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Probiotics    (DrugBank: -)

4 diseases
告示番号疾患名（ページ内リンク）臨床試験数
94原発性硬化性胆管炎1
96クローン病4
97潰瘍性大腸炎7
291ヒルシュスプルング病（全結腸型又は小腸型）4

94. 原発性硬化性胆管炎　［臨床試験数：134，薬物数：105（DrugBank：37），標的遺伝子数：18，標的パスウェイ数：131］
Searched query = "Primary sclerosing cholangitis", "PSC"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 134 trial found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT00161148
(ClinicalTrials.gov)		January 20058/9/2005Probiotics in Patients With Primary Sclerosing CholangitisProbiotics in Patients With Primary Sclerosing Cholangitis and Inflammatory Bowel Disease- a Randomized Placebo-Controlled Cross-Over TrialPrimary Sclerosing CholangitisDrug: ProbioticsUMC UtrechtNULLRecruiting18 YearsN/ABoth12Phase 3Netherlands

96. クローン病　［臨床試験数：2,209，薬物数：1,276（DrugBank：240），標的遺伝子数：166，標的パスウェイ数：210］
Searched query = "Crohn disease", "Terminal ileitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
4 / 2,209 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT01765998
(ClinicalTrials.gov)		February 20136/1/2013The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease)The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of InflammationCrohn's DiseaseDrug: Probiotic;Drug: PlaceboThe Baruch Padeh Medical Center, PoriyaNULLNot yet recruiting18 Years60 YearsBoth60Phase 4Israel
2NCT01078935
(ClinicalTrials.gov)		December 20121/3/2010The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of InflammationThe Effect of Probiotics on Bowel DiseaseCrohn's Disease;Ulcerative ColitisDietary Supplement: probiotics;Dietary Supplement: placeboThe Baruch Padeh Medical Center, PoriyaMinistry of Health, IsraelNot yet recruiting18 Years80 YearsBoth100Phase 4NULL
3NCT00587041
(ClinicalTrials.gov)		February 200621/12/2007Use of Oral Probiotics to Reduce Urinary Oxalate ExcretionUse of Oral Probiotics to Reduce Urinary Oxalate ExcretionNephrolithiasis;Hyperoxaluria;Crohn's DiseaseDietary Supplement: Oxadrop;Dietary Supplement: Agri-King Synbiotic (AKSB);Other: PlaceboMayo ClinicNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);National Institutes of Health (NIH);National Center for Complementary and Integrative Health (NCCIH);National Center for Research Resources (NCRR)Completed18 YearsN/AAll40Phase 1;Phase 2United States
4NCT00510978
(ClinicalTrials.gov)		January 20022/8/2007Probiotics in GastroIntestinal DisordersOne Year, Randomised, Double Blind, Placebo Controlled Trial of Probiotics, Bifidobacterium Infantis 35624 or Lactobacillus Salivarius UCC118, as Food Supplements for Maintenance of Remission in Crohn's Disease and Ulcerative ColitisUlcerative Colitis;Crohn's DiseaseBiological: Bifidobacterium infantis 35624;Biological: Lactobacillus salivarius UCC118;Biological: PlaceboUniversity College CorkEuropean CommissionActive, not recruitingN/A75 YearsBoth360Phase 2;Phase 3Ireland

97. 潰瘍性大腸炎　［臨床試験数：2,269，薬物数：1,331（DrugBank：241），標的遺伝子数：114，標的パスウェイ数：181］
Searched query = "Ulcerative colitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
7 / 2,269 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1ChiCTR2000032498
2020-09-012020-04-30Human experimental study on the effect of probiotics combined with prebiotics on ulcerative colitis: a randomized double-blind controlled trialHuman experimental study on the effect of probiotics combined with prebiotics on ulcerative colitis Ulcerative colitisExperimental group:Probiotics and prebiotics;placebo group:maltodextrin;Capital Medical UniversityNULLPendingBothExperimental group:15;placebo group:15;China
2NCT04006977
(ClinicalTrials.gov)		October 20191/7/2019Multistrain Probiotics Reduces UC Depression and Anxiety ScoresMultistrain Probiotic Product (De Simone Formulation) Reduces Depression and Anxiety Scores: a Randomized Pilot Study in Patients With Ulcerative ColitisUlcerative ColitisDietary Supplement: a multistrain probiotic product (DSF);Dietary Supplement: PlaceboXijing Hospital of Digestive DiseasesMENDES SANot yet recruiting18 Years65 YearsAll60N/AChina
3ChiCTR1900022243
2019-04-012019-03-31Effect of curcumin combined with probiotics on prevention and treatment in ileal pouchitis after operation of ulcerative colitis.Effect of curcumin combined with probiotics on prevention and treatment in ileal pouchitis after operation of ulcerative colitis. ileal pouchitis after operation of ulcerative colitisExperimental group:Curcumin+Probiotics;Control group:Probiotics;Tianjin Medical University General HospitalNULLRecruitingBothExperimental group:20;Control group:10;China
4ChiCTR-IPR-17010306
2017-02-012017-01-01Effects of probiotics on intestinal microecological reconstruction in patients with ulcerative colitisEffects of probiotics on intestinal microecological reconstruction in patients with ulcerative colitis Ulcerative colitisGroup A:Mesalazine combined with placebo; Group B:Methalazine combined with probiotics;Group C:Probiotics combined with placebo;Normal control group:Blank control;Affiliated Hospital of Inner Mongolia Medical UniversityNULLPending18BothGroup A:30; Group B:30;Group C:30;Normal control group:30;China
5NCT01078935
(ClinicalTrials.gov)		December 20121/3/2010The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation, Endothelial Function, and Markers of InflammationThe Effect of Probiotics on Bowel DiseaseCrohn's Disease;Ulcerative ColitisDietary Supplement: probiotics;Dietary Supplement: placeboThe Baruch Padeh Medical Center, PoriyaMinistry of Health, IsraelNot yet recruiting18 Years80 YearsBoth100Phase 4NULL
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
6NCT00578799
(ClinicalTrials.gov)		July 200818/12/2007Effects of Probiotics in Patients With Ulcerative ColitisEffects of Probiotics in Patients With Ulcerative Colitis.Ulcerative ColitisDietary Supplement: Kyo-Dophilus;Dietary Supplement: placeboUniversity of California, IrvineWakunaga Pharmaceutical Co., Ltd.Terminated18 Years65 YearsBoth40Phase 1United States
7NCT00510978
(ClinicalTrials.gov)		January 20022/8/2007Probiotics in GastroIntestinal DisordersOne Year, Randomised, Double Blind, Placebo Controlled Trial of Probiotics, Bifidobacterium Infantis 35624 or Lactobacillus Salivarius UCC118, as Food Supplements for Maintenance of Remission in Crohn's Disease and Ulcerative ColitisUlcerative Colitis;Crohn's DiseaseBiological: Bifidobacterium infantis 35624;Biological: Lactobacillus salivarius UCC118;Biological: PlaceboUniversity College CorkEuropean CommissionActive, not recruitingN/A75 YearsBoth360Phase 2;Phase 3Ireland

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291. ヒルシュスプルング病（全結腸型又は小腸型）　［臨床試験数：13，薬物数：32（DrugBank：15），標的遺伝子数：0，標的パスウェイ数：0］
Searched query = "Hirschsprung disease, entire colon type", "Hirschsprung disease, small intestine type", "Hirschsprung disease", "Hirschprung disease", "Hirschsprung disease associated entercolitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
4 / 13 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT02343562
(ClinicalTrials.gov)		October 20149/1/2015Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated EnterocolitisProbiotics for Prophylaxis of Postoperative Hirschsprungs Associated EnterocolitisHirschsprung DiseaseDietary Supplement: Probiotics;Dietary Supplement: PlaceboCairo UniversityNULLUnknown status6 Months12 YearsAll40Phase 4Egypt
2NCT02350088
(ClinicalTrials.gov)		January 201417/1/2015Fast-track Surgery in the Treatment of Hirschsprung's DiseaseFast-track Surgery in the Treatment of Hirschsprung's DiseaseSurgeryDrug: probiotics;Drug: placeboTongji HospitalChildren's Hospital BostonRecruiting1 Year18 YearsBoth100N/AChina
3NCT02234219
(ClinicalTrials.gov)		January 201427/8/2014Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled TrialComparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled TrialConstipationDrug: ProbioticsTongji HospitalNULLRecruitingN/A14 YearsAll50N/AChina
4NCT01934959
(ClinicalTrials.gov)		January 200821/8/2013A Trial on Probiotics in Preventing Hirschsprung's Disease Associated EntercolitisA Prospective Multicenter Randomized Controlled Trial on Probiotics in Preventing Hirschsprung's Disease Associated EntercolitisProbiotics;Hirschsprung's Disease Associated EnterocolitisDrug: BificoTongji HospitalAnhui Provincial HospitalCompleted1 Month13 YearsBoth60Phase 0NULL

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