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Methionine    (DrugBank: Methionine)

7 diseases
告示番号疾患名（ページ内リンク）臨床試験数
34神経線維腫症1
75クッシング病1
84サルコイドーシス2
93原発性胆汁性胆管炎［原発性胆汁性肝硬変 (~2017.3)］2
229肺胞蛋白症（自己免疫性又は先天性）1
298遺伝性膵炎1
300IgG4関連疾患1

34. 神経線維腫症　［臨床試験数：120，薬物数：182（DrugBank：72），標的遺伝子数：84，標的パスウェイ数：194］
Searched query = "Neurofibromatosis", "NF1", "von Recklinghausen disease", "NF2"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 120 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1EUCTR2010-019759-23-GB
(EUCTR)		12/01/201113/12/2010Evaluation of [11C]-methionine positron emission computerised tomography (PET CT) in diagnosing neurofibromatosis 1(NF1) - malignant peripheral nerve sheath tumours (MPNST) - Methionine PETEvaluation of [11C]-methionine positron emission computerised tomography (PET CT) in diagnosing neurofibromatosis 1(NF1) - malignant peripheral nerve sheath tumours (MPNST) - Methionine PET The diagnosis of malignant peripheral nerve sheath tumours in patients with neurofibromatosis 1
MedDRA version: 12;Level: LLT;Classification code 10029268;Term: Neurofibromatosis 1 associated malignant peripheral nerve sheath tumour		Product Name: [11C]-methionine
INN or Proposed INN: 2-amino-4-(methyl[11C]sulfanyl)butanoic acid
Other descriptive name: Methionine		Guys' and St. Thomas' NHS Foundation TrustNULLNot RecruitingFemale: yes
Male: yes		United Kingdom

75. クッシング病　［臨床試験数：191，薬物数：172（DrugBank：48），標的遺伝子数：61，標的パスウェイ数：121］
Searched query = "Cushing disease", "Cushing"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 191 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT03346954
(ClinicalTrials.gov)		December 11, 201715/11/2017Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's DiseaseImpact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's DiseaseCushing's DiseaseOther: [11C]-Methionine PET/MRIHospices Civils de LyonNULLCompleted18 YearsN/AAll33N/AFrance

84. サルコイドーシス　［臨床試験数：143，薬物数：221（DrugBank：79），標的遺伝子数：82，標的パスウェイ数：165］
Searched query = "Sarcoidosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 143 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT02824419
(ClinicalTrials.gov)		May 201627/5/2016Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary SarcoidosisImaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary SarcoidosisPulmonary SarcoidosisDrug: Methionine;Drug: DOTANOCTurku University HospitalNULLRecruiting18 YearsN/ABoth10Phase 2;Phase 3Finland
2EUCTR2015-001815-11-FI
(EUCTR)		19/04/201629/12/2015PET imaging of pulmonary sarcoidosisImaging of active granulomas with [18F]FDG and selected inflammatory PET tracers in pulmonary sarcoidosis Pulmonary sarcoidosis with active garnulomas in the lungs. The diagnosis is based on the clinical evidence or biopsy.
MedDRA version: 18.1;Level: PT;Classification code 10037430;Term: Pulmonary sarcoidosis;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]		Product Name: 18F-fluorodeoxyglucose
Product Code: FDG
INN or Proposed INN: FLUORINE (18F) FLUDEOXYGLUCOSE
Product Name: C11-methionine
INN or Proposed INN: L-methionine
Other descriptive name: L-METHIONINE ([11C]METHYL)
Product Name: 68Ga-DOTANOC
INN or Proposed INN: DOTANOC
Other descriptive name: DOTANOC		Turku PET CentreNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes		Finland

93. 原発性胆汁性胆管炎［原発性胆汁性肝硬変 (~2017.3)］　［臨床試験数：230，薬物数：215（DrugBank：51），標的遺伝子数：34，標的パスウェイ数：107］
Searched query = "Primary biliary cholangitis", "Primary biliary cirrhosis", "PBC"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 230 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT02557360
(ClinicalTrials.gov)		November 201521/9/2015Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary CirrhosisEffectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary CirrhosisPrimary Biliary CirrhosisDietary Supplement: S-adenosyl-L-methioninePomeranian Medical University SzczecinLaval UniversityCompletedN/AN/AAll24Phase 4Poland
2NCT00125281
(ClinicalTrials.gov)		July 25, 200529/7/2005SAMe to Treat Biliary Cirrhosis SymptomsS-Adenosyl Methionine for Symptomatic Treatment of Primary Biliary CirrhosisLiver Cirrhosis, BiliaryDrug: S-adenosyl-methionine (SAMe) capsulesNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLTerminated21 YearsN/AAll50Phase 2United States

229. 肺胞蛋白症（自己免疫性又は先天性）　［臨床試験数：35，薬物数：30（DrugBank：8），標的遺伝子数：3，標的パスウェイ数：12］
Searched query = "Autoimmune pulmonary alveolar proteinosis", "Congenital pulmonary alveolar proteinosis", "Hereditary pulmonary alveolar proteinosis", "Pulmonary alveolar proteinosis", "PAP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 35 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT03887169
(ClinicalTrials.gov)		September 16, 201912/3/2019Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.Pulmonary Alveolar Proteinosis;Mutation Ala393Thr of the MARS Gene;mutationSer567Leu of the MARS GeneDrug: Methionine;Drug: Vitamin B12, B9, B6, C supplementation;Diagnostic Test: Methionine/homocysteine Dosage;Diagnostic Test: Thoracic CT scan;Diagnostic Test: Abdominal and liver ultrasound.;Diagnostic Test: Brain MRIAssistance Publique - Hôpitaux de ParisNULLCompletedN/A18 YearsAll3Phase 1;Phase 2France

298. 遺伝性膵炎　［臨床試験数：93，薬物数：168（DrugBank：51），標的遺伝子数：48，標的パスウェイ数：134］
Searched query = "Hereditary pancreatitis", "Chronic pancreatitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 93 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1EUCTR2006-000087-83-GB
(EUCTR)		19/12/200804/12/2007EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2 Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis
MedDRA version: 13.1;Level: HLT;Classification code 10033646;Term: Acute and chronic pancreatitis;System Organ Class: 10017947 - Gastrointestinal disorders
MedDRA version: 13.1;Level: PT;Classification code 10056976;Term: Hereditary pancreatitis;System Organ Class: 10010331 - Congenital, familial and genetic disorders		Trade Name: Magnesiocard 2.5mmol
Other descriptive name: MAGNESIUM ASPARTATE HYDROCHLORIDE
Product Name: ANTOX (vers) 1.2
Product Code: ANTOX
Other descriptive name: TOCOPHEROL
INN or Proposed INN: ASCORBIC ACID
Other descriptive name: SELENIUM
INN or Proposed INN: METHIONINE		University of LiverpoolThe Royal Liverpool and Broadgreen University Hospitals NHS TrustAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes		240Phase 3United Kingdom

300. IgG4関連疾患　［臨床試験数：31，薬物数：33（DrugBank：16），標的遺伝子数：11，標的パスウェイ数：81］
Searched query = "IgG4-related disease", "Autoimmune pancreatitis", "IgG4-related sclerosing cholangitis", "IgG4-related lacrimal gland, orbital, and salivary gland lesions", "IgG4-related kidney disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 31 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1JPRN-UMIN000019908
2016/01/0101/01/2016Preliminary study of [11C]methionine PET/CT in the diagnosis of IgG4 related disease IgG4 related disease[11C]methionine PET/CT, [18F]FDG PET/CTSaitama Medical University International Medical CenterSaitama Medical University HospitalComplete: follow-up complete20years-oldNot applicableMale and Female30Not selectedJapan

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