DDrare: Database of Drug Development for Rare Diseases

Searched query = "Corticobasal degeneration", "Corticobasal syndrome", "CBD"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 18F-AV-1451; 18F-FDG; 18F-RO6958948; ABBV-8E12; AL; Anti-Parkinson medication; BIIB092; BOTULINUM TOXIN TYPE A; Botulinum toxin type A; Davunetide; Davunetide (AL-108, NAP); Device: Deep Brain Stimulation; Diagnostic Test: Elecsys (Roche) Abeta42, Ttau and Ptau; Diagnostic Test: Flutemetamol F18 Injection; Diagnostic Test: Lumipulse (Fujirebio) Abeta42, Ttau and Ptau; Diagnostic Test: [18F]-RO6958948; Dopamine; Flortaucipir; Flortaucipir F18; Flutemetamol; Flutemetamol F18; Leucine; Lithium; NT 101; Other: 13C6 Leucine; Procedure: Brain PET scan; Raclopride; TPI 287 2 mg/m2; TPI-287 20 mg/m2; TPI-287 6.3 mg/m2; Vizamyl; Vizamyl (flutemetamol(F-18)); Xeomin

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03658135 (ClinicalTrials.gov)	September 12, 2018	13/8/2018	BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES	A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients With Four Different Primary Tauopathy Syndromes	Primary Tauopathies;Corticobasal Degeneration Syndrome;Frontotemporal Lobar Degeneration With Tau Inclusions;MAPT Mutation Carriers, Symptomatic;Traumatic Encephalopathy Syndrome;Nonfluent Aphasia, Progressive	Drug: BIIB092;Other: Placebo	University of California, San Francisco	NULL	Terminated	35 Years	80 Years	All	22	Phase 1	United States

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NCT03658135
(ClinicalTrials.gov)

September 12, 2018

13/8/2018

BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES

A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients With Four Different Primary Tauopathy Syndromes

Primary Tauopathies;Corticobasal Degeneration Syndrome;Frontotemporal Lobar Degeneration With Tau Inclusions;MAPT Mutation Carriers, Symptomatic;Traumatic Encephalopathy Syndrome;Nonfluent Aphasia, Progressive

Drug: BIIB092;Other: Placebo

University of California, San Francisco

NULL

Terminated

35 Years

80 Years

All

Phase 1

United States