DDrare: Database of Drug Development for Rare Diseases

Questran (DrugBank: -)

3 diseases

ID	Disease name (Link within this page)	Number of trials
93	Primary biliary cholangitis [Primary biliary cirrhosis (~Mar 2017)]	1
254	Porphyria	1
297	Alagille syndrome	1

93. Primary biliary cholangitis [Primary biliary cirrhosis (~Mar 2017)] [ 230 clinical trials, 215 drugs, (DrugBank: 51 drugs), 34 drug target genes, 107 drug target pathways]

Searched query = "Primary biliary cholangitis", "Primary biliary cirrhosis", "PBC"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 230 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02963077 (ClinicalTrials.gov)	July 2013	1/11/2016	A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384	A Phase I, Double-Blind Single and Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of A4250 as Monotherapy, and in Combination With Colonic Release Cholestyramine (A3384) or Commercially Available Cholestyramine (Questran™) in Healthy Subjects	Orphan Cholestatic Liver Diseases;Primary Biliary Cirrhosis;Progressive Familial Intrahepatic Cholestasis;Alagille Syndrome	Drug: A4250;Drug: CRC (A3384);Drug: Questran;Drug: Placebo	Albireo	NULL	Completed	18 Years	60 Years	Both	94	Phase 1	NULL

254. Porphyria [ 59 clinical trials, 52 drugs, (DrugBank: 17 drugs), 17 drug target genes, 33 drug target pathways]

Searched query = "Porphyria", "CEP", "Erythropoietic protoporphyria", "EPP", "X-linked dominant protoporphyria", "XLDP", "PCT", "HEP", "AIP", "ADP", "VP", "Hereditary coproporphyria", "HCP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 59 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2007-002863-28-GB (EUCTR)	26/09/2007	15/08/2007	Investigation into the use of colestyramine as a therapy for patients with erythropoietic protoporphyria - EPP001	Investigation into the use of colestyramine as a therapy for patients with erythropoietic protoporphyria - EPP001	Erythropoietic protoporphyria (EPP) MedDRA version: 9.1;Level: LLT;Classification code 10015289;Term: Erythropoietic protoporphyria	Trade Name: Questran Product Name: Questran INN or Proposed INN: COLESTYRAMINE	Guy's & St Thomas' NHS Foundation Trust	NULL	Not Recruiting			Female: yes Male: yes	21	Phase 4	United Kingdom

297. Alagille syndrome [ 26 clinical trials, 16 drugs, (DrugBank: 8 drugs), 2 drug target genes, 2 drug target pathways]

Searched query = "Alagille syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

1 / 26 trial found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02963077 (ClinicalTrials.gov)	July 2013	1/11/2016	A Safety and Pharmakokinetic Study of A4250 Alone or in Combination With A3384	A Phase I, Double-Blind Single and Multiple Ascending Dose Study to Assess Safety and Pharmacokinetics of A4250 as Monotherapy, and in Combination With Colonic Release Cholestyramine (A3384) or Commercially Available Cholestyramine (Questran™) in Healthy Subjects	Orphan Cholestatic Liver Diseases;Primary Biliary Cirrhosis;Progressive Familial Intrahepatic Cholestasis;Alagille Syndrome	Drug: A4250;Drug: CRC (A3384);Drug: Questran;Drug: Placebo	Albireo	NULL	Completed	18 Years	60 Years	Both	94	Phase 1	NULL