222. Primary nephrotic syndrome
234 clinical trials,   241 drugs   (DrugBank: 78 drugs),   59 drug target genes,   185 drug target pathways

Searched query = "Primary nephrotic syndrome", "Minimal change nephrotic syndrome", "MCNS", "Membranous nephropathy", "Focal segmental glomerulosclerosis", "FSGS", "Membranoproliferative glomerulonephritis", "MPGN"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
2 trials found
No.TrialIDDate_
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PhaseCountries
1NCT04424862
(ClinicalTrials.gov)
June 20207/6/2020Multitarget Therapy for Idiopathic Membranous NephropathyMultitarget Therapy for Idiopathic Membranous NephropathyEfficacyDrug: Prednisone, ciclosporin and mycophenolate mofetil;Drug: Ponticelli RegimenBeijing Friendship HospitalNULLNot yet recruiting18 Years70 YearsAll78Phase 4China
2JPRN-UMIN000001099
2007/10/0131/03/2008Optimal use of ciclosporin in idiopathic membranous nephropathy associated with nephrotic syndrome idiopathic membranous nephropathy associated with nephrotic syndromeSteroid group: Immunosuppressive therapy is started by predonisolone 0.8mg/kg/day (max 60mg/day). The dose is decreased by 5mg/day in 2 to 4 weeks after remission. The cases who do not reach remission for 4 weeks, predonisolone is decreased to 0.6mg/kg/day, and ciclosporin (2mg/kg/day) is started once a day. Serum concentration of ciclosporin is measured 2hr after administration, and the dose is adjusted. (The target serum concentration is 800-1000ng/mL.)
Steroid + ciclosporin group: Immunosupressive therapy is started by predonisolone 0.6mg/kg/day and ciclosporin 2mg/kg/day (once a day). Serum concentration of ciclosporin is measured 2hr after administration, and the dose is adjusted. (The target serum concentration is 800-1000ng/mL.) The dose of predonisolone is decreased by 5mg/day in 2 to 4 weeks after remission. Ciclosporin is continued after remission. (The target C2 is 600-800 ng/mL.) The cases who do not reach remission after 4 weeks, predonisolone is decreased by 5mg/4-8week, and ciclosporin is continued for 6 months. The target C2 is 800-1000ng/mL. At 6 months after, the therapy of non-respnder is not restricted.
Division of Kidney and Dialysis, Department of Internal Medicine,Hyogo College of MedicineNULL16years-oldNot applicableMale and Female50Phase 4Japan