DDrare: Database of Drug Development for Rare Diseases

37. 膿疱性乾癬（汎発型）
［臨床試験数：58，薬物数：50（DrugBank：18），標的遺伝子数：17，標的パスウェイ数：96］

Searched query = "Generalised pustular psoriasis", "Pustular psoriasis", "Herpetic impetigo", "Generalization of acrodermatitis continua", "Generalization of dermatitis continua of the extremities"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = AIN457; AIN457, 150mg; ANAKINRA; ANB019; Acitretin; Adalimumab; Alefacept; Alvarez 2; Anakinra; Anti-IL-36R monoclonal antibody; BI 655130; BI655130; Brodalumab; Brodalumab 210mg SC; CNTO1959; Calcitriol; Certolizumab Pegol; Certolizumab pegol; Efalizumab; GUSELKUMAB; Guselkumab; Guselkumab 100 mg; Infliximab; Infliximab [infliximab biosimilar 3]; Ixekizumab; KHK4827; KHK4827 140mg SC; KHK4827 210mg SC; LY3074828; MONOCLONAL ANTIBODY ANTI-IGG1; Mirikizumab; Null; P32; P32/98; P32/98 3%; Placebo; Raptiva; Risankizumab; SECUKINUMAB; Secukinumab; Secukinumab 150 mg/1 mL Solution for injection; Secukinumab 150mg; Secukinumab 300mg; Silikis 3µg/g Salbe; Spesolimab; TA-650; TG; TREMFYA®; Tremfya; Ustekinumab

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000037099	2020-10-01	2020-08-26	The efficacy and safety of amino acids replacement based on metabolomics in generalized pustular psoriasis: a prospective, randomized, double-blind, controlled study	The efficacy and safety of amino acids replacement based on metabolomics in generalized pustular psoriasis: a prospective, randomized, double-blind, controlled study	Generalized pustular psoriasis	experimental group:amino acid infusion plus oral acitretin;control group:oral acitretin;	Shanghai Dermatology Hospital	NULL	Recruiting			Both	experimental group:20;control group:20;		China
2	ChiCTR-TRC-12003542	2011-08-01	2012-12-18	A Multi-center, randomized, double-blinded, double-dummy, parallel-controlled clinical trial to determine the efficacy and safety of Tripterygium Glycosides and Acitretin in patients with generalized pustular psoriasis	Guideline-oriented Research in the Management of Some Common and Severe Skin Diseases	Generalized pustular psoriasis	TG treatment group:Take TG tablet 2 slices every time, thrice a day, the placebo of Acitretin Capsules 2 pills every time, twice a day;Acitretin treatment group:Take the placebo of TG tablet 2 slices every time, thrice a day, Acitretin Capsules 2 pills every time, twice a day;	Institute of dermatology, Chinese Academy of Medical Sciences	NULL	Completed	16	75	Both	TG treatment group:180;Acitretin treatment group:180;		China

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

ChiCTR2000037099

2020-10-01

2020-08-26

The efficacy and safety of amino acids replacement based on metabolomics in generalized pustular psoriasis: a prospective, randomized, double-blind, controlled study

Generalized pustular psoriasis

experimental group:amino acid infusion plus oral acitretin;control group:oral acitretin;

Shanghai Dermatology Hospital

NULL

Recruiting

Both

experimental group:20;control group:20;

China

ChiCTR-TRC-12003542

2011-08-01

2012-12-18

A Multi-center, randomized, double-blinded, double-dummy, parallel-controlled clinical trial to determine the efficacy and safety of Tripterygium Glycosides and Acitretin in patients with generalized pustular psoriasis

Guideline-oriented Research in the Management of Some Common and Severe Skin Diseases

Generalized pustular psoriasis

TG treatment group:Take TG tablet 2 slices every time, thrice a day, the placebo of Acitretin Capsules 2 pills every time, twice a day;Acitretin treatment group:Take the placebo of TG tablet 2 slices every time, thrice a day, Acitretin Capsules 2 pills every time, twice a day;

Institute of dermatology, Chinese Academy of Medical Sciences

NULL

Completed

Both

TG treatment group:180;Acitretin treatment group:180;

China