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Raltegravir    (DrugBank: Raltegravir)

4 diseases
告示番号疾患名（ページ内リンク）臨床試験数
13多発性硬化症／視神経脊髄炎2
26HTLV-1関連脊髄症4
93原発性胆汁性胆管炎［原発性胆汁性肝硬変 (~2017.3)］1
265脂肪萎縮症2

13. 多発性硬化症／視神経脊髄炎　［臨床試験数：3,050，薬物数：2,147（DrugBank：348），標的遺伝子数：244，標的パスウェイ数：228］
Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 3,050 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01767701
(ClinicalTrials.gov)		April 20137/1/2013Raltegravir (Isentress) Pilot Study in Relapsing Multiple SclerosisA Phase II Baseline Versus Treatment Study to Determine the Efficacy of Raltegravir (Isentress) in Preventing Progression of Relapsing Remitting Multiple Sclerosis as Determined by Gadolinium-enhanced MRIRelapsing Remitting Multiple SclerosisDrug: RaltegravirQueen Mary University of LondonMerck Sharp & Dohme Corp.Completed18 Years55 YearsAll23Phase 2United Kingdom
2EUCTR2012-004847-61-GB
(EUCTR)		16/01/201318/12/2012INSPIRE: Raltegravir (Isentress) Pilot Study in Relapsing MSA phase II baseline versus treatment study to determine the efficacy of raltegravir (ISENTRESS) in preventing progression of relapsing remitting multiple sclerosis as determined by gadolinium-enhanced MRI - INSPIRE (Isentress Pilot Study in Relapsing MS) Relapsing Remitting Multiple Sclerosis
MedDRA version: 14.1;Level: PT;Classification code 10063399;Term: Relapsing-remitting multiple sclerosis;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]		Trade Name: ISENTRESS
Product Name: raltegravir
INN or Proposed INN: lactose monohydrate		Queen Mary University of LondonNULLNot RecruitingFemale: yes
Male: yes		24Phase 2United Kingdom

26. HTLV-1関連脊髄症　［臨床試験数：26，薬物数：46（DrugBank：27），標的遺伝子数：37，標的パスウェイ数：123］
Searched query = "HTLV-1-associated myelopathy", "Tropical spastic paraparesis", "HTLV-1", "HTLV-I-associated myelopathy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
4 / 26 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT02655471
(ClinicalTrials.gov)		July 1, 201716/11/2015Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 InfectionEffect of Raltegravir in Patients With Myelopathy/Tropical Spastic Paraparesis Associated With Infection by Human T-Lymphotropic Virus 1 (HTLV-1). Pilot StudyHTLV-I Infections;Tropical Spastic ParaparesisDrug: Raltegravir and ZidovudineUniversidad Peruana Cayetano HerediaMerck Sharp & Dohme Corp.Completed18 YearsN/AAll10Early Phase 1Peru
2NCT01867320
(ClinicalTrials.gov)		September 5, 201321/5/2013Raltegravir for HAM/TSPPilot Study of Raltegravir, an Integrase Inhibitor, in Human T-Cell Lymphotrophic Virus-1(HTLV-1) Associated Myelopathy, Tropical Spastic Paraparesis (HAM/TSP)HTLV-I InfectionDrug: RaltegravirNational Institute of Neurological Disorders and Stroke (NINDS)NULLCompleted18 YearsN/AAll19Early Phase 1United States
3NCT01620736
(ClinicalTrials.gov)		January 201225/1/2012Trial to Assess Effect of Raltegravir on HTLV-1 Proviral LoadPhase II Trial to Assess Effect of Raltegravir on HTLV-1 Proviral LoadHuman T-cell Leukemia Virus Type 1 InfectionDrug: RaltegravirWashington University School of MedicineMerck Sharp & Dohme Corp.Withdrawn18 YearsN/AAll0Phase 2United States
4NCT01000285
(ClinicalTrials.gov)		September 201019/10/2009EPOCH Chemotherapy and Bortezomib for Associated T-Cell Leukemia LymphomaPhase I/II Trial of Dose-Adjusted EPOCH Chemotherapy With Bortezomib Combined With Integrase Inhibitor Therapy for HTLV-1 Associated T-Cell Leukemia LymphomaLeukemia-Lymphoma, Adult T-CellDrug: Bortezomib;Drug: Etoposide;Drug: Vincristine;Drug: Doxorubicin;Drug: Prednisone;Drug: Cyclophosphamide;Drug: RaltegravirWashington University School of MedicineNULLCompleted18 YearsN/AAll18Phase 1;Phase 2United States

93. 原発性胆汁性胆管炎［原発性胆汁性肝硬変 (~2017.3)］　［臨床試験数：230，薬物数：215（DrugBank：51），標的遺伝子数：34，標的パスウェイ数：107］
Searched query = "Primary biliary cholangitis", "Primary biliary cirrhosis", "PBC"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 230 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT03954327
(ClinicalTrials.gov)		September 20207/5/2019Combination Antiretroviral Therapy (cART) for PBCRandomized Controlled Trail (RCT) of Emtricitabine, Tenofovir Disoproxil and Raltegravir for Patients With Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid (UDCA)Primary Biliary CholangitisDrug: Emtricitabine (FTC)/Tenofovir Disoproxil (TDF);Drug: Raltegravir;Drug: Placebo Oral Capsule [CEBOCAP]University of AlbertaMerck Sharp & Dohme Corp.Not yet recruiting18 YearsN/AAll60Phase 2Canada

265. 脂肪萎縮症　［臨床試験数：109，薬物数：164（DrugBank：59），標的遺伝子数：26，標的パスウェイ数：94］
Searched query = "Lipodystrophy", "Berardinelli-Seip syndrome", "Lawrence syndrome", "Barraquer-Simons syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 109 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01164605
(ClinicalTrials.gov)		October 201014/7/2010Pilot Study of Raltegravir Lipodystrophy IISPPilot Study on the Efficacy of a Two Drug, Raltegravir-based Regimen,(NRTI) Sparing Antiretroviral TreatmentHIV InfectionDrug: RaltegravirSouthern California Institute for Research and EducationMerck Sharp & Dohme Corp.RecruitingN/AN/ABoth30N/AUnited States
2NCT00656175
(ClinicalTrials.gov)		September 20082/4/2008Raltegravir Therapy for Women With HIV and Fat AccumulationPhase II Study of Raltegravir as Replacement for Protease Inhibitor or Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Based Antiretroviral Therapy in Women With Fat AccumulationHIV Infections;LipodystrophyDrug: raltegravirUniversity of California, Los AngelesMerck Sharp & Dohme Corp.;Case Western Reserve University;Vanderbilt University;Tufts University;University Health Network, TorontoCompleted18 YearsN/AFemale39Phase 2United States;Canada

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