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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
112-Lead ECG----[2] 140, 144
2Any other approved Antiepileptic Drug----[1] 144
3Cannabidiol[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[18] 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
4Cannabidiol (CBD)[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[7] 6, 13, 140, 144, 145, 156, 158
5Cannabidiol Oral Solution[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[4] 140, 144, 145, 193
6Carisbamate[1] Carisbamate[1] D06573 --[1] 144
7CBD----[12] 2, 6, 8, 13, 36, 46, 140, 144, 145, 156, 158, 206
8CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[2] 140, 144
9Clobazam[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 140, 144
10Clobazam High Dose[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
11Clobazam Low Dose[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
12Clobazam Medium Dose[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
13Clobazam PhEur[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
14Clobazam Tablets[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
15Clobazam Tablets 10mg[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
16Clobazam Tablets 20mg[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
17Clobazam Tablets 5mg[1] Clobazam[1] D01253 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 144
18E2007----[2] 6, 144
19E2080----[1] 144
20Ezogabine[1] Ezogabine[1] D09569 [5] KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		[6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬[2] 2, 144
21EZOGABINE (US ONLY)[1] Ezogabine[1] D09569 [5] KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		[6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬[1] 144
22Ezogabine/retigabine[1] Ezogabine[1] D09569 [5] KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		[6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬[1] 144
23Fenfluramina[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[2] 140, 144
24Fenfluramina Cloridrato[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[2] 140, 144
25FENFLURAMINE[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[4] 140, 144, 145, 149
26Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[1] 144
27FENFLURAMINE HYDROCHLORIDE[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[2] 140, 144
28FENFLURAMINE HYDROCHLORIDE (colorless)[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[2] 140, 144
29Fycompa[1] Perampanel[1] D08964 [4] GRIA1,
GRIA2,
GRIA3,
GRIA4 💬		[16] Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[2] 2, 144
30GW582892----[1] 144
31GWP42003-P----[5] 140, 144, 145, 156, 158
32GWP42003-P 20 mg/kg/day Dose----[2] 140, 144
33Inovelon[1] Rufinamide[1] D05775 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 144
34Investigators Choice of Approved AED----[1] 144
35Investigators choice of approved AEDs----[1] 144
36Lamictal[1] Lamotrigine[1] D00354 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 144
37Lamotrigine[1] Lamotrigine[1] D00354 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[5] 13, 34, 38, 114, 144
38Melatonin[1] Melatonin[1] D08170 [2] MTNR1A,
MTNR1B 💬		[2] Circadian entrainment, Neuroactive ligand-receptor interaction 💬[12] 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
39PEG----[12] 6, 13, 41, 46, 65, 78, 96, 97, 140, 144, 240, 299
40Perampanel[1] Perampanel[1] D08964 [4] GRIA1,
GRIA2,
GRIA3,
GRIA4 💬		[16] Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[3] 2, 6, 144
41Placebo----[27] 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
42Potiga[1] Ezogabine[1] D09569 [5] KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		[6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬[1] 144
43RETIGABINE[1] Ezogabine[1] D09569 [5] KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		[6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬[2] 2, 144
44RETIGABINE/EZOGABINE[1] Ezogabine[1] D09569 [5] KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		[6] Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬[1] 144
45RUFINAMIDE[1] Rufinamide[1] D05775 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 144
46Rufinamide (E2080)[1] Rufinamide[1] D05775 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 144
47Rufinamide oral suspension[1] Rufinamide[1] D05775 [5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 144
48Sodio valproato----[1] 144
49SOTICLESTAT----[2] 140, 144
50TAK-935----[2] 140, 144
51Topimarate----[1] 144
52Topimarato----[1] 144
53TOPIRAMATE[1] Topiramate[1] D00537 [36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 97, 140, 144, 156, 193
54Turmeric[1] Turmeric---[4] 140, 144, 158, 299
55ZX008----[2] 140, 144
56ZX008 (Fenfluramine Hydrochloride)[1] Fenfluramine[1] D07945 [4] HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬		[6] Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬[2] 140, 144
57ZX008 0.2 or 0.8 mg/kg/day----[1] 144
58ZX008 0.2 to 0.8 mg/kg/day----[2] 140, 144