Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 MTOR 5件: Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
2 MTOR 5件: Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia D02714 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
3 MTOR 5件: Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia D06068 Temsirolimus 4件: 13, 34, 89, 331
4 GRIA1 1件: Spinocerebellar ataxia D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
5 GRIA1 1件: Spinocerebellar ataxia D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
6 GRIA1 1件: Spinocerebellar ataxia D02696 Talampanel 2件: 2, 6
7 GRIA1 1件: Spinocerebellar ataxia D08964 Perampanel 3件: 2, 6, 144
8 GRIA2 1件: Spinocerebellar ataxia D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
9 GRIA2 1件: Spinocerebellar ataxia D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
10 GRIA2 1件: Spinocerebellar ataxia D02696 Talampanel 2件: 2, 6
11 GRIA2 1件: Spinocerebellar ataxia D08964 Perampanel 3件: 2, 6, 144
12 GRIA3 2件: Spinocerebellar ataxia, Transcriptional misregulation in cancer D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
13 GRIA3 2件: Spinocerebellar ataxia, Transcriptional misregulation in cancer D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
14 GRIA3 2件: Spinocerebellar ataxia, Transcriptional misregulation in cancer D02696 Talampanel 2件: 2, 6
15 GRIA3 2件: Spinocerebellar ataxia, Transcriptional misregulation in cancer D08964 Perampanel 3件: 2, 6, 144
16 GRIN1 1件: Spinocerebellar ataxia D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
17 GRIN1 1件: Spinocerebellar ataxia D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
18 GRIN1 1件: Spinocerebellar ataxia D00777 Amantadine 4件: 6, 8, 13, 127
19 GRIN1 1件: Spinocerebellar ataxia D00848 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
20 GRIN1 1件: Spinocerebellar ataxia D02780 Acamprosate 2件: 6, 206
21 GRIN1 1件: Spinocerebellar ataxia D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
22 GRIN1 1件: Spinocerebellar ataxia D03744 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
23 GRIN1 1件: Spinocerebellar ataxia D04905 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
24 GRIN1 1件: Spinocerebellar ataxia D07058 Acamprosate 2件: 6, 206
25 GRIN1 1件: Spinocerebellar ataxia D07283 Esketamine 3件: 2, 4, 70
26 GRIN1 1件: Spinocerebellar ataxia D07441 Amantadine 4件: 6, 8, 13, 127
27 GRIN1 1件: Spinocerebellar ataxia D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
28 GRIN1 1件: Spinocerebellar ataxia D08174 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
29 GRIN1 1件: Spinocerebellar ataxia D09917 Latrepirdine 1件: 8
30 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
31 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
32 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00777 Amantadine 4件: 6, 8, 13, 127
33 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00848 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
34 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D02780 Acamprosate 2件: 6, 206
35 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
36 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D03744 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
37 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D04905 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
38 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate 2件: 6, 206
39 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine 3件: 2, 4, 70
40 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine 4件: 6, 8, 13, 127
41 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
42 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
43 GRIN2A 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine 1件: 8
44 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
45 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
46 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00777 Amantadine 4件: 6, 8, 13, 127
47 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D00848 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
48 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D02780 Acamprosate 2件: 6, 206
49 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
50 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D03744 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
51 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D04905 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
52 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D07058 Acamprosate 2件: 6, 206
53 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D07283 Esketamine 3件: 2, 4, 70
54 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D07441 Amantadine 4件: 6, 8, 13, 127
55 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
56 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D08174 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
57 GRIN2B 2件: Spinocerebellar ataxia, Systemic lupus erythematosus D09917 Latrepirdine 1件: 8
58 GRIN2C 1件: Spinocerebellar ataxia D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
59 GRIN2C 1件: Spinocerebellar ataxia D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
60 GRIN2C 1件: Spinocerebellar ataxia D00777 Amantadine 4件: 6, 8, 13, 127
61 GRIN2C 1件: Spinocerebellar ataxia D00848 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
62 GRIN2C 1件: Spinocerebellar ataxia D02780 Acamprosate 2件: 6, 206
63 GRIN2C 1件: Spinocerebellar ataxia D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
64 GRIN2C 1件: Spinocerebellar ataxia D03744 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
65 GRIN2C 1件: Spinocerebellar ataxia D04905 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
66 GRIN2C 1件: Spinocerebellar ataxia D07058 Acamprosate 2件: 6, 206
67 GRIN2C 1件: Spinocerebellar ataxia D07283 Esketamine 3件: 2, 4, 70
68 GRIN2C 1件: Spinocerebellar ataxia D07441 Amantadine 4件: 6, 8, 13, 127
69 GRIN2C 1件: Spinocerebellar ataxia D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
70 GRIN2C 1件: Spinocerebellar ataxia D08174 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
71 GRIN2C 1件: Spinocerebellar ataxia D09917 Latrepirdine 1件: 8
72 GRIN2D 1件: Spinocerebellar ataxia D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
73 GRIN2D 1件: Spinocerebellar ataxia D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
74 GRIN2D 1件: Spinocerebellar ataxia D00777 Amantadine 4件: 6, 8, 13, 127
75 GRIN2D 1件: Spinocerebellar ataxia D00848 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
76 GRIN2D 1件: Spinocerebellar ataxia D02780 Acamprosate 2件: 6, 206
77 GRIN2D 1件: Spinocerebellar ataxia D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
78 GRIN2D 1件: Spinocerebellar ataxia D03744 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
79 GRIN2D 1件: Spinocerebellar ataxia D04905 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
80 GRIN2D 1件: Spinocerebellar ataxia D07058 Acamprosate 2件: 6, 206
81 GRIN2D 1件: Spinocerebellar ataxia D07283 Esketamine 3件: 2, 4, 70
82 GRIN2D 1件: Spinocerebellar ataxia D07441 Amantadine 4件: 6, 8, 13, 127
83 GRIN2D 1件: Spinocerebellar ataxia D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
84 GRIN2D 1件: Spinocerebellar ataxia D08174 Memantine 7件: 2, 6, 8, 13, 49, 127, 205
85 GRIN2D 1件: Spinocerebellar ataxia D09917 Latrepirdine 1件: 8
86 KCNC3 1件: Spinocerebellar ataxia D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
87 KCNC3 1件: Spinocerebellar ataxia D10228 Amifampridine 3件: 3, 11, 12
88 KCND3 1件: Spinocerebellar ataxia D00636 Amiodarone 2件: 28, 127
89 KCND3 1件: Spinocerebellar ataxia D02910 Amiodarone 2件: 28, 127
90 KCND3 1件: Spinocerebellar ataxia D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
91 KCND3 1件: Spinocerebellar ataxia D10228 Amifampridine 3件: 3, 11, 12
92 MAP3K5 4件: Tight junction, TNF signaling pathway, Thermogenesis, Spinocerebellar ataxia D10988 Selonsertib 1件: 86
93 PIK3CA 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
94 PIK3CB 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
95 PIK3CD 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib 2件: 53, 65
96 PIK3CD 9件: VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib 3件: 35, 53, 61
97 PSMB5 1件: Spinocerebellar ataxia D03150 Bortezomib 16件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331
98 PSMB5 1件: Spinocerebellar ataxia D08880 Carfilzomib 1件: 28
99 PSMB5 1件: Spinocerebellar ataxia D10130 Ixazomib 5件: 13, 16, 28, 51, 61