Perhexiline (DrugBank: Perhexiline)
2 diseases| ID | Disease name (Link within this page) | Number of trials |
|---|---|---|
| 58 | Hypertrophic cardiomyopathy | 5 |
| 272 | Fibrodysplasia ossificans progressiva | 1 |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04426578 (ClinicalTrials.gov) | August 1, 2020 | 14/5/2020 | Role of Perhexiline in Hypertrophic Cardiomyopathy | Randomised Controlled Trial of pErhexiline on regreSsion Of Left Ventricular hypErtrophy (LVH) in Patients With Symptomatic Hypertrophic CardioMyopathy (RESOLVE-HCM) | Hypertrophic Cardiomyopathy | Drug: Perhexiline;Other: Placebo | Flinders University | NULL | Not yet recruiting | 18 Years | N/A | All | 60 | Phase 2 | NULL |
| 2 | NCT02862600 (ClinicalTrials.gov) | August 1, 2016 | 8/8/2016 | Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure | A Phase 2, Multi-Center, Open-Label, Ascending Dose Study on the Efficacy, Safety and Tolerability of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure With Preserved Left Ventricular Function | Cardiomyopathy, Hypertrophic;Cardiomyopathy, Hypertrophic, Familial | Drug: Perhexiline;Device: Use of bioanalytical assay to monitor plasma levels of perhexiline | Heart Metabolics Limited | NULL | Terminated | 18 Years | N/A | All | 35 | Phase 2 | United States |
| 3 | NCT02431221 (ClinicalTrials.gov) | July 22, 2015 | 27/4/2015 | Efficacy, Safety, and Tolerability of Perhexiline in Subjects With Hypertrophic Cardiomyopathy and Heart Failure | A Study on the Efficacy, Safety, and Tolerability of Perhexiline Maleate in Subjects With Hypertrophic Cardiomyopathy and Moderate-To-Severe Heart Failure | Hypertrophic Cardiomyopathy | Drug: Perhexiline;Drug: Placebo | Heart Metabolics Limited | NULL | Withdrawn | 18 Years | N/A | All | 0 | Phase 3 | NULL |
| 4 | NCT00500552 (ClinicalTrials.gov) | December 2006 | 10/7/2007 | Perhexiline Therapy in Patients With Hypertrophic Cardiomyopathy | Metabolic Alteration With Perhexiline Therapy in Patients With Hypertrophic Cardiomyopathy (METAL-HCM Study) | Hypertrophic Cardiomyopathy | Drug: Perhexiline/Placebo | University Hospital Birmingham | British Heart Foundation;University College London Hospitals;University of Oxford | Completed | 18 Years | 80 Years | Both | 44 | Phase 2 | United Kingdom |
| 5 | EUCTR2005-000755-15-GB (EUCTR) | 25/10/2005 | 27/05/2005 | Perhexiline therapy in patients with Hypertrophic Cardiomyopathy | Perhexiline therapy in patients with Hypertrophic Cardiomyopathy | Hypertrophic Cardiomyopathy | Product Name: Pexsig INN or Proposed INN: Perxexiline | University Hospital of Birmingham Foundation Trust | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 50 | United Kingdom |
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | JPRN-UMIN000019348 | 2010/07/01 | 14/10/2015 | Approved calcium channel blocker in the treatment of fibrodysplasia ossificans progressiva (FOP) | fibrodysplasia ossificans progressiva | oral administration of perhexiline maleate for one year | Nagoya University Graduate School of Medicine | NULL | Complete: follow-up complete | 15years-old | 65years-old | Male and Female | 5 | Phase 1;Phase 2 | Japan |