DDrare: Database of Drug Development for Rare Diseases

Searched query = "Fragile X syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 11C-flumazenil; 18F-FTC-146; ACIDUM ASCORBICUM D6; AF056; AFQ056; AZD7325; AZD7325 (High-Dose); AZD7325 (Low-Dose); Acamprosate; Acetate; Acidum ascorbicum; Alpha-tocopherol; Ampalex; Arbaclofen; Aripiprazole; Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E); Ascorbic acid; BPN14770; CBD; CCD 1042, MD 9150000, Mepalon 1042, SPT316; CX516; CX516 (Ampalex®); Donepezil; EGCG; EGCG FontUp; Flumazenil; Fluoxetin; GANAXOLONE; Gaboxadol; Ganaxolone; Lovastatin; Lovastatin, then Minocycline/Lovastatin; MG01CI extended-release tablet; MGlu5 antagonist; Mavoglurant; Metformin; Methylphenidate; Methylphenidate, fluoxetin, risperidone; Minocycline; Minocycline hydrochloride; Minocycline, then Minocycline/Lovastatin; NNZ-2566; NPL-2009; OV101; OV101 (gaboxadol); Other: Biological samples; Other: Cognitive training; Other: Language Intervention; Other: MRI; Oxytocin; Oxytocin 24IU; Oxytocin 48IU; RO4917523; RO4917523 0.5 mg; RO4917523 1.5 mg; Riluzole; Risperidone; Ro 491-7523/F18; Ro 491-7523/F19; STX107; STX209; Sertraline; Sugar pill; TOCOPHERYL ACETATE; Tocopherol; Tocopheryl acetate; Vitamin C; Vitamin C 10mg/Kg Vitamin E 10 mg/Kg; Vitamin E; ZYN002 - CBD Transdermal Gel; [18F]FPEB; [18F]FPEB PET imaging; [18F]flumazenil

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02998151 (ClinicalTrials.gov)	January 2016	1/12/2016	Single-Dose Acamprosate, Lovastatin, Minocycline and Placebo in Fragile X Syndrome	Evaluating the Neurophysiologic and Clinical Effects of Single-Dose Acamprosate, Lovastatin, Minocycline and Placebo in Fragile X Syndrome	Fragile X Syndrome	Drug: Acamprosate;Drug: Lovastatin;Drug: Minocycline;Drug: Placebo	Children's Hospital Medical Center, Cincinnati	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Enrolling by invitation	15 Years	55 Years	All	36	Phase 2	United States
2	NCT01911455 (ClinicalTrials.gov)	June 2013	26/7/2013	Study of Acamprosate in Fragile x Syndrome	Double-Blind, Placebo-Controlled Proof of Concept Study in Youth With Fragile X Syndrome	Fragile X Syndrome	Drug: acamprosate;Drug: Placebo	Children's Hospital Medical Center, Cincinnati	Rush University Medical Center	Active, not recruiting	5 Years	23 Years	All	48	Phase 2;Phase 3	United States
3	NCT01300923 (ClinicalTrials.gov)	August 2010	25/8/2010	Acamprosate in Youth With Fragile X Syndrome	Pilot Study of Acamprosate in Youth With Fragile X Syndrome	Fragile X Syndrome;Autism Spectrum Disorders	Drug: Acamprosate	Indiana University	NULL	Completed	5 Years	17 Years	All	14	Phase 2	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT02998151
(ClinicalTrials.gov)

January 2016

1/12/2016

Single-Dose Acamprosate, Lovastatin, Minocycline and Placebo in Fragile X Syndrome

Evaluating the Neurophysiologic and Clinical Effects of Single-Dose Acamprosate, Lovastatin, Minocycline and Placebo in Fragile X Syndrome

Fragile X Syndrome

Drug: Acamprosate;Drug: Lovastatin;Drug: Minocycline;Drug: Placebo

Children's Hospital Medical Center, Cincinnati

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Enrolling by invitation

15 Years

55 Years

All

Phase 2

United States

NCT01911455
(ClinicalTrials.gov)

June 2013

26/7/2013

Study of Acamprosate in Fragile x Syndrome

Double-Blind, Placebo-Controlled Proof of Concept Study in Youth With Fragile X Syndrome

Fragile X Syndrome

Drug: acamprosate;Drug: Placebo

Children's Hospital Medical Center, Cincinnati

Rush University Medical Center

Active, not recruiting

5 Years

23 Years

All

Phase 2;Phase 3

United States

NCT01300923
(ClinicalTrials.gov)

August 2010

25/8/2010

Acamprosate in Youth With Fragile X Syndrome

Pilot Study of Acamprosate in Youth With Fragile X Syndrome

Fragile X Syndrome;Autism Spectrum Disorders

Drug: Acamprosate

Indiana University

NULL

Completed

5 Years

17 Years

All

Phase 2

United States