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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
11.2 mg ZGN-440 for injectable suspension----[1] 193
21.8 mg ZGN-440 for injectable suspension----[1] 193
33.2 mg intranasal carbetocin[1] Carbetocin[1] D07229 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
49.6 mg intranasal carbetocin[1] Carbetocin[1] D07229 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
5Acetylcysteine[1] Acetylcysteine[1] D00221 --[20] 6, 13, 19, 20, 34, 49, 51, 53, 58, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
6Acomplia[1] Rimonabant[1] D05731 [1] CNR1 💬[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[1] 193
7ACOMPLIA 20 mg film-coated tablets[1] Rimonabant[1] D05731 [1] CNR1 💬[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[1] 193
8ACTH[1] Corticotropin[1] D00146 [1] MC2R 💬[5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[5] 13, 66, 145, 193, 222
9Acylated and unacylated ghrelin dosages[1] Lenomorelin---[3] 193, 201, 202
10Air----[8] 3, 13, 51, 58, 85, 97, 193, 299
11ANASTROZOLE[1] Anastrozole[1] D00960 [1] CYP19A1 💬[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬[3] 78, 86, 193
12ARD-101----[1] 193
13AZP-531----[1] 193
14B. lactis B94----[1] 193
15Beloranib[1] Beloranib---[1] 193
16Biopsy----[4] 19, 51, 78, 193
17Byetta[1] Exenatide[1] D04121 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[3] 6, 78, 193
18Cannabidiol[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[18] 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
19Cannabidiol Oral Solution[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[4] 140, 144, 145, 193
20Carbetocin[1] Carbetocin[1] D07229 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
21CBDV[1] Cannabidivarin---[1] 193
22CBDV Compound[1] Cannabidivarin---[1] 193
23Chloride[1] Chloride ion---[29] 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 271, 288, 296, 297, 299, 338
24Choline[1] Choline[1] D07690 --[4] 93, 171, 193, 299
25Coenzyme Q10[1] Ubidecarenone[1] D01065 --[12] 2, 5, 6, 8, 10, 18, 46, 57, 113, 193, 214, 215
26D.3.2 Product code where applicable13:----[1] 193
27DCCR----[1] 193
28DEXA, blood tests, H.G.P.O, osseous age.----[2] 78, 193
29Diazoxide[1] Diazoxide[1] D00294 [2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[2] 13, 193
30DIAZOXIDE CHOLINE[2] Choline,
Diazoxide		[2] D00294 ,
D07690 		[2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[1] 193
31Diazoxide choline controlled-release tablet[2] Choline,
Diazoxide		[2] D00294 ,
D07690 		[2] ABCC8,
KCNJ11 💬		[4] ABC transporters, GnRH secretion, Insulin secretion, Type II diabetes mellitus 💬[1] 193
32EU/1/06/362/003: 5µg (1 pen)----[1] 193
33Eutropin----[2] 78, 193
34EXENATIDE[1] Exenatide[1] D04121 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[6] 6, 17, 72, 78, 193, 233
35FE 992097----[1] 193
36Fluimucil----[4] 85, 94, 193, 298
37Fluimucil (acetylcysteine)[1] Acetylcysteine[1] D00221 --[1] 193
38Follow-up probiotic----[1] 193
39Follow-up study of the treated cohort----[1] 193
40GENOTONORM----[1] 193
41Genotonorm Miniquick 0,2 mg----[1] 193
42Genotropin----[5] 13, 78, 107, 187, 193
43GENOTROPIN (Somatropin) is a growth hormone treatment. It is an exact copy of the natural growth hormone that our bodies make. The main difference is that GENOTROPIN is man-made.[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
44Ghrelin[1] Lenomorelin---[6] 6, 78, 193, 201, 202, 299
45GLWL-01----[1] 193
46Gold[1] Gold---[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 171, 193, 218, 222, 224, 227, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318
47Growth hormone[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[13] 2, 13, 19, 46, 78, 96, 107, 187, 191, 193, 195, 265, 299
48Growth hormone (Genotonorm® or Omnitrope®)[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[2] 78, 193
49Guanfacine[1] Guanfacine[2] D00606 ,
D08031 		[1] ADRA2A 💬[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 193
50Guanfacine extended release (GXR)[1] Guanfacine[2] D00606 ,
D08031 		[1] ADRA2A 💬[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 193
51H01BB02----[1] 193
52Human Growth Hormone[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[4] 78, 187, 193, 265
53Humatrope 6 mg/12 mg/24 mg injektiokuiva-aine ja liuotin, liuosta varten[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
54INN Not yet proposed----[1] 193
55Intranasal oxytocin[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[2] 127, 193
56Intranasal Oxytocin (IN-OXT)[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
57Liraglutide[1] Liraglutide[1] D06404 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[3] 6, 75, 193
58Livoletide[1] Livoletide---[1] 193
59Medical air[2] Medical air,
Oxygen		[1] D00003 --[3] 85, 86, 193
60Medical Air vs Oxygen[2] Medical air,
Oxygen		[1] D00003 --[1] 193
61Metoprolol[1] Metoprolol[3] D00601 ,
D02358 ,
D05011 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 17, 57, 58, 113, 193, 226
62Metoprolol succinate[1] Metoprolol[3] D00601 ,
D02358 ,
D05011 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 57, 58, 113, 193
63METOPROLOL SUCCINATE (PH. EUR.)[1] Metoprolol[3] D00601 ,
D02358 ,
D05011 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 193
64Metoprololsuccinat Orion 25mg----[1] 193
65Metoprololsuccinat ”Orion” 25mg----[1] 193
66METYRAPONE[1] Metyrapone[2] D00410 ,
D05019 		[1] CYP11B1 💬[4] Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Steroid hormone biosynthesis 💬[2] 75, 193
67Norditropin SimpleXx----[5] 3, 78, 107, 193, 195
68Nutropin AQ----[4] 78, 134, 193, 299
69Octreotide[1] Octreotide[2] D00442 ,
D06495 		[1] SSTR2 💬[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[7] 67, 75, 84, 85, 89, 193, 227
70OMNITROPE[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[2] 78, 193
71OSSITOCINA----[1] 193
72OT----[1] 193
73Other: Control----[9] 6, 19, 67, 70, 75, 85, 97, 162, 193
74Other: Follow-up study of the untreated cohort----[1] 193
75Other: Low dose (1 mcg) ACTH stimulation test[1] Corticotropin[1] D00146 [1] MC2R 💬[5] Aldosterone synthesis and secretion, Cortisol synthesis and secretion, Cushing syndrome, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 193
76Other: Overnight metyrapone test[1] Metyrapone[2] D00410 ,
D05019 		[1] CYP11B1 💬[4] Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Steroid hormone biosynthesis 💬[1] 193
77Oxygen[1] Oxygen[1] D00003 --[20] 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
78Oxytocin[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[6] 6, 72, 127, 193, 206, 226
79Oxytocin (OXT) continuous[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
80Physiological serum (Sodium chloride)[2] Chloride ion,
Sodium chloride		[1] D02056 --[1] 193
81Pitolisant[1] Pitolisant[1] D10749 [1] HRH3 💬[1] Neuroactive ligand-receptor interaction 💬[3] 6, 113, 193
82Pitolisant oral tablets[1] Pitolisant[1] D10749 [1] HRH3 💬[1] Neuroactive ligand-receptor interaction 💬[1] 193
83Probiotic----[7] 2, 6, 93, 96, 97, 193, 266
84R05CB01----[1] 193
85RAD011----[1] 193
86Rapamycin[1] Sirolimus[1] D00753 [1] MTOR 💬[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬[19] 2, 15, 34, 35, 46, 49, 51, 60, 61, 67, 86, 89, 96, 157, 158, 193, 256, 278, 279
87RECOMBINANT HUMAN GROWTH HORMON----[1] 193
88RECOMBINANT HUMAN GROWTH HORMONE[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[3] 78, 193, 265
89Recombinant Human Growth Hormone (rhGH) Injection[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
90Recombinant Somatropin[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
91RhGH[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[4] 76, 78, 96, 193
92Rimonabant[1] Rimonabant[1] D05731 [1] CNR1 💬[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[1] 193
93RM-493----[2] 193, 202
94Sandostatin LAR[1] Octreotide[2] D00442 ,
D06495 		[1] SSTR2 💬[4] Gastric acid secretion, Growth hormone synthesis, secretion and action, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[4] 67, 84, 193, 227
95Saxenda[1] Liraglutide[1] D06404 [1] GLP1R 💬[3] Insulin secretion, Neuroactive ligand-receptor interaction, cAMP signaling pathway 💬[1] 193
96Sodium chloride[2] Chloride ion,
Sodium chloride		[1] D02056 --[21] 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 168, 193, 227, 228, 271, 288, 299
97Somatropin[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[19] 2, 3, 19, 46, 65, 74, 75, 78, 96, 107, 113, 187, 193, 195, 238, 265, 274, 276, 299
98Somatropin - adult cohort[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
99Somatropin - GH naïve pediatric cohort[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
100Somatropin - GH treated cohort[1] Somatotropin[1] D02691 [1] GHR 💬[5] Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬[1] 193
101Subcutaneous Beloranib in Suspension[1] Beloranib---[1] 193
102Syntocinon[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[3] 6, 127, 193
103Syntocinon nasal spray[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
104Syntocinon®/- Spray[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 193
105Tesofensine[1] Tesofensine---[2] 6, 193
106TESOFENSINE CITRATE[1] Tesofensine---[1] 193
107Tesofensine/Metoprolol[2] Metoprolol,
Tesofensine		[3] D00601 ,
D02358 ,
D05011 		[1] ADRB1 💬[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 193
108Tesomet----[1] 193
109TOPIRAMATE[1] Topiramate[1] D00537 [36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 97, 140, 144, 156, 193
110ZGN-440----[1] 193
111ZGN-440 for Injectable Suspension----[1] 193
112ZGN-440 sterile diluent----[1] 193