DDrare: Database of Drug Development for Rare Diseases

Searched query = "Huge venous malformation with cervical, oral and pharyngeal diffuse lesion", "Huge venous malformation", "Venous malformation"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = Alcohol; Bleomycin; Bleomycin + Fibrovein; Bleomycin Baxter; Dehydrated Alcohol (Absolute Alcohol) BP for Injection; ETHANOL (96 PER CENT); ETHANOL BP; Ethanol; Ethanol 96% Gel; Ethanol 98% Solution; Ethanol gel; Ethanolamine; Ethanolamine oleate; Fibrovein; Fibrovein 3%; Iopamiron; L0122; Polidocanol; Rapamycin; Sirolimus; Trametinib; Trametinib tablet; VT30

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03767660 (ClinicalTrials.gov)	July 31, 2018	24/11/2018	Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation	Efficacy of Rapamycin (Sirolimus) in the Treatment of Blue Rubber Bleb Nevus Syndrome, Hereditary or Sporadic Venous Malformation	Blue Rubber Bleb Nevus Syndrome;Venous Malformation	Drug: Rapamycin	Peking Union Medical College Hospital	Air Force General Hospital of the PLA;Chinese Academy of Medical Sciences	Recruiting	N/A	N/A	All	20	Phase 4	China
2	NCT00975819 (ClinicalTrials.gov)	October 2009	10/9/2009	Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies	A Phase 2 Study - Clinical Trial Assessing Efficacy and Safety of the mTOR Inhibitor Sirolimus in the Treatment of Complicated Vascular Anomalies	Kaposiform Hemangioendotheliomas;Tufted Angioma;Capillary Venous Lymphatic Malformation;Venous Lymphatic Malformation;Microcystic Lymphatic Malformation;Mucocutaneous Lymphangiomatosis and Thrombocytopenia;Capillary Lymphatic Arterial Venous Malformations;PTEN Overgrowth Syndrome With Vascular Anomaly;Lymphangiectasia Syndromes	Drug: sirolimus	Children's Hospital Medical Center, Cincinnati	NULL	Active, not recruiting	N/A	31 Years	Both	60	Phase 2	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT03767660
(ClinicalTrials.gov)

July 31, 2018

24/11/2018

Efficacy of Rapamycin (Sirolimus) in the Treatment of BRBNS, Hereditary or Sporadic Venous Malformation

Efficacy of Rapamycin (Sirolimus) in the Treatment of Blue Rubber Bleb Nevus Syndrome, Hereditary or Sporadic Venous Malformation

Blue Rubber Bleb Nevus Syndrome;Venous Malformation

Drug: Rapamycin

Peking Union Medical College Hospital

Air Force General Hospital of the PLA;Chinese Academy of Medical Sciences

Recruiting

N/A

All

Phase 4

China

NCT00975819
(ClinicalTrials.gov)

October 2009

10/9/2009

Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies

A Phase 2 Study - Clinical Trial Assessing Efficacy and Safety of the mTOR Inhibitor Sirolimus in the Treatment of Complicated Vascular Anomalies

Kaposiform Hemangioendotheliomas;Tufted Angioma;Capillary Venous Lymphatic Malformation;Venous Lymphatic Malformation;Microcystic Lymphatic Malformation;Mucocutaneous Lymphangiomatosis and Thrombocytopenia;Capillary Lymphatic Arterial Venous Malformations;PTEN Overgrowth Syndrome With Vascular Anomaly;Lymphangiectasia Syndromes

Drug: sirolimus

Children's Hospital Medical Center, Cincinnati

NULL

Active, not recruiting

N/A

31 Years

Both

Phase 2

United States