DDrare: Database of Drug Development for Rare Diseases

Resveratrol (DrugBank: Resveratrol)

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	1
8	ハンチントン病	1
18	脊髄小脳変性症（多系統萎縮症を除く。）	2
89	リンパ脈管筋腫症	1
113	筋ジストロフィー	1
299	嚢胞性線維症	1

2. 筋萎縮性側索硬化症　［臨床試験数：508，薬物数：530（DrugBank：146），標的遺伝子数：170，標的パスウェイ数：221］

Searched query = "Amyotrophic lateral sclerosis", "ALS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 508 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04654689 (ClinicalTrials.gov)	January 2021	13/11/2020	Impact of the Combined Treatment of Liposomed Polyphenols With Dutasteride on the ALS Patients	Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With Dutasteride on the Clinical Improvement of ALS Patients	Amyotrophic Lateral Sclerosis	Dietary Supplement: Liposomed polyphenols resveratrol and curcumin;Other: Placebo for liposomed resveratrol and curcumin;Dietary Supplement: Isocaloric Diet;Drug: Dutasteride 0.5 mg;Other: Placebo microcrystalline methylcellulose	Fundación Universidad Católica de Valencia San Vicente Mártir	NULL	Not yet recruiting	18 Years	75 Years	All	100	Phase 2	Spain

8. ハンチントン病　［臨床試験数：197，薬物数：171（DrugBank：54），標的遺伝子数：82，標的パスウェイ数：144］

Searched query = "Huntington disease", "Huntington chorea"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 197 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02336633 (ClinicalTrials.gov)	July 2015	8/1/2015	Resveratrol and Huntington Disease	Metabolic Intervention Using Resveratrol in Patients With Huntington Disease	Huntington Disease	Dietary Supplement: Resveratrol;Other: Placebo	Assistance Publique - Hôpitaux de Paris	NULL	Completed	18 Years	N/A	All	102	N/A	France

18. 脊髄小脳変性症（多系統萎縮症を除く。）　［臨床試験数：59，薬物数：78（DrugBank：28），標的遺伝子数：44，標的パスウェイ数：59］

Searched query = "Spinocerebellar degeneration", "SCD", "Spinocerebellar ataxia type I", "SCA1", "Spinocerebellar ataxia type II", "SCA2", "Spinocerebellar ataxia type III", "SCA3", "Machado-Joseph disease", "Spinocerebellar ataxia type VI", "SCA6", "Spinocerebellar ataxia type VII", "SCA7", "Spinocerebellar ataxia type X", "SCA10", "Spinocerebellar ataxia type XII", "SCA12", "Dentatorubural pallidoluysian atrophy", "Dentatorubropallidoluysial atrophy", "DRPLA", "Naito-Koyanagi disease", "Friedreich ataxia", "FRDA", "Ataxia with vitamin E deficiency", "AVED", "Early-onset ataxia with ocular motor ataxia and hypoalbuminemia", "EOAH"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

2 / 59 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03933163 (ClinicalTrials.gov)	May 23, 2019	16/4/2019	Micronised Resveratrol as a Treatment for Friedreich Ataxia	A Randomised Placebo-controlled Crossover Trial of Micronised Resveratrol as a Treatment for Friedreich Ataxia	Friedreich Ataxia	Drug: Resveratrol	Murdoch Childrens Research Institute	NULL	Recruiting	16 Years	N/A	All	40	Phase 2	Australia
2	NCT01339884 (ClinicalTrials.gov)	April 2011	14/4/2011	A Study of Resveratrol as Treatment for Friedreich Ataxia	An Open Label Clinical Pilot Study of Resveratrol as Treatment for Friedreich Ataxia	Friedreich Ataxia	Drug: Resveratrol	Murdoch Childrens Research Institute	Friedreich's Ataxia Research Alliance	Completed	18 Years	N/A	Both	27	Phase 1;Phase 2	Australia

89. リンパ脈管筋腫症　［臨床試験数：38，薬物数：42（DrugBank：19），標的遺伝子数：26，標的パスウェイ数：134］

Searched query = "Lymphangioleiomyomatosis", "LAM"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 38 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03253913 (ClinicalTrials.gov)	March 31, 2018	10/8/2017	Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial	Resveratrol and Sirolimus in Lymphangioleiomyomatosis Trial (RESULT)	Lymphangioleiomyomatosis	Drug: Sirolimus;Drug: Resveratrol	University of Cincinnati	National Heart, Lung, and Blood Institute (NHLBI)	Unknown status	18 Years	N/A	Female	25	Phase 2	United States

113. 筋ジストロフィー　［臨床試験数：567，薬物数：442（DrugBank：93），標的遺伝子数：55，標的パスウェイ数：151］

Searched query = "Muscular dystrophy", "Dystrophinopathies", "Myotilinopathy", "Laminopathy", "Caveolinopathy", "LGMD1C", "Desminopathy", "Sarcoglycanopathy", "α-dystroglycanopathy", "FCMD", "Walker-Warburg syndrome", "Muscle-eye-brain disease", "Myotonic dystrophy", "Integrin α7 deficient CMD", "Rigid spine syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 567 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000014836	2014/05/01	12/08/2014	A pilot study to evaluate efficacy and safety of resveratrol for muscular dystrophy.		Duchenne muscular dystrophy, Becker muscular dystrophy, Fukuyama congenital muscular dystrophy	500mg resveratrol is administrated daily for 8 weeks. Subsequently, resveratrol is increased to 1500mg by 500mg every 8 weeks.	Sapporo Medical University	NULL	Complete: follow-up complete	12years-old	Not applicable	Male and Female	10	Not selected	Japan

299. 嚢胞性線維症　［臨床試験数：1,592，薬物数：1,539（DrugBank：255），標的遺伝子数：81，標的パスウェイ数：162］

Searched query = "Cystic fibrosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 1,592 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04166396 (ClinicalTrials.gov)	February 17, 2020	14/11/2019	Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis	Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis	Cystic Fibrosis	Dietary Supplement: Resveratrol;Dietary Supplement: NR;Dietary Supplement: Placebo	Virginia Commonwealth University	NULL	Active, not recruiting	18 Years	N/A	All	36	N/A	United States

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