Montelukast, flurbiprofen, midazolam, digoxin, pravastatin and bms-986142 (DrugBank: Pravastatin, Digoxin, Montelukast, Midazolam, Flurbiprofen, BMS-986142)
11 diseases告示番号 | 疾患名(ページ内リンク) | 臨床試験数 |
---|---|---|
2 | 筋萎縮性側索硬化症 | 0 |
3 | 脊髄性筋萎縮症 | 0 |
6 | パーキンソン病 | 0 |
13 | 多発性硬化症/視神経脊髄炎 | 0 |
21 | ミトコンドリア病 | 0 |
46 | 悪性関節リウマチ | 1 |
70 | 広範脊柱管狭窄症 | 0 |
96 | クローン病 | 0 |
97 | 潰瘍性大腸炎 | 0 |
231 | α1-アンチトリプシン欠乏症 | 0 |
298 | 遺伝性膵炎 | 0 |
No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | NCT02456844 (ClinicalTrials.gov) | May 2015 | 27/5/2015 | Study to Investigate the Effect of BMS-986142 on the Pharmacokinetics (PK) of Methotrexate and Probe Substrate Cocktail in Healthy Patients | Effects of BMS-986142 on the Single-dose Pharmacokinetics of Methotrexate and Probe Substrates Montelukast (CYP2C8), Flurbiprofen (CYP2C9), Midazolam (CYP3A4), Digoxin (P-gp), and Pravastatin (OATP1B1) in Healthy Subjects | Rheumatoid Arthritis | Drug: Montelukast, Flurbiprofen, Midazolam, Digoxin, Pravastatin and BMS-986142;Drug: Methotrexate, Leucovorin and BMS-986142 | Bristol-Myers Squibb | NULL | Completed | 18 Years | 50 Years | Both | 24 | Phase 1 | NULL |