DDrare: Database of Drug Development for Rare Diseases

Searched query = "Osteogenesis Imperfecta"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = ACLASTA; AMG 162; AMG 785; ANTI-SCLEROSTIN MONOCLONAL ANTIBODY; Aclasta; Actonel 5mg Film Coated Tablets; Actonel Once a Week 35 mg film-coated tablets; Actonel/Optinate 5mg film-coated tablets; Alendronate; Alendronic acid; Anti-sclerostin monoclonal antibody; BOOST cells; BPS804; Bisphosphonates; Blood sample; Bone marrow transplant; Bonefos; Busulfan; Calcichew tablets; Calcium; Celulas madre mesenquimales troncales adultas alogenicas de médula ósea no expandida; Cyclophosphamide; Cyclosporin; Células mesenquimales troncales adultas alogénicas de médula ósea no expandidas; Células mesenquimales troncales adultas alogénicas de médula ósea no expandidas(ref cruzada PEI nº 12-088); DENOSUMAB; Denosumab; Denosumab - - Immunoglobulin G2 Human Monoclonal Antibody to RANK Ligand; Denosumab - Immunoglobulin G2 Human Monoclonal Antibody to RANK Ligand; Denusomab; Disodium Pamidronate 15mg (15mg strength); Expanded human first trimester fetal liver-derived mesenchymal stem cells; Forsteo; Fresolimumab; GENOTROPIN*1TBF 5,3MG (16UI); H05AA02; High-dose vitamin D (2000 IU per day); Humatrope; Ibandronic acid; Ibandronic acid solution; Mesenchymal Stem Cells; Mesenchymal Stromal Cells; NERIXIA*INFUS IV CONC 2F 100MG; Optinate 5 mg filmcoated tablets; Other: Bone Marrow Cell Transplantation; Other: No active treatment; Other: saline; Pamidronate; Pamidronate (Aredia); Pamidronate sodium; Procedure: Mesenchymal Stem Cell Transplantation; Prolia; REF CRUZADA PEI Nº 12-088; RITUXIMAB; ROMOSOZUMAB; Radiation: Irradiation, Total Body; Risedronate; Risedronate Oral Tablet; Risedronate Sodium; Risedronate sodium; Risedronate sodium (Actonel); Risedronate sodium 2.5mg; Risedronate sodium 5mg; Risedronato sódico 2.5mg; Risedronato sódico 5mg; Risedronic acid; Rituximab; Romosozumab; Setrusumab; Somatropin; Standard-dose vitamin D (400IU per day); Teriparatide; Teriparatide (FORTEO); Teriparatide Pen Injector; VARI; Vitamin D; XGEVA; Xgeva; ZOL446; ZOLEDRONIC ACID; Zoledronic Acid; Zoledronic Acid Kern Pharma 4 mg/100 mL solution for infusion, generic medicinal product; Zoledronic Acid Kern Pharma 4 mg/100 mL solution for infusion, generic medicinal product.; Zoledronic Acid Kern Pharma 4 mg/100 mL solution for infusion,generic medicinal product; Zoledronic acid; Zometa; Ácido risedrónico

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04152551 (ClinicalTrials.gov)	November 2, 2019	18/10/2019	Effects of Bisphosphonates on OI-Related Hearing Loss	Effects of Bisphosphonates on OI-Related Hearing Loss: A Pilot Study	Osteogenesis Imperfecta	Drug: Risedronate Oral Tablet	Hospital for Special Surgery, New York	The New York Community Trust;Weill Cornell Medicine;Northwell Health	Recruiting	6 Years	100 Years	All	100	Phase 4	United States
2	NCT03208582 (ClinicalTrials.gov)	April 1, 2017	23/5/2017	Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?	Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?	Osteogenesis Imperfecta	Drug: Risedronate Sodium;Dietary Supplement: Calcichew tablets	Sheffield Children's NHS Foundation Trust	NULL	Completed	4 Years	16 Years	All	13	Phase 2	United Kingdom
3	EUCTR2016-003606-14-GB (EUCTR)	31/01/2017	17/10/2016	Brittle bones - do they react normally after treatment with bisphosphonates?	Do bisphosphonates alter the skeletal response to mechanical stimulation in children with osteogenesis imperfecta? - BAMES study	Osteogenesis Imperfecta MedDRA version: 19.0;Level: PT;Classification code 10031243;Term: Osteogenesis imperfecta;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]	Trade Name: Actonel 5mg Film Coated Tablets Product Name: Actonel 5mg Film Coated Tablets INN or Proposed INN: Risedronate Sodium Trade Name: Actonel Once a Week 35 mg film-coated tablets Product Name: Actonel Once a Week 35 mg film-coated tablets INN or Proposed INN: Risedronate Sodium	Sheffield Children's NHS Foundation Trust	NULL	Not Recruiting			Female: yes Male: yes	15	Phase 2	United Kingdom
4	NCT04115774 (ClinicalTrials.gov)	June 28, 2013	2/10/2019	Registry of Osteogenesis Imperfecta	Registry of Osteogenesis Imperfecta That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Quality of Life Data. Data Are Linked to Patients Biological Sample	Osteogenesis Imperfecta	Drug: bisphosphonates	Luca Sangiorgi	NULL	Enrolling by invitation	N/A	N/A	All	5000		Italy

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT04152551
(ClinicalTrials.gov)

November 2, 2019

18/10/2019

Effects of Bisphosphonates on OI-Related Hearing Loss

Effects of Bisphosphonates on OI-Related Hearing Loss: A Pilot Study

Osteogenesis Imperfecta

Drug: Risedronate Oral Tablet

Hospital for Special Surgery, New York

The New York Community Trust;Weill Cornell Medicine;Northwell Health

Recruiting

6 Years

100 Years

All

100

Phase 4

United States

NCT03208582
(ClinicalTrials.gov)

April 1, 2017

23/5/2017

Do Bisphosphonates Alter the Skeletal Response to Mechanical Stimulation in Children With Osteogenesis Imperfecta?

Osteogenesis Imperfecta

Drug: Risedronate Sodium;Dietary Supplement: Calcichew tablets

Sheffield Children's NHS Foundation Trust

NULL

Completed

4 Years

16 Years

All

Phase 2

United Kingdom

EUCTR2016-003606-14-GB
(EUCTR)

31/01/2017

17/10/2016

Brittle bones - do they react normally after treatment with bisphosphonates?

Do bisphosphonates alter the skeletal response to mechanical stimulation in children with osteogenesis imperfecta? - BAMES study

Osteogenesis Imperfecta
MedDRA version: 19.0;Level: PT;Classification code 10031243;Term: Osteogenesis imperfecta;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]

Trade Name: Actonel 5mg Film Coated Tablets
Product Name: Actonel 5mg Film Coated Tablets
INN or Proposed INN: Risedronate Sodium
Trade Name: Actonel Once a Week 35 mg film-coated tablets
Product Name: Actonel Once a Week 35 mg film-coated tablets
INN or Proposed INN: Risedronate Sodium

Sheffield Children's NHS Foundation Trust

NULL

Not Recruiting

Female: yes
Male: yes

Phase 2

United Kingdom

NCT04115774
(ClinicalTrials.gov)

June 28, 2013

2/10/2019

Registry of Osteogenesis Imperfecta

Registry of Osteogenesis Imperfecta That Collects Clinical, Functional, Genetic, Genealogical, Imaging, Surgical, Quality of Life Data. Data Are Linked to Patients Biological Sample

Osteogenesis Imperfecta

Drug: bisphosphonates

Luca Sangiorgi

NULL

Enrolling by invitation

N/A

All

5000

Italy