DDrare: Database of Drug Development for Rare Diseases

25. 進行性多巣性白質脳症
［臨床試験数：23，薬物数：33（DrugBank：20），標的遺伝子数：7，標的パスウェイ数：36］

Searched query = "Progressive multifocal leukoencephalopathy", "PML", "Leukoencephalopathy, progressive multifocal"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 111JC101; CYT107; Cidofovir; Collection of blood and urine; Cytarabine; Diagnostic Test: Brain MRI; Didanosine; Emtricitabine; Enfuvirtide; Filgrastim; Interferon alfa; Interferon alfa-2b; Interleukin-7; Lariam; MEFLOQUINE; METHYLPREDNISOLONE; Mefloquine; Methylprednisolone; Neurological evaluation; PREDNISOLONE; Pembrolizumab; Prednisolone; Probenecid; PyVST; Recombinant human interleukin-7; Spinal tap; Tenofovir; Tenofovir-Emtricitabine; Teriflunomide; Topotecan; Tysabri; Zalcitabine; Zidovudine

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00120367 (ClinicalTrials.gov)	April 2005	11/7/2005	Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)	Early Intensification of Combination Antiretroviral Therapy Including FUZEON® in the Treatment of Progressive Multifocal Leucoencephalopathy During HIV-1 Infection ANRS 125 Trial	Leukoencephalopathy, Progressive Multifocal;HIV Infections	Drug: Enfuvirtide;Drug: Tenofovir -Emtricitabine	French National Agency for Research on AIDS and Viral Hepatitis	Hoffmann-La Roche;Gilead Sciences	Completed	18 Years	N/A	Both	30	Phase 2	France

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT00120367
(ClinicalTrials.gov)

April 2005

11/7/2005

Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy (ANRS125)

Early Intensification of Combination Antiretroviral Therapy Including FUZEON® in the Treatment of Progressive Multifocal Leucoencephalopathy During HIV-1 Infection ANRS 125 Trial

Leukoencephalopathy, Progressive Multifocal;HIV Infections

Drug: Enfuvirtide;Drug: Tenofovir -Emtricitabine

French National Agency for Research on AIDS and Viral Hepatitis

Hoffmann-La Roche;Gilead Sciences

Completed

18 Years

N/A

Both

Phase 2

France