Amg 181    (DrugBank: -)

2 diseases
IDDisease name (Link within this page)Number of trials
96Crohn disease10
97Ulcerative colitis16

96. Crohn disease    [ 2,209 clinical trials,   1,276 drugs,   (DrugBank: 240 drugs),   166 drug target genes,   210 drug target pathways]
Searched query = "Crohn disease", "Terminal ileitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
10 / 2,209 trials found
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1EUCTR2012-000529-31-NL
(EUCTR)
07/01/201322/01/2013A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 16.1;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2United States;France;Hungary;Czech Republic;Canada;Belgium;Denmark;Austria;Germany;Netherlands;United Kingdom
2EUCTR2012-000529-31-DE
(EUCTR)
17/12/201201/10/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 20.0;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000016693;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2France;United States;Hungary;Czech Republic;Canada;Belgium;Denmark;Austria;Netherlands;Germany;United Kingdom
3NCT01696396
(ClinicalTrials.gov)
December 4, 201227/9/2012Abrilumab (AMG 181) in Adults With Moderate to Severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects With Moderate to Severe Crohn's DiseaseCrohn's DiseaseDrug: Abrilumab;Drug: PlaceboAmgenNULLCompleted18 Years65 YearsAll254Phase 2United States;Austria;Belgium;Canada;Czechia;Denmark;France;Germany;Hungary;Netherlands;Switzerland;United Kingdom;Czech Republic
4EUCTR2012-000529-31-HU
(EUCTR)
13/11/201204/10/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 16.0;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2France;United States;Czech Republic;Hungary;Canada;Belgium;Denmark;Austria;Netherlands;Germany;United Kingdom
5EUCTR2012-000529-31-BE
(EUCTR)
09/11/201219/09/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 17.1;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2France;United States;Hungary;Czech Republic;Canada;Belgium;Denmark;Austria;Netherlands;Germany;United Kingdom
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
6EUCTR2012-000529-31-CZ
(EUCTR)
18/10/201221/09/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 16.1;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2United States;France;Hungary;Czech Republic;Canada;Belgium;Denmark;Austria;Germany;Netherlands;United Kingdom
7EUCTR2012-000529-31-DK
(EUCTR)
10/10/201226/09/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 19.0;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2France;United States;Hungary;Czech Republic;Canada;Belgium;Austria;Denmark;Netherlands;Germany;United Kingdom
8EUCTR2012-000529-31-AT
(EUCTR)
09/10/201203/10/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 20.0;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
252Phase 2France;United States;Hungary;Czech Republic;Canada;Belgium;Denmark;Austria;Netherlands;Germany;United Kingdom
9EUCTR2012-000529-31-GB
(EUCTR)
27/09/201221/09/2012A study to find out more about the effect of AMG 181 in people with moderate to severe Crohn's DiseaseA Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Crohn’s Disease Moderate to severe Crohn's Disease
MedDRA version: 17.0;Level: LLT;Classification code 10011402;Term: Crohn's disease (colon);System Organ Class: 100000004856 ;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Amgen IncNULLNot Recruiting Female: yes
Male: yes
252Phase 2France;United States;Hungary;Czech Republic;Canada;Belgium;Denmark;Austria;Netherlands;Germany;United Kingdom
10NCT01290042
(ClinicalTrials.gov)
February 201127/1/2011Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.A Phase 1, Randomized, Double-Blind, Placebo-controlled, Ascending Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects, in Subjects With Active Ulcerative Colitis, and in Subjects With Active Crohn's Disease.Ulcerative Colitis;Crohn's DiseaseDrug: AMG 181;Other: Placebo for AMG 181AmgenNULLCompleted18 Years65 YearsBoth43Phase 1United States;Australia

97. Ulcerative colitis    [ 2,269 clinical trials,   1,331 drugs,   (DrugBank: 241 drugs),   114 drug target genes,   181 drug target pathways]
Searched query = "Ulcerative colitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
16 / 2,269 trials found
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1EUCTR2011-005251-13-EE
(EUCTR)
31/03/201415/01/2014A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 16.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
360United States;Estonia;Greece;Austria;Russian Federation;United Kingdom;Italy;Switzerland;France;Hungary;Czech Republic;Canada;Poland;Belgium;Denmark;Australia;Latvia;Netherlands;Norway;Germany;New Zealand
2EUCTR2011-005251-13-LV
(EUCTR)
03/03/201416/01/2014A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 16.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Russian Federation;United Kingdom;Italy;Switzerland;France;Hungary;Czech Republic;Canada;Poland;Belgium;Denmark;Australia;Latvia;Netherlands;Norway;Germany;New Zealand
3EUCTR2011-005251-13-PL
(EUCTR)
23/04/201310/01/2013A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 20.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Hungary;Czech Republic;Canada;Poland;Belgium;Australia;Denmark;Latvia;Norway;Netherlands;Germany
4EUCTR2011-005251-13-NL
(EUCTR)
08/01/201323/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 16.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
315Phase 2United States;Estonia;Greece;Austria;United Kingdom;Switzerland;Italy;France;Czech Republic;Hungary;Canada;Poland;Belgium;Australia;Denmark;Latvia;Norway;Netherlands;Germany
5EUCTR2011-005251-13-DE
(EUCTR)
21/12/201209/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 20.0;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Czech Republic;Hungary;Canada;Poland;Belgium;Australia;Denmark;Norway;Netherlands;Latvia;Germany
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
6NCT01694485
(ClinicalTrials.gov)
November 16, 201224/9/2012Abrilumab (AMG 181) in Adults With Moderate to Severe Ulcerative ColitisA Randomized, Double Blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects With Moderate to Severe Ulcerative ColitisUlcerative ColitisBiological: Abrilumab;Drug: PlaceboAmgenNULLCompleted18 Years65 YearsAll359Phase 2United States;Australia;Austria;Belgium;Canada;Czechia;Denmark;Estonia;France;Germany;Greece;Hungary;Italy;Latvia;Netherlands;Norway;Poland;Russian Federation;Switzerland;United Kingdom;Czech Republic
7EUCTR2011-005251-13-IT
(EUCTR)
16/09/201227/08/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 14.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG181
Product Code: AMG181
AMGEN INC.NULLNot RecruitingFemale: yes
Male: yes
315Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;Czech Republic;Hungary;Canada;Denmark;Latvia;Germany;Netherlands;Poland;Belgium;Australia
8EUCTR2011-005251-13-BE
(EUCTR)
14/09/201218/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 14.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Hungary;Czech Republic;Canada;Belgium;Poland;Australia;Denmark;Latvia;Germany;Netherlands;Norway
9EUCTR2011-005251-13-HU
(EUCTR)
11/09/201218/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 14.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Hungary;Czech Republic;Canada;Poland;Belgium;Australia;Denmark;Latvia;Netherlands;Germany;Norway
10EUCTR2011-005251-13-AT
(EUCTR)
10/09/201223/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 18.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Czech Republic;Hungary;Canada;Poland;Belgium;Australia;Denmark;Latvia;Norway;Netherlands;Germany
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
11EUCTR2011-005251-13-GB
(EUCTR)
06/09/201213/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 17.0;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856 ;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Amgen IncNULLNot Recruiting Female: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;United Kingdom;Switzerland;France;Czech Republic;Hungary;Canada;Poland;Belgium;Australia;Denmark;Latvia;Norway;Netherlands;Germany
12EUCTR2011-005251-13-DK
(EUCTR)
16/08/201211/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 19.0;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Czech Republic;Hungary;Canada;Poland;Belgium;Denmark;Australia;Latvia;Norway;Netherlands;Germany
13EUCTR2011-005251-13-CZ
(EUCTR)
26/07/201217/07/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 16.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
360Phase 2United States;Estonia;Greece;Austria;United Kingdom;Italy;Switzerland;France;Hungary;Czech Republic;Canada;Poland;Belgium;Australia;Denmark;Latvia;Netherlands;Norway;Germany
14EUCTR2011-005251-13-GR
(EUCTR)
05/06/201214/05/2012A study to find out more about the effect of AMG 181 in people with moderate to severe ulcerative colitisA Randomized, Double blind, Multiple Dose Placebo Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 181 in Subjects with Moderate to Severe Ulcerative Colitis Moderate to severe Ulcerative Colitis
MedDRA version: 14.1;Level: LLT;Classification code 10045365;Term: Ulcerative colitis;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: AMG 181
Product Code: AMG 181
INN or Proposed INN: AMG 181
Amgen IncNULLNot RecruitingFemale: yes
Male: yes
315Phase 2United States;Estonia;Greece;Austria;Italy;Switzerland;United Kingdom;France;Hungary;Czech Republic;Canada;Poland;Belgium;Australia;Denmark;Netherlands;Latvia;Germany;Norway
15NCT01290042
(ClinicalTrials.gov)
February 201127/1/2011Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.A Phase 1, Randomized, Double-Blind, Placebo-controlled, Ascending Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects, in Subjects With Active Ulcerative Colitis, and in Subjects With Active Crohn's Disease.Ulcerative Colitis;Crohn's DiseaseDrug: AMG 181;Other: Placebo for AMG 181AmgenNULLCompleted18 Years65 YearsBoth43Phase 1United States;Australia
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
16NCT01164904
(ClinicalTrials.gov)
July 20101/7/2010Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative ColitisA Phase 1, Randomized, Double-blind, Placebo-controlled, Ascending Single Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181 in Healthy Subjects and Subjects With Mild to Moderate Ulcerative ColitisUlcerative ColitisDrug: Amg 181AmgenNULLTerminated18 Years55 YearsBoth72Phase 1United States;Australia;New Zealand