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Serotonin    (DrugBank: Serotonin)

3 diseases
IDDisease name (Link within this page)Number of trials
2Amyotrophic lateral sclerosis2
96Crohn disease0
97Ulcerative colitis3

2. Amyotrophic lateral sclerosis    [ 508 clinical trials,   530 drugs,   (DrugBank: 146 drugs),   170 drug target genes,   221 drug target pathways]
Searched query = "Amyotrophic lateral sclerosis", "ALS"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 508 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT02851914
(ClinicalTrials.gov)		July 21, 201528/7/2016SSRIs vs. TCAs for Depression in ALS PatientsAn Open-Label Pilot Study Comparing the Efficacy of Selective Serotonin Re-Uptake Inhibitors (SSRIs) Versus Tricyclic Antidepressants (TCAs) for Treating Depression in Amyotrophic Lateral SclerosisDepression;Amyotrophic Lateral SclerosisDrug: Tricyclic Antidepressants (TCA);Drug: Selective Serotonin Uptake Inhibitors (SSRI)St. Louis UniversityNULLCompleted25 Years80 YearsAll2Early Phase 1United States
2NCT01160263
(ClinicalTrials.gov)		October 20129/7/2010Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and ControlsStudy of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls. Analysis With 123I-FP-CIT (Datscan) and 123I-ADAM Brain SPECTAmyotrophic Lateral SclerosisDrug: SPECT : 123 I-FP-CIT (DATSCAN) and 123I-ADAMAssistance Publique - Hôpitaux de ParisAssociation Française contre les Myopathies (AFM), Paris;ARS (Association pour la Recherche sur la Sclérose Latérale Amyotrophique);AGEPSCompleted39 Years66 YearsBoth16Phase 3France

96. Crohn disease    [ 2,209 clinical trials,   1,276 drugs,   (DrugBank: 240 drugs),   166 drug target genes,   210 drug target pathways]
Searched query = "Crohn disease", "Terminal ileitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: . Trials are sorted by Date_enrollment from most recent to oldest in the table.
0 / 2,209 trial found

97. Ulcerative colitis    [ 2,269 clinical trials,   1,331 drugs,   (DrugBank: 241 drugs),   114 drug target genes,   181 drug target pathways]
Searched query = "Ulcerative colitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
3 / 2,269 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1EUCTR2011-003532-32-LT
(EUCTR)		14/02/201228/11/2011A Pilot Study to Evaluate Safety and Efficacy of LX1606 in Subjects With Acute, Mild to Moderate Ulcerative ColitisPhase 2 Assessment of the Relationship between Serotonin and Efficacy in Ulcerative Colitis: A Multi-Center Randomized, Double Blind, Placebo-Controlled, Pilot Study to Evaluate Safety and Preliminary Efficacy of Orally Administered LX1606 in Subjects with Acute, Mild to Moderate Ulcerative Colitis Acute mild to moderate ulcerative colitis
MedDRA version: 14.1;Level: LLT;Classification code 10066678;Term: Acute ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]		Product Name: LX1606
Product Code: LX1606
INN or Proposed INN: Telotristat etiprate
Other descriptive name: telotristat etiprate		Lexicon Pharmaceuticals, Inc.NULLNot RecruitingFemale: yes
Male: yes		60Phase 2United States;Slovakia;Poland;Belgium;Lithuania
2NCT01456052
(ClinicalTrials.gov)		January 30, 201217/10/2011A Study to Evaluate Safety and Efficacy of Telotristat Etiprate (LX1606) in Participants With Acute, Mild to Moderate Ulcerative ColitisPhase 2 Assessment of the Relationship Between Serotonin and Efficacy in Ulcerative Colitis: A Multi-Center Randomized, Double Blind, Placebo-Controlled, Pilot Study to Evaluate Safety and Preliminary Efficacy of Orally Administered LX1606 in Subjects With Acute, Mild to Moderate Ulcerative ColitisUlcerative ColitisDrug: Telotristat Etiprate;Drug: PlaceboLexicon PharmaceuticalsNULLCompleted18 Years70 YearsAll59Phase 2United States;Lithuania;Poland;Slovakia
3EUCTR2011-003532-32-SK
(EUCTR)		19/12/201110/11/2011A Pilot Study to Evaluate Safety and Efficacy of LX1606 in Subjects With Acute, Mild to Moderate Ulcerative ColitisPhase 2 Assessment of the Relationship between Serotonin and Efficacy in Ulcerative Colitis: A Multi-Center Randomized, Double Blind, Placebo-Controlled, Pilot Study to Evaluate Safety and Preliminary Efficacy of Orally Administered LX1606 in Subjects with Acute, Mild to Moderate Ulcerative Colitis Acute mild to moderate ulcerative colitis
MedDRA version: 14.0;Level: LLT;Classification code 10066678;Term: Acute ulcerative colitis;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]		Product Name: LX1606
Product Code: LX1606
INN or Proposed INN: Non as of yet
Other descriptive name: telotristat etiprate		Lexicon Pharmaceuticals, Inc.NULLNot RecruitingFemale: yes
Male: yes		60Phase 2United States;Slovakia;Belgium;Poland;Lithuania

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