2. Amyotrophic lateral sclerosis
508 clinical trials,   530 drugs   (DrugBank: 146 drugs),   170 drug target genes,   221 drug target pathways

Searched query = "Amyotrophic lateral sclerosis", "ALS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
30 trials found
No.TrialIDDate_
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1NCT04651855
(ClinicalTrials.gov)
December 2, 202030/9/2020The Evaluation of the Effect of Mesenchymal Stem Cells on the Immune System of Patients With ALSThe Evaluation of the Effect of Wharton's Jelly Mesenchymal Stem Cells (WJMSCs) on the Immune System of Patients With Amyotrophic Lateral Sclerosis (ALS)Amyotrophic Lateral SclerosisDrug: Mesenchymal stem cells isolated from Wharton's jellyPolski Bank Komorek Macierzystych JSC (PBKM)The National Centre for Research and DevelopmentRecruiting18 YearsN/AAll20Phase 1;Phase 2Poland
2NCT04514952
(ClinicalTrials.gov)
September 1, 202012/8/2020Individual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral SclerosisIndividual Patient Expanded Access IND of Autologous HBadMSCs for the Treatment of Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisDrug: HB-adMSCsHope BiosciencesHope Biosciences Stem Cell Research FoundationNo longer availableN/AN/AAllUnited States
3EUCTR2019-002302-46-ES
(EUCTR)
23/10/201909/08/2019Phase II clinical trial of intramuscular infusion of autologous bone marrow stem cells in patients with amyotrophic lateral sclerosisPhase II clinical trial of intramuscular infusion of autologous bone marrow stem cells in patients with amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]Fundación para la Formación e Investigación Sanitarias de la Región de MurciaNULLAuthorised-recruitment may be ongoing or finished Female: yes
Male: yes
100Phase 2Spain
4NCT03482050
(ClinicalTrials.gov)
April 12, 201814/3/2018A Study to Evaluate Transplantation of Astrocytes Derived From Human Embryonic Stem Cells, in Patients With Amyotrophic Lateral Sclerosis (ALS)A Phase I/IIa, Open Label, Dose-escalating Clinical Study to Evaluate the Safety, Tolerability and Theraputic Effects of Transplantation of Astrocytes Derived From Human Embryonic Stem Cells (hESC), in Patients With Amyotrophic Lateral Sclerosis (ALS)ALS (Amyotrophic Lateral Sclerosis)Biological: AstroRxKadimastemNULLRecruiting18 Years70 YearsAll21Phase 1;Phase 2Israel
5NCT03280056
(ClinicalTrials.gov)
August 28, 201729/8/2017Safety and Efficacy of Repeated Administrations of NurOwn® in ALS PatientsA Phase 3, Randomized Double-Blind, Placebo-Controlled Multicenter Study to Evaluate Efficacy and Safety of Repeated Administration of NurOwn® (Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors) in Participants With ALSAmyotrophic Lateral Sclerosis (ALS)Biological: NurOwn® (MSC-NTF cells);Other: PlaceboBrainstorm-Cell TherapeuticsCalifornia Institute for Regenerative Medicine (CIRM)Active, not recruiting18 Years60 YearsAll261Phase 3United States
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
6NCT02943850
(ClinicalTrials.gov)
April 1, 201720/10/2016CNS10-NPC-GDNF for the Treatment of ALSHuman Neural Progenitor Cells Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisBiological: Stem cell (HPC) implantation;Device: Stereotactic surgical deviceCedars-Sinai Medical CenterCalifornia Institute for Regenerative Medicine (CIRM)Completed18 YearsN/AAll18Phase 1United States
7NCT03214146
(ClinicalTrials.gov)
February 1, 20179/7/2017Safety/Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in ALSAn Open-label, Phase 1 Trial for Safety and Efficacy Study of 2nd Cycle Treatment After 6 Months of 1st Cycle HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell(HYNR-CS-Allo Inj) Treatment in Amyotrophic Lateral Sclerosis(ALS)Amyotrophic Lateral SclerosisBiological: HYNRCS-Allo injHanyang University Seoul HospitalCorestem, Inc.Active, not recruiting25 Years80 YearsAll6Phase 1Korea, Republic of
8NCT03067857
(ClinicalTrials.gov)
September 201625/2/2017Autologous Bone Marrow-Derived Stem Cell Therapy for Motor Neuron DiseaseAutologous Purified Bone-Marrow-Derived Stem Cell Therapy for Motor Neuron DiseaseMotor Neuron Disease;Amyotrophic Lateral Sclerosis;Primary Lateral Sclerosis;Progressive Muscular Atrophy;Progressive Bulbar PalsiesBiological: Stem CellsStem Cells ArabiaNULLUnknown status24 Years70 YearsAll40Phase 1;Phase 2NULL
9NCT02881476
(ClinicalTrials.gov)
November 201522/4/2016Therapeutic Treatment of Amyotrophic Lateral SclerosisApplication of Wharton's Jelly-derived Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisOther: Biological: Cell-based therapyUniversity of Warmia and MazuryNULLEnrolling by invitation18 Years65 YearsBoth30Phase 1NULL
10NCT02881489
(ClinicalTrials.gov)
November 201522/4/2016Autologous Bone Marrow Mesenchymal Stem Cells in the Treatment of Patients With Amyotrophic Lateral SclerosisEvaluation of Mesenchymal Stem Cell Culturing Protocols in the Treatment of Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisOther: Biological: Cell-based therapyUniversity of Warmia and MazuryNULLEnrolling by invitation18 Years65 YearsBoth30Phase 1NULL
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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PhaseCountries
11NCT02116634
(ClinicalTrials.gov)
May 20156/4/2014Mesenchymal Stem Cell Injection in Amyotrophic Lateral SclerosisPhase 1, 2 Study of Mesenchymal Stem Cells Injection in ALS (Amyotrophic Lateral Sclerosis) PatientsAmyotrophic Lateral SclerosisBiological: mesenchymal stem cellAlzahra Hospital, IranNULLWithdrawn18 Years60 YearsBoth0Phase 1;Phase 2Iran, Islamic Republic of
12NCT02987413
(ClinicalTrials.gov)
April 28, 20151/7/2016Escalated Application of Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis PatientsSafety and Efficacy of Mesenchymal Stem Cells Escalated Application in Amyotrophic Lateral Sclerosis Patients: Study Design of a Phase I TrialMotor Neuron DiseaseBiological: Autologous Mesenchymal stem cells (MSCs)Hospital e Maternidade Dr. Christóvão da GamaIEP São Lucas - Instituto de Ensino e Pesquisa;Clinica Jordy Sinapse;TECHLIFE - Centro de Tecnologia CelularCompleted18 YearsN/AAll3Phase 1Brazil
13NCT02286011
(ClinicalTrials.gov)
November 201424/10/2014Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral SclerosisPhase I Clinical Trial on Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral Sclerosis.ALS (Amyotrophic Lateral Sclerosis)Biological: MNC (Mononuclear cells);Other: SalineRed de Terapia CelularSpanish National Health System;Hospital Universitario Virgen de la Arrixaca;Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia;Public Health Service, Murcia;Instituto Murciano de Investigación Biosanitaria Virgen de la ArrixacaActive, not recruiting18 Years70 YearsAll20Phase 1Spain
14NCT02492516
(ClinicalTrials.gov)
September 201424/6/2015Intravenous Injection of Adipose Derived Mesenchymal Stem Cell for ALSEvaluation the Safety of Intravenous Injection of Adipose Derived Mesenchymal Stem Cell in Patients With ALSAmyotrophic Lateral SclerosisBiological: mesenchymal stem cellsRoyan InstituteNULLCompleted18 Years55 YearsAll19Phase 1Iran, Islamic Republic of
15EUCTR2011-004801-25-ES
(EUCTR)
16/07/201411/01/2013CLINICAL TRIAL ON THE USE OF BONE MARROW OWN PATIENT'S WITH AMYOTROPHIC LATERAL SCLEROSISA PHASE I/II CLINICAL TRIAL OF THE BONE MARROW'S AUTOLOGOUS STEM CELLS IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS amyotrophic lateral sclerosis
MedDRA version: 15.1;Level: PT;Classification code 10002026;Term: Amyotrophic lateral sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Body processes [G] - Immune system processes [G12]
Product Name: células troncales hematopoyéticas autólogas adultas extraidas de médula ósea
INN or Proposed INN: autologous bone marrow mononucleated cells
Other descriptive name: autologous bone marrow mononucleated cells
Fundación Sanitaria para el Fomento de la Investigación Sanitaria y Biomédica de la Comunidad Valenciana (FISABIO)NULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Phase 1;Phase 2Spain
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
16NCT02290886
(ClinicalTrials.gov)
July 20149/10/2014A Multicenter Phase I/II Clinical Trial to Evaluate Safety of Mesenchymal Stem Cell in Patients With Amyotrophic Sclerosis LateralA Multicenter Phase I/II Clinical Trial, Randomized, Controlled With Placebo, Triple Blind to Evaluate Safety, and Indications of Efficiency of the Intravenous Administration of the Therapy With 3 Doses of MSC in Patients With ASL Moderated to SevereAmyotrophic Lateral SclerosisOther: Intravenous administration of placebo;Drug: Intravenous administration of 1 million of MSC;Drug: Intravenous administration of 2 million of MSC;Drug: Intravenous administration of 4 million of MSCAndalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y SaludIniciativa Andaluza en Terapias AvanzadasActive, not recruiting18 YearsN/AAll52Phase 1;Phase 2Spain
17NCT02017912
(ClinicalTrials.gov)
May 201417/12/2013Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study of Autologous MSC-NTF Cells in Patients With ALSA Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study to Evaluate Safety and Efficacy of Transplantation of Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors (MSC-NTF) in Patients With ALSAmyotrophic Lateral Sclerosis (ALS)Biological: Autologous MSC-NTF cells;Biological: PlaceboBrainstorm-Cell TherapeuticsNULLCompleted18 Years75 YearsAll48Phase 2United States
18NCT01759784
(ClinicalTrials.gov)
March 201429/12/2012Intraventricular Transplantation of Mesenchymal Stem Cell in Patients With ALSSafety of Intraventricular Injection of Bone Marrow Derived Mesenchymal Stem Cell in Patients With ALSAmyotrophic Lateral SclerosisBiological: Intraventricular injectionRoyan InstituteNULLWithdrawn18 Years70 YearsBoth0Phase 1Iran, Islamic Republic of
19NCT01771640
(ClinicalTrials.gov)
August 201316/1/2013Intrathecal Transplantation of Mesenchymal Stem Cell in Patients With ALSIntrathecal Transplantation of Autologous Bone Marrow Derived Mesenchymal Stem Cell in Patients With ALSAmyotrophic Lateral SclerosisBiological: intrathecal injectionRoyan InstituteNULLCompleted18 Years65 YearsAll8Phase 1Iran, Islamic Republic of
20EUCTR2011-006254-85-ES
(EUCTR)
08/02/201309/08/2012Clinical trial to value the safety and efficacy of administration of stem cells derived from own patient for the treatment of Amyotrophic Lateral Sclerosis (ALS).Placebo controlled, randomized and triple blind multicentric phase I/II clinical trial to evaluate the safety, feasibility and valoration of efficacy trends of intravenous administration of three doses of autologous adipose derived autologous mesenchymal stem cells (CeTMAd) in moderate/severe ALS patients. Amyotrophic lateral sclerosis (ALS)
MedDRA version: 14.1;Level: PT;Classification code 10002026;Term: Amyotrophic lateral sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Product Name: Células madre mesenquimales de tejido adiposo autólogo
INN or Proposed INN: NA
Other descriptive name: Células Mesenquimales de tejido adiposo
FUNDACIÓN PROGRESO Y SALUDNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Phase 1;Phase 2Spain
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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PhaseCountries
21NCT01759797
(ClinicalTrials.gov)
January 201331/12/2012Intravenous Transplantation of Mesenchymal Stem Cell in Patients With ALSSafety of Intravenous Transplantation of Bone Marrow Derived Mesenchymal Stem Cell in Patients With ALSAmyotrophic Lateral SclerosisBiological: intra venous injection of stem cellRoyan InstituteNULLCompleted18 Years65 YearsBoth6Phase 1Iran, Islamic Republic of
22NCT01933321
(ClinicalTrials.gov)
September 201228/9/2012Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)Amyotrophic Lateral SclerosisBiological: Intrathecal autologous stem cellHospital Universitario Dr. Jose E. GonzalezNULLCompleted18 YearsN/ABoth14Phase 2;Phase 3Mexico
23NCT01609283
(ClinicalTrials.gov)
May 201218/5/2012A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral SclerosisA Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisBiological: autologous mesenchymal stem cellsMayo ClinicNULLCompleted18 YearsN/AAll27Phase 1United States
24EUCTR2011-000362-35-CZ
(EUCTR)
29/03/201205/04/2011Safety and Efficacy of Stem Cell Therapy of Motor Neuron Disease.A Prospective, Non-randomized, Open Label Study to Assess the Safety and the Efficacy of Autologous Multipotent Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis. - AMSC in ALS Amyotrophic lateral sclerosis
MedDRA version: 17.0;Level: PT;Classification code 10002026;Term: Amyotrophic lateral sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Product Name: Suspension of human autologous MSC 3P in 1,5 ml
Product Code: AMSC
INN or Proposed INN: Human autologous mesenchymal stem cells
Bioinova, s.r.o.NULLNot RecruitingFemale: yes
Male: yes
30Phase 2Czech Republic
25NCT01640067
(ClinicalTrials.gov)
December 20119/7/2012Human Neural Stem Cell Transplantation in Amyotrophic Lateral Sclerosis (ALS)Intra-spinal Cord Delivery of Human Neural Stem Cells in ALS Patients: Proposal for a Phase I Study/ Trapianto Intramidollare di Cellule Staminali Neurali Umane Come Terapia Putativa Per la SLA: Proposta di un Trial Clinico di Fase IAmyotrophic Lateral SclerosisBiological: Human Neural Stem CellsAzienda Ospedaliera Santa Maria, Terni, ItalyAzienda Ospedaliero Universitaria Maggiore della Carita;Università di Padova ItalyCompleted20 Years75 YearsBoth18Phase 1Italy
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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Inclusion_
agemin
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PhaseCountries
26NCT01363401
(ClinicalTrials.gov)
February 201130/5/2011Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral SclerosisAn Open-label, Phase I/II Trial for Safety and Efficacy Study of Autologous Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis;ALSBiological: HYNR-CS inj;Other: Control groupCorestem, Inc.NULLCompleted25 Years75 YearsAll72Phase 1;Phase 2Korea, Republic of
27NCT01142856
(ClinicalTrials.gov)
June 201010/6/2010Mesenchymal Stem Cells for Treatment of Amyotrophic Lateral Sclerosis (ALS)A Single Patient Treatment Protocol for Autologous Mesenchymal Stem Cell Intraspinal Therapy in Amyotrophic Lateral Sclerosis (ALS)Amyotrophic Lateral SclerosisBiological: autologous mesenchymal stem cellsMayo ClinicNULLCompleted18 YearsN/ABoth1Phase 1United States
28NCT01082653
(ClinicalTrials.gov)
March 20101/3/2010Safety/Efficacy Study for the Treatment of Amyotrophic Lateral SclerosisPhase I, Single Center, Prospective, Non-randomized, Open Label, Safety/Efficacy Study of the Infusion of Autologous Bone Marrow-derived Stem Cells, in Patients With Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisBiological: autologous bone marrow-derived stem cellsTCA Cellular TherapyNULLSuspended18 Years80 YearsBoth6Phase 1United States
29NCT02242071
(ClinicalTrials.gov)
December 200812/9/2014Cell Therapy for Motor Neuron Disease/Amyotrophic Lateral SclerosisThe Effect of Autologous Bone Marrow Mononuclear Cell Transplantation on Motor Neuron Disease/Amyotrophic Lateral SclerosisAmyotrophic Lateral SclerosisBiological: Stem CellNeurogen Brain and Spine InstituteNULLWithdrawn18 Years80 YearsAll0Phase 1India
30NCT01984814
(ClinicalTrials.gov)
December 20088/11/2013Stem Cell Therapy for Amyotrophic Lateral SclerosisThe Effect of Autologous Bone Marrow Mononuclear Cell Transplantation on the Survival Duration in Amyotrophic Lateral Sclerosis - A Retrospective Control StudyAmyotrophic Lateral SclerosisBiological: Stem cellNeurogen Brain and Spine InstituteNULLWithdrawn26 Years76 YearsAll0Phase 2India