25. Progressive multifocal leukoencephalopathy
23 clinical trials, 33 drugs (DrugBank: 20 drugs), 7 drug target genes, 36 drug target pathways
Searched query = "Progressive multifocal leukoencephalopathy", "PML", "Leukoencephalopathy, progressive multifocal"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01970410 (ClinicalTrials.gov) | October 2013 | 22/10/2013 | Sub-Study: Analysis of JCV Antibody Index in MS Patients Treated With Teriflunomide - SWITCH-JCV | Switching Relapsing Multiple Sclerosis Patients Treated With Natalizumab at Risk for Progressive Multifocal Leukoencephalopathy to Teriflunomide: Is This Safe and Effective? (Sub-study: SWITCH-JCV) | Multiple Sclerosis | Drug: teriflunomide | Providence Health & Services | Multiple Sclerosis Center of Northeastern New York | Recruiting | 21 Years | 60 Years | All | 70 | Phase 4 | United States |
| 2 | EUCTR2010-020369-26-DE (EUCTR) | 29/11/2010 | 18/08/2010 | High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab | High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab | Immune Reconstitution Inflammatory Syndrome MedDRA version: 12.1;Level: PT;Classification code 10054014;Term: Immune reconstitution syndrome | Product Name: methylprednisolone INN or Proposed INN: METHYLPREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE | Biogen Idec | NULL | Not Recruiting | Female: yes Male: yes | 20 | Germany | |||
| 3 | NCT01211665 (ClinicalTrials.gov) | September 2010 | 29/7/2010 | Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) | High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab | Immune Reconstitution Inflammatory Syndrome;Leukoencephalopathy, Progressive Multifocal | Drug: Methylprednisolone;Drug: Prednisolone | Biogen | Elan Pharmaceuticals | Terminated | 18 Years | N/A | All | 3 | Phase 4 | United States;Germany |