1 | Blinded CDCA 250 mg TID | [1] Chenodeoxycholic acid Chenodeoxycholic acid | [1] D00163
D00163
| [1] NR1H4 NR1H4 💬 | [1] Bile secretion Bile secretion 💬 | [1] 263 263 |
2 | Blood tests | - | - | - | - | [2] 46 46, 263 |
3 | CDCA | [1] Chenodeoxycholic acid Chenodeoxycholic acid | [1] D00163
D00163
| [1] NR1H4 NR1H4 💬 | [1] Bile secretion Bile secretion 💬 | [1] 263 263 |
4 | CDCA Weight-Based Dose TID | [1] Chenodeoxycholic acid Chenodeoxycholic acid | [1] D00163
D00163
| [1] NR1H4 NR1H4 💬 | [1] Bile secretion Bile secretion 💬 | [1] 263 263 |
5 | Chenodeoxycholic acid | [1] Chenodeoxycholic acid Chenodeoxycholic acid | [1] D00163
D00163
| [1] NR1H4 NR1H4 💬 | [1] Bile secretion Bile secretion 💬 | [4] 20 20, 96, 234, 263 |
6 | FPF1011 | - | - | - | - | [1] 263 263 |
7 | Lovastatin | [1] Lovastatin Lovastatin | [1] D00359
D00359
| [1] HMGCR HMGCR 💬 | [4] AMPK signaling pathway AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬 | [11] 6 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 |
8 | Open-Label CDCA 250 mg TID | [1] Chenodeoxycholic acid Chenodeoxycholic acid | [1] D00163
D00163
| [1] NR1H4 NR1H4 💬 | [1] Bile secretion Bile secretion 💬 | [1] 263 263 |
9 | Rescue Medication CDCA 250 mg TID | [1] Chenodeoxycholic acid Chenodeoxycholic acid | [1] D00163
D00163
| [1] NR1H4 NR1H4 💬 | [1] Bile secretion Bile secretion 💬 | [1] 263 263 |