6. Parkinson disease
2,123 clinical trials, 2,046 drugs (DrugBank: 324 drugs), 183 drug target genes, 198 drug target pathways
Searched query = "Parkinson disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ChiCTR2000038937 | 2020-11-01 | 2020-10-10 | Clinical study of early diagnosis of Parkinson's disease based on substantia nigra-striatal axis multimodal imaging | Clinical study of early diagnosis of Parkinson's disease based on substantia nigra-striatal axis multimodal imaging | Parkinson's disease | Gold Standard:Clinical diagnosis by experienced movement disorder specialists after 2 years of follow-up.;Index test:Including traditional imaging feature algorithms (SUVR value, total cortical volume, bilateral cortical surface area, cortical thickness, etc.), high-dimensional imaging omics feature algorithms (energy entropy, gray-level co-occurrence matrix, and mutual information, etc.), and brain connection group Learning feature algorithm.; | Huashan Hospital, Fudan University | NULL | Recruiting | 45 | 80 | Both | Target condition:105;Difficult condition:0 | China | |
| 2 | ChiCTR2000037239 | 2020-10-01 | 2020-08-27 | Construction and application of a diagnostic marker for Parkinson's disease based on gut microbiomics | Construction and application of a diagnostic marker for Parkinson's disease based on gut microbiomics | Parkinson's disease | Gold Standard:All patients satisfied the United Kingdom Parkinson's Disease Society Brain Bank criteria;Index test:Microbial gene detection chip; | Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | NULL | Recruiting | 55 | 80 | Both | Target condition:500;Difficult condition:600 | China | |
| 3 | ChiCTR2000036006 | 2020-10-01 | 2020-08-21 | The applications of multi- MRI in early diagnosis of Parkinson's Disease based on deep learning | The applications of multi- MRI in early diagnosis of Parkinson's Disease based on deep learning | Parkinson's disease | Gold Standard:MDS clinical diagnostic criteria for Parkinson’s disease;Index test:multimodal MRI features in locus coeruleus and substantia nigra; | Zhongshan Hospital, Fudan University | NULL | Pending | 18 | 85 | Both | Target condition:400;Difficult condition:0 | China | |
| 4 | ChiCTR2000037856 | 2020-10-01 | 2020-09-02 | Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA) | Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA) | Parkinson's Disease | Gold Standard:DAT-PET and 18F-FDG PET ;Index test:a-synuclein protein misfolding cyclic amplification; | Huashan Hospital Affiliated to Fudan University | NULL | Recruiting | 50 | 75 | Both | Target condition:150;Difficult condition:76 | China | |
| 5 | ChiCTR2000036137 | 2020-10-01 | 2020-08-21 | Clinical study of 18F-FDG combined with 18F-AV-133 PET/CT imaging in the diagnosis and differentiation of primary Parkinson's disease | Clinical study of 18F-FDG combined with 18F-AV-133 PET/CT imaging in the diagnosis and differentiation of primary Parkinson's disease | Parkinson’s disease | Gold Standard:UK Parkinson's disease Society Brain Bank Clinical Diagnosis Criteria;Index test:18F-FDG combined with 18F-AV-133 PET/CT imaging; | Renji Hospital (South Court), School of Medicine, Shanghai Jiao Tong University | NULL | Pending | Both | Target condition:50;Difficult condition:0 | China | |||
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 6 | ChiCTR2000032616 | 2020-05-30 | 2020-05-04 | Assistant diagnosis machinery system development based on speech and movement sensitive device for Parkinson's disease | Parkinson's disease, Assistant diagnosis machinery system, speech, movement sensitive device | Parkinson's disease | Gold Standard:clinical outcome meet 2015 MDS-probable PD criteria;Index test:Acoustic receptive and analysis device,Wearable movement sensor; | Shanghai Jiao Tong University School of Medicine affiliated Shanghai General Hospital | NULL | Pending | Both | Target condition:20;Difficult condition:80 | China | |||
| 7 | NCT03815916 (ClinicalTrials.gov) | December 19, 2019 | 18/1/2019 | 31P-MRS Imaging to Assess the Effects of CNM-Au8 on Impaired Neuronal Redox State in Parkinson's Disease | A Phase 2, Pilot Open Label, Sequential Group, Investigator Blinded Study of Magnetic Resonance Spectroscopy (31P-MRS) to Assess the Effects of CNM-Au8 for the Bioenergetic Improvement of Impaired Neuronal Redox State in Parkinson's Disease | Parkinson's Disease | Drug: Gold Nanocrystals | Clene Nanomedicine | University of Texas Southwestern Medical Center | Recruiting | 30 Years | 80 Years | All | 30 | Phase 2 | United States |
| 8 | ChiCTR1900027306 | 2019-11-15 | 2019-11-08 | Application of optical coherence tomography and detection of a-synuclein in tears in the diagnosis of Parkinson's disease | Morphological changes of retina in patients with Parkinson's disease and the role of a-synuclein in retinal damage | Parkinson's disease | Gold Standard:British brain bank Parkinson's disease diagnostic criteria;Index test:Application of optical coherence tomography to observe the retinal structure of the macular area, optic disc area and the expression level of a-synuclein in tears in the diagnosis of Parkinson's disease.; | The First Affiliated Hospital of Chengdu Medical College | NULL | Recruiting | Both | Target condition:85;Difficult condition:85 | China | |||
| 9 | ChiCTR1800015757 | 2019-04-01 | 2018-04-18 | Value of 131I-MIBG salivary gland imaging in the early diagnosis of Parkinson's disease | Value of 131I-MIBG salivary gland imaging in the early diagnosis of Parkinson's disease | Parkinson's Disease | Gold Standard:PD diagnostic criteria made by MDS in 2016;Index test:reduced uptake in salivery gland and myocardium in I-131-MIBG scintigraphic imaging; | Tongji hospital, Tongji University | NULL | Pending | Both | Target condition:30;Difficult condition:30 | China | |||
| 10 | ChiCTR-DDD-16009569 | 2017-01-01 | 2016-10-24 | Differential diagnosis of primary Parkinson's disease by 18F-FDG combined with 11C-ß-CFT PET / CT imaging | Differential diagnosis of primary Parkinson's disease by 18F-FDG combined with 11C-ß-CFT PET / CT imaging | Parkinson's Disease | Gold Standard:;Index test:; | Renji hospital, School of Medicine, Shanghai Jiao Tong University | NULL | Pending | 20 | 80 | Both | Target condition:0;Difficult condition:0 | China | |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
| 11 | ChiCTR-DOC-16008645 | 2016-07-01 | 2016-06-15 | The study of radionuclide imaging and biomarkers in clinical diagnosis and treatment of Parkinson's disease | The study of radionuclide imaging and biomarkers in clinical diagnosis and treatment of Parkinson's disease | Parkinson Disease | Gold Standard:;Index test:; | 101th Hospital of PLA | NULL | Pending | 18 | 80 | Both | Target condition:0;Difficult condition:0 | NULL | |
| 12 | ChiCTR-DRD-16008778 | 2016-07-01 | 2016-07-04 | The study of Parkinson's disease imaging biomarkers based on MR with high resolution and multi mode | The study of Parkinson's disease imaging biomarkers based on MR with high resolution and multi mode | Parkinson`s Disease | Gold Standard:;Index test:; | Xiangyang Hospital, Hubei University of Medicine | NULL | Recruiting | Both | Target condition:0;Difficult condition:0 | China | |||
| 13 | ChiCTR-DOD-15006097 | 2015-03-18 | 2015-03-16 | The diagnostic value of olfactory-evoked potentials in Parkinson'sdisease | The diagnostic value of olfactory-evoked potentials in Parkinson'sdisease | Parkinson's disease | Gold Standard:;Index test:; | Guangdong General Hospital, Guangdong Academy of Medical Sciences | NULL | Recruiting | 50 | 80 | Both | Target condition:0;Difficult condition:0 | China | |
| 14 | ChiCTR-DDD-17010794 | 2014-11-08 | 2017-03-05 | The study on early diagnosis of Parkinson 's disease by transcranial ultrasonography | the study on early diagnosis of Parkinson 's disease by transcranial ultrasonography | Parkinson's Disease | Gold Standard:Diagnosis of Parkinson disease needs to meet 3 or more: unilateral onset;resting tremor;progressive course; long term asymmetry, the most obvious symptoms is the onset side; a good response to levodopa (70% ~ 100%); levodopa induced chorea; a reaction of levodopa lasts 5 years or more; clinical course last;Index test:Laboratory apparatus As shown in Figure 1, The ultrasound equipment, Philips IE33-BOMJH1 color Doppler ultrasonography, Model IE-ELite, with 2-4MHz phased array probe (S5-1 probe) was used for TCS to examine SN in our study. Transcranial ultrasound study Ultrasonography through temporal window, alon; | Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital | NULL | Completed | 36 | 84 | Both | Target condition:135;Difficult condition:0 | China |