Tranexamic acid (DrugBank: Tranexamic acid)
5 diseases| 告示番号 | 疾患名（ページ内リンク） | 臨床試験数 |
|---|---|---|
| 46 | 悪性関節リウマチ | 4 |
| 70 | 広範脊柱管狭窄症 | 3 |
| 215 | ファロー四徴症 | 1 |
| 227 | オスラー病 | 2 |
| 288 | 自己免疫性後天性凝固因子欠乏症［自己免疫性出血病XIII (~2017.3)］ | 5 |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ChiCTR1900025013 | 2019-08-08 | 2019-08-07 | Clinical observation of multiple dose use of tranexamic acid in patients with rheumatoid arthritis after total knee arthroplasty | Effects of multiple dose use of tranexamic acid on blood loss and inflammatory factors after total knee arthroplasty in patients with rheumatoid arthritis | Total knee arthroplasty | group 1:Intravenous infusion of 1g of tranexamic acid at 3 hours after surgery ;group 2:Intravenous infusion of 1g of tranexamic acid at 3, 6, and 12 hours after surgery; | Guanghua Hospital of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai University of Traditional Chinese Medicine | NULL | Recruiting | 50 | 75 | Both | group 1:52;group 2:52; | Phase 4 | China |
| 2 | JPRN-UMIN000030237 | 2018/01/01 | 03/12/2017 | Additional postoperative intravenous tranexamic acid administration versus placebo administration for patients treated with intraoperative combined intravenous and intra-articular tranexamic acid in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial | Additional postoperative intravenous tranexamic acid administration versus placebo administration for patients treated with intraoperative combined intravenous and intra-articular tranexamic acid in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial - Additional postoperative intravenous tranexamic acid administration versus placebo in total knee arthroplasty | Osteoarthritis of the knee, rheumatoid arthritis, avascular necrosis | Additional postoperative intravenous tranexamic acid group: Patients received 1000 mg of tranexamic acid administered intravenously just before skin incision and 1000 mg of tranexamic acid administered intra-articularly after closure of the capsule and retinaculum. In addition, patients received 1000mg/100mL of tranexamic acid administered intravenously 6 hours after the first intravenous administration of tranexamic acid, and 08:00 and 20:00 one day after surgery. Placebo group: Patients received 1000 mg of tranexamic acid administered intravenously just before skin incision and 1000 mg of tranexamic acid administered intra-articularly after closure of the capsule and retinaculum. Patients received 100 mL of normal saline administered intravenously 6 hours after the first intravenous administration of tranexamic acid, and 08:00 and 20:00 one day after surgery. | Hokusuikai Kinen Hospital | NULL | Complete: follow-up complete | 20years-old | Not applicable | Male and Female | 100 | Not selected | Japan |
| 3 | JPRN-UMIN000029797 | 2017/11/02 | 02/11/2017 | Intravenous versus combined intravenous and intra-articular tranexamic acid for simultaneous bilateral total hip arthroplasty: randomized controlled trial | Intravenous versus combined intravenous and intra-articular tranexamic acid for simultaneous bilateral total hip arthroplasty: randomized controlled trial - Intravenous versus combined intravenous and intra-articular tranexamic acid for simultaneous bilateral total hip arthroplasty: randomized controlled trial | Osteoarthritis of the hip, Avascular necrosis of the femoral head, Rheumatoid arthritis | The combined tranexamic acid group received 1000 mg of tranexamic acid administered intravenously just before skin incision of the first hip. After closure of fascia, 1000 mg of tranexamic acid (10 mL of 100 mg/mL tranexamic acid) was administered intra-articularly for each hip. Five hours after the first intravenous administration of tranexamic acid, 1000 mg of tranexamic acid was again given intravenously. The intravenous tranexamic acid group received 1000 mg of tranexamic acid administered intravenously just before skin incision of the first hip. After closure of the fascia, 10 mL of normal saline was administered intra-articularly for each hip. Five hours after the first intravenous administration of tranexamic acid, 1000 mg of tranexamic acid was again given intravenously. | Hokusuikai Kinen Hospital | NULL | Complete: follow-up complete | 18years-old | Not applicable | Male and Female | 40 | Not selected | Japan |
| 4 | EUCTR2009-012141-34-GB (EUCTR) | 29/06/2009 | 15/05/2009 | Randomised Controlled Trial of the Use of Topical Application of Tranexamic Acid in Primary Total Hip Replacement. - (TRANX-H) | Randomised Controlled Trial of the Use of Topical Application of Tranexamic Acid in Primary Total Hip Replacement. - (TRANX-H) | Blood loss in total hip replacement in patient with ostoearthritis and rheumatoid arthritis. | Trade Name: Cyklokapron® Product Name: Cyklokapron® Product Code: NA | University Hospital of North Tees and Hartlepool | NULL | Not Recruiting | Female: yes Male: yes | 150 | United Kingdom |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT03553186 (ClinicalTrials.gov) | July 11, 2018 | 29/5/2018 | Tranexamic Acid in Adult Spinal Deformity Surgery | Topical Tranexamic Acid as a Adjunct to Intravenous Tranexamic Acid in Adult Spinal Deformity Surgery | Spinal Deformity;Degenerative Lumbar Spinal Stenosis;Blood Loss, Surgical | Drug: Tranexamic Acid 100 MG/ML;Drug: Placebo | Hospital for Special Surgery, New York | NULL | Recruiting | 18 Years | 80 Years | All | 100 | Phase 3 | United States |
| 2 | NCT03011866 (ClinicalTrials.gov) | February 2017 | 16/12/2016 | Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries | Intravenous Versus Topical Use of Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS) : A Prospective, Randomized, Double Blind, Head-to-head Comparison Study | Spinal Stenosis;Intervertebral Disc Displacement | Drug: Wound topically irrigated with 500mg TXA;Drug: 1mg/kg/hr TXA intravenous infusion till the last suture | Peking Union Medical College Hospital | NULL | Not yet recruiting | 50 Years | N/A | All | 176 | N/A | NULL |
| 3 | NCT02063035 (ClinicalTrials.gov) | August 2012 | 19/12/2013 | Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery | Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery | Lumbar Spinal Stenosis;Thoracic Spinal Stenosis | Drug: Tranexamic Acid;Drug: Placebo | Massachusetts General Hospital | NULL | Completed | 18 Years | 85 Years | All | 29 | Phase 4 | United States |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ChiCTR1800019578 | 2018-12-01 | 2018-11-18 | Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgery | Effects of different tranexamic acid regimen in cyanotic pediatric cardiac surgery | Tetralogy of Fallot | Conventional treatment group:Childen did not receive an antifibrinolytic agent during surgery;Low dose of tranexamic acid group:Loading dose: 10mg/kg (infant), 5mg/kg (children); Infusion: 2mg/kg.h; CPB prime dose: 20ug/mL of prime volume;High dose of tranexamic acid group:Loading dose: 30mg/kg (infant), 15mg/kg (children); Infusion: 6mg/kg.h; CPB prime dose: 60ug/mL of prime volume; | National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College | NULL | Pending | Both | Conventional treatment group:225;Low dose of tranexamic acid group:225;High dose of tranexamic acid group:225; | China |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT01408030 (ClinicalTrials.gov) | August 2011 | 1/8/2011 | North American Study of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) | North American Study of Epistaxis in HHT (NOSE) | Telangiectasia, Hereditary Hemorrhagic;Epistaxis | Drug: Sterile saline;Drug: Bevacizumab;Drug: Estriol;Drug: Tranexamic Acid | James Gossage | HHT Foundation International | Completed | 18 Years | N/A | All | 123 | Phase 2 | United States |
| 2 | NCT01031992 (ClinicalTrials.gov) | March 2002 | 11/12/2009 | Tranexamic Acid and Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) | Efficacy of Tranexamic Acid Taken Orally in Patients With Hereditary Hemorrhagic Telangiectasia | Hereditary Hemorrhagic Telangiectasia | Drug: Tranexamic acid first, than placebo;Drug: First placebo, than Tranexamic acid. | University Hospital, Saarland | Pharmacia GmbH, Erlangen, Germany;Baxter Healthcare Corporation | Completed | 18 Years | N/A | Both | 23 | Phase 3 | Germany |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04344860 (ClinicalTrials.gov) | February 1, 2021 | 9/4/2020 | Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial | Prospective, Randomized Trial Comparing Recombinant Von Willebrand Factor (rVWF) Plus Tranexamic Acid vs. rVWF Alone to Reduce Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial | Von Willebrand Diseases;Postpartum Hemorrhage | Drug: Recombinant Von Willebrand factor;Drug: Tranexamic Acid Injection [Cyklokapron] | Margaret Ragni | NULL | Not yet recruiting | 18 Years | N/A | Female | 20 | Phase 3 | United States |
| 2 | NCT04146376 (ClinicalTrials.gov) | October 12, 2019 | 29/10/2019 | Von Willebrand Factor in Pregnancy (VIP) Study | Von Willebrand Factor in Pregnancy (VIP) Study: A Multicenter Study of Wilate Use in Von Willebrand Disease for Childbirth | Von Willebrand Diseases | Other: Use of a postpartum diary and additional blood draws;Drug: VWF replacement therapy with Wilate;Drug: Tranexamic acid;Other: Use of a postpartum diary and additional blood draws. | Bloodworks | Mary M. Gooley Hemophilia Center;Ergomed;Octapharma | Recruiting | 18 Years | N/A | Female | 110 | United States | |
| 3 | NCT02606045 (ClinicalTrials.gov) | February 7, 2019 | 5/11/2015 | Minimize Menorrhagia in Women With Von Willebrand Disease | Prospective, Randomized, Crossover Trial Comparing Recombinant Von Willebrand Factor (rVWF) vs. Tranexamic Acid (TA) to Minimize Menorrhagia in Women With Von Willebrand Disease: The VWD Minimize Study | Von Willebrand Diseases | Drug: recombinant von Willebrand factor;Drug: tranexamic acid | Margaret Ragni | University of North Carolina;Duke University | Recruiting | 13 Years | 45 Years | Female | 60 | Phase 3 | United States |
| 4 | NCT01800435 (ClinicalTrials.gov) | October 2011 | 15/2/2013 | A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor | Whole Blood Clot Stability and Thrombin Generating Capacity Following Treatment With Bypassing Agents (BPA) With and Without and Tranexamic Acid (TXA) in Haemophilia A Patients With inhibitor-an In-vivo Prospective Crossover Study | Hereditary Factor VIII Deficiency Disease With Inhibitor | Drug: aPCC, aPCC + TXA;Drug: rFVIIa, rFVIIa + TXA | Oslo University Hospital | NULL | Completed | 18 Years | 65 Years | Male | 6 | Phase 4 | Norway |
| 5 | NCT00111215 (ClinicalTrials.gov) | January 2001 | 18/5/2005 | Treatment and Management of Women With Bleeding Disorders | Treatment and Management of Women With Bleeding Disorders | Menorrhagia;Blood Coagulation Disorders;Blood Platelet Disorders;Von Willebrand Disease;Hematologic Disease | Drug: Tranexamic Acid;Drug: Desmopressin Acetate | Centers for Disease Control and Prevention | NULL | Completed | 18 Years | 50 Years | Female | 100 | N/A | United States |