DDrare: Database of Drug Development for Rare Diseases

70. 広範脊柱管狭窄症
［臨床試験数：91，薬物数：195（DrugBank：54），標的遺伝子数：60，標的パスウェイ数：85］

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 0.5% marcaine; 0.9% Saline; 0002-8971; 1mg/kg/hr TXA intravenous infusion till the last suture; AK1320 MS; Acetaminophen; Acetate; Adjunctive analgesics; Adjunctive anti-depressants; AlloGen-LI; Alprostadil; Amino acids; Aminocaproic acid; Amniotic Fluid Allograft; Apple; Bilateral transforaminal epidural steroid injections; Bone Marrow Concentrate; Botulinum toxin type A; Botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle; Bupivacaine; Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml; Buprenorphine; CO; Caudal Epidural Injection with Celestone; Caudal Epidural Injection with DepoMedrol; Caudal Epidural Injection with generic Celestone; Caudal epidural injection; Celebrex 200Mg Capsule; Celecoxib; Cilostazol; Combination Product: Goldic serum; Control group; Creatinine; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE; Darvocet; Decadron Phosphate, Injectable; Deksmedetomidiini; Demineralized Bone Matrix; DepoMedrol; Depomedrol; Device: Apple Watch and App; Device: Bioactive Glass-Ceramic Spacer; Device: Cervical Orthosis (CO); Device: Interbody cage (PEEK); Device: Interbody cage (titanium); Device: MILD® (Minimally Invasive Lumbar Decompression); Device: MRI; Device: MasterGraft Granules; Device: No Orthosis; Device: Philips Intelivue MP70 monitor; Device: Pleth Variability Index (PVI); Device: Therm-AppTM TH, thermographic camera; Device: Titanium cage; Dexamethasone; Dexamethasone sodium phosphate; Dexdor; Dexmedetomidine; Dexmedetomidine group; Dexmedetomidine with ropivacaine; Dextrose; Diphenhydramine; EACA; ESKETAMINE HYDROCHLORIDE; Epidural Steroid Injection; Epidural injection; Epidural local anesthetic injection; Epidural steroid injection; Epsilon-Aminocaproic Acid (EACA); Erector spinae plane block (Group E); Erythropoietin; Esketamine; Fentanyl; Forsteo; Forteo; Gabapentin; Heparin; Herbal medicine; Hyaluronic Acid; Hyaluronic acid; Hydromorphone; I-FACTOR; KETAMINE; Kenalog Injectable Product; Ketamine; Ketanest; Ketanest-S; Ketorolac; Limaprost; Liposomal bupivacaine; Lumbar Interbody Fusion with Autograft; Lumbar Interbody Fusion with NeoFuse; MONITOR; Magnesium; Magnesium with ropivacaine; Midazolam; Mirogabalin; Misoprostol; Modal; Modified-thoracolumbar interfascial plane block; Morphine; Morphine PCA; Multi-modal pain management [Acetaminophen + Gabapentin]; Multi-modal pain management [Fentanyl]; Multi-modal pain management [Intravenous Ketamine]; Multi-modal pain management [Valium + Gabapentin]; NS-304; NS-304 Placebo; NSAIDs; NeoFuse; Nicardipine; Normal saline; NuCel; OXYCODONE; OXYCODONE HYDROCHLORIDE; Oksikodoni; Opana; Other: Control; Other: Conventional PCA mode; Other: Epiduroscopy; Other: Group Exercise: community setting; Other: Individualized exercises: clinical setting; Other: Joint Mobilizations (spine, sacroiliac, hip); Other: Optimizing basal infusion (B.I); Other: Other intervention(s); Other: no intervention; Other: physical therapy; Oxanest; Oxycodone; Oxycodone Orion; Oxygen; PCA; PLF with NeoFuse; Parathyroid hormone; Phosphate; Polydeoxyribonucleotides; Predinose oral; Pregabalin; Pregabalin 75mg; Procedure: Acupuncture; Procedure: Allograft; Procedure: Bee venom pharmacopuncture; Procedure: Chuna manipulation; Procedure: Chuna manual medicine; Procedure: Cupping; Procedure: Electroacupuncture; Procedure: Epidural Steroid Injection; Procedure: Epidural local anesthetic injection; Procedure: Epidural steroid with local anesthetic injection; Procedure: Lumbar epidural injection; Procedure: MILD Procedure; Procedure: Manual therapy; Procedure: Other intervention(s); Procedure: PLF with autograft; Procedure: Percutaneous Lumbar Decompression; Procedure: Pharmacopuncture; Procedure: epidural steroid (dexamethasone) injection; Procedure: lumbar interlaminar epidural steroid injection; Procedure: posterolateral spinal fusion with instrumentation; Prolotherapy solution of 20% dextrose; Remifentanil; RhPTH; RhPTH (1-34); Ropivacaine; Ropivacaine plus normal saline; S-ketamine; S-ketamine & midazolam; Selexipag; Standard analgesia use [Fentanyl]; Standard analgesia use [Hydromorphone]; Standard analgesia use [Oxygen]; Standard analgesia use [Volatile Anesthesia]; Steroid injections; Sufentanil; Sugar Pill; Teicoplanin; Teriparatide; Teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34); Titanium; Tramadol; Tramadol with ropivacaine; Tranexamic Acid; Tranexamic Acid 100 MG/ML; Tranexamic acid; Transdermal fentanyl matrix, gabapentin; Transforaminal Epidural Injection; Triamcinolone; Triamcinolone Acetonide and normal saline solution; Tylenol; Vancomycin; ViviGen Cellular Bone Matrix; With U-VANCO (vancomycin hydrochloride); Without U-VANCO (vancomycin hydrochloride); Wound topically irrigated with 500mg TXA; Xylocaine

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000028775	2020-02-01	2020-01-03	Safety and effectiveness of pregabalin in the management of postoperative pain in lumbar surgery	Safety and effectiveness of pregabalin in the management of postoperative pain in lumbar surgery	1. Lumbar disc herniation; 2. Lumbar spinal stenosis; 3. Lumbar spondylolisthesis	Pregabalin group: ?????????? ?????????? Postoperative analgesia with pregabalin;Celecoxib group: Postoperative analgesia with celecoxib;	The First Affiliated Hospital of Chongqing Medical University	NULL	Recruiting	18	80	Both	Pregabalin group:60;Celecoxib group:60;		China
2	NCT03584074 (ClinicalTrials.gov)	July 1, 2018	29/6/2018	Clinical Trial of Pregabalin and COX2 in Spinal Stenosis	Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial	Spinal Stenosis Lumbar	Drug: Pregabalin 75mg;Drug: Celebrex 200Mg Capsule	Seoul National University Bundang Hospital	NULL	Unknown status	40 Years	N/A	All	60	Phase 4	NULL
3	NCT01888536 (ClinicalTrials.gov)	February 2013	25/6/2013	A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	A Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	Neurologic Claudication in Patients With Lumbar Spinal Stenosis	Drug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost)	Yungjin Pharm. Co., Ltd.	NULL	Completed	20 Years	75 Years	Both	182	Phase 4	Korea, Republic of
4	JPRN-UMIN000007419	2012/04/01	01/04/2012	A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal Stenosis		Lumbar Spinal Stenosis	Celecoxib Pregabalin	Department of Orthopedic Surgery Kobe University Graduate School of Medicine	NULL	Pending	50years-old	90years-old	Male and Female	80	Not selected	Japan
5	NCT00908375 (ClinicalTrials.gov)	May 2009	21/5/2009	Efficacy of Pregabalin in Patients With Radicular Pain	Efficacy of Pregabalin in Patients With Radicular Pain	Neuropathy; Radicular, Lumbar, Lumbosacral;Failed Back Surgery Syndrome;Spinal Stenosis;Herniated Disc	Drug: Pregabalin;Drug: Sugar Pill	Northwestern University	NULL	Completed	18 Years	64 Years	All	39	Phase 4	United States
No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
6	NCT00638443 (ClinicalTrials.gov)	March 2008	12/3/2008	Lumbar Stenosis Outcomes Research (LUSTOR)	Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain	Lumbar Spinal Stenosis	Drug: Pregabalin;Drug: Diphenhydramine	University of Rochester	Pfizer	Completed	50 Years	N/A	All	29	Phase 4	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

ChiCTR2000028775

2020-02-01

2020-01-03

Safety and effectiveness of pregabalin in the management of postoperative pain in lumbar surgery

1. Lumbar disc herniation; 2. Lumbar spinal stenosis; 3. Lumbar spondylolisthesis

Pregabalin group: ?????????? ?????????? Postoperative analgesia with pregabalin;Celecoxib group: Postoperative analgesia with celecoxib;

The First Affiliated Hospital of Chongqing Medical University

NULL

Recruiting

Both

Pregabalin group:60;Celecoxib group:60;

China

NCT03584074
(ClinicalTrials.gov)

July 1, 2018

29/6/2018

Clinical Trial of Pregabalin and COX2 in Spinal Stenosis

Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial

Spinal Stenosis Lumbar

Drug: Pregabalin 75mg;Drug: Celebrex 200Mg Capsule

Seoul National University Bundang Hospital

NULL

Unknown status

40 Years

N/A

All

Phase 4

NULL

NCT01888536
(ClinicalTrials.gov)

February 2013

25/6/2013

A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis

A Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis

Neurologic Claudication in Patients With Lumbar Spinal Stenosis

Drug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost)

Yungjin Pharm. Co., Ltd.

NULL

Completed

20 Years

75 Years

Both

182

Phase 4

Korea, Republic of

JPRN-UMIN000007419

2012/04/01

01/04/2012

A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal Stenosis

Lumbar Spinal Stenosis

Celecoxib

Pregabalin

Department of Orthopedic Surgery Kobe University Graduate School of Medicine

NULL

Pending

50years-old

90years-old

Male and Female

Not selected

Japan

NCT00908375
(ClinicalTrials.gov)

May 2009

21/5/2009

Efficacy of Pregabalin in Patients With Radicular Pain

Neuropathy; Radicular, Lumbar, Lumbosacral;Failed Back Surgery Syndrome;Spinal Stenosis;Herniated Disc

Drug: Pregabalin;Drug: Sugar Pill

Northwestern University

NULL

Completed

18 Years

64 Years

All

Phase 4

United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT00638443
(ClinicalTrials.gov)

March 2008

12/3/2008

Lumbar Stenosis Outcomes Research (LUSTOR)

Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain

Lumbar Spinal Stenosis

Drug: Pregabalin;Drug: Diphenhydramine

University of Rochester

Pfizer

Completed

50 Years

N/A

All

Phase 4

United States