DDrare: Database of Drug Development for Rare Diseases

Diagnostic test: brain mri (DrugBank: -)

2 diseases

ID	Disease name (Link within this page)	Number of trials
25	Progressive multifocal leukoencephalopathy	1
229	Autoimmune pulmonary alveolar proteinosis	1

25. Progressive multifocal leukoencephalopathy [ 23 clinical trials, 33 drugs, (DrugBank: 20 drugs), 7 drug target genes, 36 drug target pathways]

Searched query = "Progressive multifocal leukoencephalopathy", "PML", "Leukoencephalopathy, progressive multifocal"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 23 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04453917 (ClinicalTrials.gov)	December 31, 2020	3/6/2020	Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy	Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy	Progressive Multifocal Leukoencephalopathy	Biological: Collection of blood and urine;Biological: Spinal tap;Diagnostic Test: Brain MRI;Biological: Neurological evaluation	University Hospital, Toulouse	NULL	Not yet recruiting	18 Years	N/A	All	15	N/A	France

229. Autoimmune pulmonary alveolar proteinosis [ 35 clinical trials, 30 drugs, (DrugBank: 8 drugs), 3 drug target genes, 12 drug target pathways]

Searched query = "Autoimmune pulmonary alveolar proteinosis", "Congenital pulmonary alveolar proteinosis", "Hereditary pulmonary alveolar proteinosis", "Pulmonary alveolar proteinosis", "PAP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 35 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03887169 (ClinicalTrials.gov)	September 16, 2019	12/3/2019	Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.	Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.	Pulmonary Alveolar Proteinosis;Mutation Ala393Thr of the MARS Gene;mutationSer567Leu of the MARS Gene	Drug: Methionine;Drug: Vitamin B12, B9, B6, C supplementation;Diagnostic Test: Methionine/homocysteine Dosage;Diagnostic Test: Thoracic CT scan;Diagnostic Test: Abdominal and liver ultrasound.;Diagnostic Test: Brain MRI	Assistance Publique - Hôpitaux de Paris	NULL	Completed	N/A	18 Years	All	3	Phase 1;Phase 2	France