Target Gene/Pathway Pathway / Gene


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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CFTR 3件: Tight junction, Pancreatic secretion, Vibrio cholerae infection D09916 Ivacaftor 1件: 299
2 CFTR 3件: Tight junction, Pancreatic secretion, Vibrio cholerae infection D10134 Lumacaftor 1件: 299
3 CFTR 3件: Tight junction, Pancreatic secretion, Vibrio cholerae infection D11041 Tezacaftor 1件: 299
4 CFTR 3件: Tight junction, Pancreatic secretion, Vibrio cholerae infection D11423 Deutivacaftor 1件: 299
5 CFTR 3件: Tight junction, Pancreatic secretion, Vibrio cholerae infection D11507 Elexacaftor 1件: 299
6 CFTR 3件: Tight junction, Pancreatic secretion, Vibrio cholerae infection D11724 Galicaftor 1件: 299
7 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00113 Atropine 2件: 2, 299
8 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00138 Scopolamine 1件: 2
9 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00270 Chlorpromazine 1件: 254
10 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00397 Tropicamide 3件: 6, 13, 19
11 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00465 Oxybutynin 3件: 6, 13, 53
12 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00481 Propantheline 1件: 26
13 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00525 Pilocarpine 3件: 6, 53, 299
14 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00646 Tolterodine 2件: 17, 53
15 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00661 Cevimeline 1件: 53
16 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00722 Oxybutynin 3件: 6, 13, 53
17 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00765 Rocuronium 1件: 296
18 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00787 Trihexyphenidyl 2件: 5, 6
19 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D00789 Chlorpromazine 1件: 254
20 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01000 Bethanechol 1件: 98
21 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01077 Atropine 2件: 2, 299
22 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01148 Tolterodine 2件: 17, 53
23 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01269 Solifenacin 3件: 6, 13, 53
24 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D01699 Darifenacin 2件: 6, 13
25 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D02069 Atropine 2件: 2, 299
26 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D02200 Pilocarpine 3件: 6, 53, 299
27 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D02212 Ipratropium 2件: 6, 86
28 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03011 Atropine 2件: 2, 299
29 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03274 Chlorpromazine 1件: 254
30 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03654 Darifenacin 2件: 6, 13
31 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D03814 Atropine 2件: 2, 299
32 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D04034 Chlorpromazine 1件: 254
33 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D05478 Pilocarpine 3件: 6, 53, 299
34 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07226 Fesoterodine 1件: 6
35 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D07667 Cevimeline 1件: 53
36 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08441 Propiverine 1件: 226
37 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08522 Solifenacin 3件: 6, 13, 53
38 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D08638 Trihexyphenidyl 2件: 5, 6
39 CHRM3 5件: Taste transduction, Regulation of actin cytoskeleton, Salivary secretion, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases D11383 Blarcamesine 1件: 156
40 AMY2A 3件: Starch and sucrose metabolism, Salivary secretion, Pancreatic secretion D00216 Acarbose 1件: 298
41 AMY2B 3件: Starch and sucrose metabolism, Salivary secretion, Pancreatic secretion D00216 Acarbose 1件: 298
42 KCNQ1 3件: Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D00636 Amiodarone 2件: 28, 127
43 KCNQ1 3件: Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D02910 Amiodarone 2件: 28, 127
44 KCNQ1 3件: Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection D09569 Ezogabine 2件: 2, 144
45 ATP1A1 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00297 Digitoxin 1件: 299
46 ATP1A1 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00298 Digoxin 3件: 8, 46, 210
47 ATP1A2 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00297 Digitoxin 1件: 299
48 ATP1A2 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00298 Digoxin 3件: 8, 46, 210
49 ATP1A3 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00297 Digitoxin 1件: 299
50 ATP1A3 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00298 Digoxin 3件: 8, 46, 210
51 ATP1A4 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00297 Digitoxin 1件: 299
52 ATP1A4 6件: Thyroid hormone synthesis, Thyroid hormone signaling pathway, Proximal tubule bicarbonate reclamation, Salivary secretion, Pancreatic secretion, Protein digestion and absorption D00298 Digoxin 3件: 8, 46, 210
53 SLC12A2 3件: Salivary secretion, Pancreatic secretion, Vibrio cholerae infection D00247 Bumetanide 2件: 6, 158
54 SLC12A2 3件: Salivary secretion, Pancreatic secretion, Vibrio cholerae infection D00331 Furosemide 1件: 6
55 CA2 2件: Proximal tubule bicarbonate reclamation, Pancreatic secretion D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
56 CA2 2件: Proximal tubule bicarbonate reclamation, Pancreatic secretion D00518 Diclofenamide 1件: 114
57 CA2 2件: Proximal tubule bicarbonate reclamation, Pancreatic secretion D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
58 CA2 2件: Proximal tubule bicarbonate reclamation, Pancreatic secretion D00653 Dorzolamide 1件: 90
59 CA2 2件: Proximal tubule bicarbonate reclamation, Pancreatic secretion D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
60 CA2 2件: Proximal tubule bicarbonate reclamation, Pancreatic secretion D07871 Dorzolamide 1件: 90
61 CD38 2件: Salivary secretion, Pancreatic secretion D10777 Daratumumab 5件: 16, 28, 49, 63, 222
62 CD38 2件: Salivary secretion, Pancreatic secretion D11050 Isatuximab 2件: 28, 61
63 CD38 2件: Salivary secretion, Pancreatic secretion D11945 Mezagitamab 1件: 66