96. Crohn disease
2,209 clinical trials,   1,276 drugs   (DrugBank: 240 drugs),   166 drug target genes,   210 drug target pathways

Searched query = "Crohn disease", "Terminal ileitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Search in Page e.g. "Phase 3", "Not recruiting", "Japan"
14 trials found
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04073472
(ClinicalTrials.gov)
December 1, 202023/8/2019Mesenchymal Stem Cells for the Treatment of Pouch Fistulas in Crohn'sA Phase I Study of Allogeneic Bone Marrow Derived Mesenchymal Stem Cells for the Treatment of Ileal Anal Anastomosis and Ileal Pouch Fistulas in the Setting of Crohn's Disease of the PouchCrohn's Disease;Fistula;Anal Fistula;Pouch, Ileal;Pouches, IleoanalDrug: mesenchymal stem cells (MSCs)The Cleveland ClinicNULLNot yet recruiting18 Years75 YearsAll15Phase 1United States
2NCT03449069
(ClinicalTrials.gov)
July 23, 201822/2/2018Pediatric MSC-AFP Sub-study for Crohn's FistulaA Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Fistulizing Crohn's Disease: Pediatric Sub-studyFistula in Ano;Crohn DiseaseDrug: MSC-AFPMayo ClinicNULLRecruiting12 Years17 YearsAll5Phase 1United States
3NCT03901235
(ClinicalTrials.gov)
January 15, 20184/3/2019MSC Intratissular Injection in Crohn Disease PatientsTreatment of Refractory Crohn's Disease Lesions by Local Injection of Mesenchymal Stem CellsEfficacy and SafetyBiological: Mesenchymal Stromal CellsUniversity of LiegeLaboratoire de Thérapie Cellulaire et Génétique from CHU de LiègeRecruiting18 YearsN/AAll60Phase 1;Phase 2Belgium
4NCT03220243
(ClinicalTrials.gov)
October 19, 201714/7/2017Stem Cell Coated Fistula Plug in Patients With Crohn's RVFA Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Rectovaginal Fistulizing Crohn's DiseaseFistula Vagina;Crohn DiseaseDrug: MSC-AFPMayo ClinicNULLCompleted18 Years65 YearsFemale5Phase 1United States
5NCT03014219
(ClinicalTrials.gov)
July 20174/1/2017Phase 1 Crohn's Pediatric Sub-study of MSC AFPA Phase I Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Fistulizing Crohn's Disease: Pediatric Sub-studyPerianal FistulaDrug: Only 1 arm: treatment with MSC-AFPWilliam A. Faubion, M.D.NULLWithdrawn12 Years17 YearsAll0Phase 1United States
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
6NCT03056664
(ClinicalTrials.gov)
January 201724/8/2015The Role of MSC in the Treatment of Fistulas in Patients With Perianal Crohn's DiseaseThe Safety and Efficiacy of Local MSC Injection in the Treatment of Fistulas in Patients With Perianal Crohn's DiseaseCrohn's Disease;FistulaProcedure: Routine drainage surgery;Biological: MSC injection 01;Biological: MSC injection 02;Other: placeboSixth Affiliated Hospital, Sun Yat-sen UniversityNULLNot yet recruiting18 Years65 YearsAll3Phase 2;Phase 3NULL
7NCT02532738
(ClinicalTrials.gov)
January 201623/8/2015The Efficiency of MSC in Refractory Crohn's DiseaseA Stage II Clinical Trial Comparing the Efficiacy of Routine Treatment Combined With or Without MSC Therapy in Refractory Crohn's DiseaseCrohn's DiseaseDrug: Routine Treatment of CD;Biological: MSC treatment 01;Biological: MSC treatment 02;Other: NSSixth Affiliated Hospital, Sun Yat-sen UniversityThird Affiliated Hospital, Sun Yat-Sen University;Nanfang Hospital of Southern Medical UniversityNot yet recruiting18 Years65 YearsBoth3Phase 2;Phase 3NULL
8NCT01915927
(ClinicalTrials.gov)
July 201331/7/2013Stem Cell Fistula Plug in Perianal Crohn's DiseaseA Phase 1 Study of Autologous Mesenchymal Stromal Cell Coated Fistula Plug in Patients With Fistulizing Crohn's Disease.Perianal Crohn's DiseaseDrug: MSC-AFPWilliam A. Faubion, M.D.NULLCompleted18 Years65 YearsAll20Phase 1United States
9NCT01659762
(ClinicalTrials.gov)
July 20126/8/2012A Phase I Study Evaluating Autologous Bone Marrow Derived Mesenchymal Stromal for Crohn's Disease.A Phase I Study Evaluating Safety and Tolerability of Autologous Bone Marrow Derived Mesenchymal Stromal (MSC) Cells in Adults With Moderate to Severe Crohn's Disease.Crohn's DiseaseBiological: autologous mesenchymal stromal cellEmory UniversityAtlanta Clinical and Translational Science Institute;Atlanta Clinical and Translational Science InstituteCompleted18 Years65 YearsBoth16Phase 1United States
10NCT02445547
(ClinicalTrials.gov)
June 201213/5/2015Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's DiseaseUmbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical TrialCrohn DiseaseOther: UC-MSCs by peripheral intravenous infusion;Drug: received hormone maintenance therapyFuzhou General HospitalShaanxi Provincial People's HospitalCompleted18 Years70 YearsAll82Phase 1;Phase 2China
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
11EUCTR2011-005966-39-BE
(EUCTR)
08/03/201212/12/2011Therapeutic effect of mesenchymal cells in patients suffering from a disease characterized by a severe inflammation and/or in whom the immune system attacks their own tissues.Mesenchymal stem cell therapy for the treatment of severe or refractory inflammatory and/or autoimmune disorders. Crohn's disease
MedDRA version: 14.0;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 10017947 - Gastrointestinal disorders
MedDRA version: 14.0;Level: HLGT;Classification code 10003816;Term: Autoimmune disorders;System Organ Class: 10021428 - Immune system disorders
MedDRA version: 14.0;Level: PT;Classification code 10064147;Term: Gastrointestinal inflammation;Classification code 10011401;Term: Crohn's disease;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: mesenchymal stem cells
Product Code: MSC
CHU-ULgNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
20Belgium
12NCT01540292
(ClinicalTrials.gov)
March 201222/2/2012Mesenchymal Stem Cell Therapy for the Treatment of Severe or Refractory Inflammatory and/or Autoimmune DisordersMesenchymal Stem Cell Therapy for the Treatment of Severe or Refractory Inflammatory and/or Autoimmune DisordersCrohn's DiseaseBiological: Mesenchymal Stem Cells (MSC)University Hospital of LiegeNULLRecruiting18 Years75 YearsBoth20Phase 1;Phase 2Belgium
13EUCTR2009-015680-14-NL
(EUCTR)
18/05/201027/07/2010Allogeneic Bone Marrow Derived Mesenchymal Stem Cellsfor the Treatment of Fistulas in Patients withRefractory Perianal Crohn’s Disease - allo bmMSCs CD fistulaAllogeneic Bone Marrow Derived Mesenchymal Stem Cellsfor the Treatment of Fistulas in Patients withRefractory Perianal Crohn’s Disease - allo bmMSCs CD fistula single or multiple draining perianal fistulas as a result of Crohn's Disease
MedDRA version: 12.1;Level: LLT;Classification code 10011401;Term: Crohn's disease
Product Name: Bone Marrow Derived Mesenchymal Stem cells (MSCs)
Product Code: NA
Leiden University Medical CenterNULLNot RecruitingFemale: yes
Male: yes
Netherlands
14NCT01090817
(ClinicalTrials.gov)
January 201022/3/2010An Australian Study of Mesenchymal Stromal Cells for Crohn's DiseaseA Multicentre Australian Phase 2 Study to Evaluate Safety and Efficacy of Mesenchymal Stromal Cells for Treating Biologic Refractory Crohn's DiseaseCrohn DiseaseDrug: Mesenchymal stromal cells (MSC) for infusionR.P.HerrmannThe Queen Elizabeth Hospital;Concord Hospital;Sir Charles Gairdner Hospital;The AlfredCompleted18 Years55 YearsBoth21Phase 2Australia