; Verde de Indocianina (Indocyanine Green); Vitamin D

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03425747 (ClinicalTrials.gov)	October 15, 2019	27/1/2018	Efficacy of Calcium Citrate Versus Calcium Carbonate for the Management of Chronic Hypoparathyroidism	CALCIUM CITRATE vs CALCIUM CARBONATE FOR THE MANAGEMENT OF CHRONIC HYPOPARATHYROIDISM	Chronic Hypoparathyroidism	Drug: Calcium Carbonate;Drug: Calcium Citrate	Campus Bio-Medico University	NULL	Completed	18 Years	75 Years	All	26	Phase 4	Italy
2	NCT04126941 (ClinicalTrials.gov)	June 1, 2019	11/10/2019	Monocentric Study on the Use of Teriparatide in Children With hypoparathyroïdism	Bi-daily Injection of Subcutaneous Teriparatide in Children With Hypoparathyroidism: Single-center Experience	Hypoparathyroidism	Other: Serum calcium concentrations results	Hospices Civils de Lyon	NULL	Recruiting	2 Years	18 Years	All	9		France
3	ChiCTR1900022194	2019-04-02	2019-03-30	A prospective randomized controlled trial of different calcium supplementation regimens on the recovery of parathyroid function after thyroid surgery	A prospective randomized controlled trial of different calcium supplementation regimens on the recovery of parathyroid function after thyroid surgery	Hypoparathyroidism	Prophylactic group:Prophylactic calcium and vitamin D supplementation;treatment group:calcium and vitamin Dsupplementation is appropriate for hypocalcemia symptomatic patients;	West China Hospital, Sichuan University	NULL	Recruiting	18	75	Both	Prophylactic group:150;treatment group:150;	N/A	China
4	NCT03249012 (ClinicalTrials.gov)	September 1, 2017	9/8/2017	Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism	Comparing the Quality of Life Associated With Empiric Calcium Repletion and Parathormone (PTH) Based Calcium Repletion for Post Thyroidectomy Hypoparathyroidism	Hypoparathyroidism Postprocedural;Quality of Life	Other: Empiric use of Calcium Carbonate and Calcitriol;Other: PTH based Calcium Carbonate and Calcitriol repletion	CHU de Quebec-Universite Laval	NULL	Recruiting	18 Years	N/A	All	120	N/A	Canada
5	NCT04146259 (ClinicalTrials.gov)	January 1, 2017	29/10/2019	Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism	Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism	Hypoparathyroidism Postprocedural	Drug: calcium carbonate and alphacalcidol	University of Athens	NULL	Completed	19 Years	N/A	Female	109		Greece
No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
6	NCT01815021 (ClinicalTrials.gov)	April 2013	7/3/2013	A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients	A Randomized, Two Phase, Adaptive Then Crossover Open-label, Study Comparing Amorphous Calcium Carbonate (ACC) Supplement Versus Commercially Available Crystalline Calcium Supplements (CCS) in the Management of Primary Hypoparathyroidism.	Hypoparathyroidism	Dietary Supplement: amorphous calcium carbonate;Dietary Supplement: crystalline calcium supplements	Amorphical Ltd.	NULL	Completed	18 Years	80 Years	Both	10	Phase 1;Phase 2	Israel
7	JPRN-UMIN000002155	2009/09/01	06/07/2009	Effects of falecalcitoriol on post-operative hypoparathyroidism after thyroidectomy		Postoperative hypoparathyroidism	In the first day after operation, we start administration of falecalcitriol at a dosage of 0.6ug once a day, when below the lower limit of serum calcium. If serum calcium level do not reach normal range, we escalete to 0.9ug/day.Oral calcium lactate is administered 3g/day in all enrolled patients.The dose is reduced when serum calcium and intact PTH level are maintained within normal range. If subjective symptoms such as tetany are worsen up, we start administration of calcium via DIV.	kawasaki medicak school	NULL	Complete: follow-up complete	Not applicable	Not applicable	Male and Female	30	Phase 3	Japan
8	NCT00824226 (ClinicalTrials.gov)	January 2009	15/1/2009	Magnesium Treatment in Hypoparathyroidism	Effect of Magnesium Treatment on Plasma Calcium in Hypoparathyroid Patients	Hypoparathyroidism	Dietary Supplement: magnesium	University of Tartu	NULL	Completed	18 Years	N/A	Both	10	N/A	Estonia
9	JPRN-UMIN000000475	2006/07/01	01/09/2006	Therapeutic strategy of relative hypoparathyroidism in hemodialysis patients using sevelamer hydrochloride, with special reference to vitamin D administration		Relative hypoparathyoidism in maintenance hemodialysis patients	Replacement of calcium carbonate with sevelamer hydrochloride as phosphate binder	Hokusetsu ROD Study Group	NULL	Complete: follow-up complete	20years-old	Not applicable	Male and Female	40	Not applicable	Japan
10	NCT00581828 (ClinicalTrials.gov)	January 2005	19/12/2007	Does Treatment of Hypovitaminosis D Increase Calcium Absorption?	Does Treatment of Hypovitaminosis D Increase Calcium Absorption?	Osteoporosis;Osteopenia;Vitamin D Deficiency;Hypoparathyroidism;Hypercalciuria;Hypercalcemia	Drug: Vitamin D	University of Wisconsin, Madison	NULL	Completed	N/A	N/A	Female	19	Phase 4	United States
No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
11	NCT00004361 (ClinicalTrials.gov)	July 1995	18/10/1999	Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects		Hypoparathyroidism;Tetralogy of Fallot;Pulmonary Valve Stenosis;Conotruncal Cardiac Defects;Heart Defects, Congenital;Pulmonary Atresia	Drug: calcium gluconate;Drug: sodium citrate	National Center for Research Resources (NCRR)	Ann & Robert H Lurie Children's Hospital of Chicago	Completed	18 Years	N/A	Both	150	N/A	NULL
12	NCT00001304 (ClinicalTrials.gov)	October 1991	3/11/1999	Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34	Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34	Hypoparathyroidism	Drug: Synthetic Human Parathyroid Hormone 1-34;Drug: Calcitriol & Calcium	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	NULL	Completed	17 Years	69 Years	All	27	Phase 2	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT03425747
(ClinicalTrials.gov)

October 15, 2019

27/1/2018

Efficacy of Calcium Citrate Versus Calcium Carbonate for the Management of Chronic Hypoparathyroidism

CALCIUM CITRATE vs CALCIUM CARBONATE FOR THE MANAGEMENT OF CHRONIC HYPOPARATHYROIDISM

Chronic Hypoparathyroidism

Drug: Calcium Carbonate;Drug: Calcium Citrate

Campus Bio-Medico University

NULL

Completed

18 Years

75 Years

All

Phase 4

Italy

NCT04126941
(ClinicalTrials.gov)

June 1, 2019

11/10/2019

Monocentric Study on the Use of Teriparatide in Children With hypoparathyroïdism

Bi-daily Injection of Subcutaneous Teriparatide in Children With Hypoparathyroidism: Single-center Experience

Hypoparathyroidism

Other: Serum calcium concentrations results

Hospices Civils de Lyon

NULL

Recruiting

2 Years

18 Years

All

France

ChiCTR1900022194

2019-04-02

2019-03-30

A prospective randomized controlled trial of different calcium supplementation regimens on the recovery of parathyroid function after thyroid surgery

Hypoparathyroidism

Prophylactic group:Prophylactic calcium and vitamin D supplementation;treatment group:calcium and vitamin Dsupplementation is appropriate for hypocalcemia symptomatic patients;

West China Hospital, Sichuan University

NULL

Recruiting

Both

Prophylactic group:150;treatment group:150;

N/A

China

NCT03249012
(ClinicalTrials.gov)

September 1, 2017

9/8/2017

Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism

Comparing the Quality of Life Associated With Empiric Calcium Repletion and Parathormone (PTH) Based Calcium Repletion for Post Thyroidectomy Hypoparathyroidism

Hypoparathyroidism Postprocedural;Quality of Life

Other: Empiric use of Calcium Carbonate and Calcitriol;Other: PTH based Calcium Carbonate and Calcitriol repletion

CHU de Quebec-Universite Laval

NULL

Recruiting

18 Years

N/A

All

120

N/A

Canada

NCT04146259
(ClinicalTrials.gov)

January 1, 2017

29/10/2019

Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

Hypoparathyroidism Postprocedural

Drug: calcium carbonate and alphacalcidol

University of Athens

NULL

Completed

19 Years

N/A

Female

109

Greece

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT01815021
(ClinicalTrials.gov)

April 2013

7/3/2013

A Study Comparing Amorphous Calcium Carbonate (ACC) Versus Crystalline Calcium CCS) in Hypoparathyroidism Patients

A Randomized, Two Phase, Adaptive Then Crossover Open-label, Study Comparing Amorphous Calcium Carbonate (ACC) Supplement Versus Commercially Available Crystalline Calcium Supplements (CCS) in the Management of Primary Hypoparathyroidism.

Hypoparathyroidism

Dietary Supplement: amorphous calcium carbonate;Dietary Supplement: crystalline calcium supplements

Amorphical Ltd.

NULL

Completed

18 Years

80 Years

Both

Phase 1;Phase 2

Israel

JPRN-UMIN000002155

2009/09/01

06/07/2009

Effects of falecalcitoriol on post-operative hypoparathyroidism after thyroidectomy

Postoperative hypoparathyroidism

In the first day after operation, we start administration of falecalcitriol at a dosage of 0.6ug once a day, when below the lower limit of serum calcium. If serum calcium level do not reach normal range, we escalete to 0.9ug/day.Oral calcium lactate is administered 3g/day in all enrolled patients.The dose is reduced when serum calcium and intact PTH level are maintained within normal range. If subjective symptoms such as tetany are worsen up, we start administration of calcium via DIV.

kawasaki medicak school

NULL

Complete: follow-up complete

Not applicable

Male and Female

Phase 3

Japan

NCT00824226
(ClinicalTrials.gov)

January 2009

15/1/2009

Magnesium Treatment in Hypoparathyroidism

Effect of Magnesium Treatment on Plasma Calcium in Hypoparathyroid Patients

Hypoparathyroidism

Dietary Supplement: magnesium

University of Tartu

NULL

Completed

18 Years

N/A

Both

N/A

Estonia

JPRN-UMIN000000475

2006/07/01

01/09/2006

Therapeutic strategy of relative hypoparathyroidism in hemodialysis patients using sevelamer hydrochloride, with special reference to vitamin D administration

Relative hypoparathyoidism in maintenance hemodialysis patients

Replacement of calcium carbonate with sevelamer hydrochloride as phosphate binder

Hokusetsu ROD Study Group

NULL

Complete: follow-up complete

20years-old

Not applicable

Male and Female

Not applicable

Japan

NCT00581828
(ClinicalTrials.gov)

January 2005

19/12/2007

Does Treatment of Hypovitaminosis D Increase Calcium Absorption?

Osteoporosis;Osteopenia;Vitamin D Deficiency;Hypoparathyroidism;Hypercalciuria;Hypercalcemia

Drug: Vitamin D

University of Wisconsin, Madison

NULL

Completed

N/A

Female

Phase 4

United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT00004361
(ClinicalTrials.gov)

July 1995

18/10/1999

Study of the Relationship Between Calcium Levels and Intact Parathyroid Hormone (iPTH) in Adults With Repaired or Palliated Conotruncal Cardiac Defects

Hypoparathyroidism;Tetralogy of Fallot;Pulmonary Valve Stenosis;Conotruncal Cardiac Defects;Heart Defects, Congenital;Pulmonary Atresia

Drug: calcium gluconate;Drug: sodium citrate

National Center for Research Resources (NCRR)

Ann & Robert H Lurie Children's Hospital of Chicago

Completed

18 Years

N/A

Both

150

N/A

NULL

NCT00001304
(ClinicalTrials.gov)

October 1991

3/11/1999

Treatment of Hypoparathyroidism With Synthetic Human Parathyroid Hormone 1-34

Hypoparathyroidism

Drug: Synthetic Human Parathyroid Hormone 1-34;Drug: Calcitriol & Calcium

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NULL

Completed

17 Years

69 Years

All

Phase 2

United States