1 | Acetate | [1] Acetate Acetate | - | - | - | [43] 1 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299 |
2 | ALX-0081 | - | - | - | - | [1] 64 64 |
3 | Anfibatide | [1] Anfibatide Anfibatide | - | - | - | [1] 64 64 |
4 | Anti-von Willebrand Factor Nanobody | [1] Von Willebrand factor human Von Willebrand factor human | - | - | - | [1] 64 64 |
5 | Anti-von Willebrand Factor Nanobody, Caplacizumab | [2] Caplacizumab Caplacizumab, Von Willebrand factor human | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
6 | Anti-von Willebrand Factor Nanobody, INN = Caplacizumab | [2] Caplacizumab Caplacizumab, Von Willebrand factor human | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
7 | Apadamtase alfa | [1] Apadamtase alfa Apadamtase alfa | - | - | - | [1] 64 64 |
8 | Apademtase alfa | - | - | - | - | [1] 64 64 |
9 | ARC 1779 | - | - | - | - | [2] 64 64, 288 |
10 | ARC1779 | - | - | - | - | [2] 64 64, 288 |
11 | ARC1779 Injection | - | - | - | - | [2] 64 64, 288 |
12 | BAX930 | - | - | - | - | [1] 64 64 |
13 | BAX930 - RECOMBINANT HUMAN ADAMTS13 | - | - | - | - | [1] 64 64 |
14 | BAX930 or SHP655 | - | - | - | - | [1] 64 64 |
15 | BORTEZOMIB | [1] Bortezomib Bortezomib | [1] D03150
D03150
| [1] PSMB5 PSMB5 💬 | [8] Alzheimer disease Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬 | [16] 11 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331 |
16 | Bortezomib Injection | [1] Bortezomib Bortezomib | [1] D03150
D03150
| [1] PSMB5 PSMB5 💬 | [8] Alzheimer disease Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬 | [1] 64 64 |
17 | CABLIVI | [1] Caplacizumab Caplacizumab | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
18 | Cablivi® | [1] Caplacizumab Caplacizumab | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
19 | CAPLACIZUMAB | [1] Caplacizumab Caplacizumab | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
20 | Caplacizumab (ALX-0081) | [1] Caplacizumab Caplacizumab | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
21 | Caplacizumab (an anti-von Willebrand Factor Nanobody ALX-0081) | [2] Caplacizumab Caplacizumab, Von Willebrand factor human | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
22 | Caplacizumab (an anti-von Willebrand Factor Nanobody) | [2] Caplacizumab Caplacizumab, Von Willebrand factor human | [1] D11160
D11160
| [1] VWF VWF 💬 | [8] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, ECM-receptor interaction, Focal adhesion, Human papillomavirus infection, Neutrophil extracellular trap formation, PI3K-Akt signaling pathway, Platelet activation 💬 | [1] 64 64 |
23 | Corticosteroid treatment (Methylprednisolone or prednisolone) | [2] Methylprednisolone Methylprednisolone, Prednisolone | [14] D00407
D00407
,
D00472
,
D00751
,
D00979
,
D00980
,
D00981
,
D00982
,
D01239
,
D01998
,
D02156
,
D03301
,
D05000
,
D05001
,
D05002
| [1] NR3C1 NR3C1 💬 | [1] Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction 💬 | [1] 64 64 |
24 | Corticosteroids | - | - | - | - | [10] 41 41, 46, 49, 64, 97, 107, 164, 220, 296, 300 |
25 | Cryosupernatant plasma | - | - | - | - | [1] 64 64 |
26 | Cyclosporine | [1] Cyclosporine Cyclosporine | [1] D00184
D00184
| [5] PPP3CA PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 | [33] Alzheimer disease Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬 | [37] 11 11, 19, 20, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 107, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302 |
27 | Danazol | [1] Danazol Danazol | [1] D00289
D00289
| [3] AR AR, ESR1, PGR 💬 | [12] Breast cancer Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬 | [5] 60 60, 63, 64, 65, 285 |
28 | Desmopressin | [1] Desmopressin Desmopressin | [2] D00291
D00291
,
D02235
| [2] AVPR2 AVPR2, F8 💬 | [4] Complement and coagulation cascades Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬 | [5] 6 6, 64, 72, 225, 288 |
29 | Desmopressin acetate | [2] Acetate Acetate, Desmopressin | [2] D00291
D00291
,
D02235
| [2] AVPR2 AVPR2, F8 💬 | [4] Complement and coagulation cascades Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬 | [2] 64 64, 288 |
30 | Dexamethasone | [1] Dexamethasone Dexamethasone | [9] D00292
D00292
,
D00975
,
D01510
,
D01615
,
D01632
,
D01948
,
D02174
,
D02591
,
D02592
| [1] NR3C1 NR3C1 💬 | [1] Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction 💬 | [25] 13 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299 |
31 | HMED-IdeS | [1] Imlifidase Imlifidase | [1] D11470
D11470
| - | - | [2] 64 64, 221 |
32 | IDEC-C2B8, Ro 45-2294 | - | - | - | - | [1] 64 64 |
33 | IdeS | [1] Imlifidase Imlifidase | [1] D11470
D11470
| - | - | [2] 64 64, 221 |
34 | IdeS (0.25 mg/kg) | [1] Imlifidase Imlifidase | [1] D11470
D11470
| - | - | [1] 64 64 |
35 | IdeS (0.50 mg/kg) | [1] Imlifidase Imlifidase | [1] D11470
D11470
| - | - | [1] 64 64 |
36 | Immunosuppressive treatment (eg, rituximab) | [1] Rituximab Rituximab | [1] D02994
D02994
| [1] MS4A1 MS4A1 💬 | [1] Hematopoietic cell lineage Hematopoietic cell lineage 💬 | [1] 64 64 |
37 | MabThera | [1] Rituximab Rituximab | [1] D02994
D02994
| [1] MS4A1 MS4A1 💬 | [1] Hematopoietic cell lineage Hematopoietic cell lineage 💬 | [22] 11 11, 13, 14, 19, 35, 43, 44, 46, 49, 50, 51, 52, 53, 61, 63, 64, 65, 83, 93, 162, 222, 271 |
38 | Magnesium | [1] Magnesium Magnesium | - | - | - | [19] 3 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298 |
39 | MASP-2 antibody | [1] Narsoplimab Narsoplimab | [1] D11531
D11531
| [1] MASP2 MASP2 💬 | [3] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬 | [3] 64 64, 66, 109 |
40 | Methylprednisolone | [1] Methylprednisolone Methylprednisolone | [6] D00407
D00407
,
D00751
,
D00979
,
D05000
,
D05001
,
D05002
| [1] NR3C1 NR3C1 💬 | [1] Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction 💬 | [48] 2 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300 |
41 | Minirin | [1] Desmopressin Desmopressin | [2] D00291
D00291
,
D02235
| [2] AVPR2 AVPR2, F8 💬 | [4] Complement and coagulation cascades Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬 | [2] 64 64, 288 |
42 | Octaplas | [1] Plasma protein fraction (human) Plasma protein fraction (human) | - | - | - | [1] 64 64 |
43 | Octaplas infusion | [1] Plasma protein fraction (human) Plasma protein fraction (human) | - | - | - | [1] 64 64 |
44 | Octaplas SD | [1] Plasma protein fraction (human) Plasma protein fraction (human) | - | - | - | [1] 64 64 |
45 | OctaplasLG® | - | - | - | - | [1] 64 64 |
46 | Octaplas®LG | [1] Plasma protein fraction (human) Plasma protein fraction (human) | - | - | - | [1] 64 64 |
47 | Octostim | - | - | - | - | [2] 64 64, 288 |
48 | OMS721 | - | - | - | - | [3] 64 64, 66, 109 |
49 | OMS721 100 mg/ml Injection solution, OMS00620646, OMS620646, MASP-2 Antibody | [1] Narsoplimab Narsoplimab | [1] D11531
D11531
| [1] MASP2 MASP2 💬 | [3] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬 | [2] 64 64, 109 |
50 | OMS721 185 mg/ml Injection solution, OMS00620646, OMS620646, MASP-2 Antibody | [1] Narsoplimab Narsoplimab | [1] D11531
D11531
| [1] MASP2 MASP2 💬 | [3] Complement and coagulation cascades Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬 | [2] 64 64, 109 |
51 | Other: standard of care | - | - | - | - | [7] 13 13, 49, 64, 85, 96, 245, 246 |
52 | Plasma exchange | - | - | - | - | [5] 13 13, 43, 44, 64, 222 |
53 | Plasma exchange (PE) | - | - | - | - | [3] 64 64, 66, 220 |
54 | Pooled Plasma (Human), Solvent/Detergent Treated | - | - | - | - | [1] 64 64 |
55 | PREDNISOLONE | [1] Prednisolone Prednisolone | [8] D00472
D00472
,
D00980
,
D00981
,
D00982
,
D01239
,
D01998
,
D02156
,
D03301
| [1] NR3C1 NR3C1 💬 | [1] Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction 💬 | [43] 3 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307 |
56 | Prednisone | [1] Prednisone Prednisone | [1] D00473
D00473
| [1] NR3C1 NR3C1 💬 | [1] Neuroactive ligand-receptor interaction Neuroactive ligand-receptor interaction 💬 | [48] 2 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 |
57 | RADAMTS-13 | - | - | - | - | [1] 64 64 |
58 | Recombinant A Disintegrin and Metalloproteinase Thrombospondin Type-1 Motifs 13 | - | - | - | - | [1] 64 64 |
59 | Recombinant A Disintegrin and Metalloproteinase with Thrombospondin Type-1 | - | - | - | - | [1] 64 64 |
60 | Recombinant A Disintegrin and Metalloproteinase with Thrombospondin Type-1 Motifs | - | - | - | - | [1] 64 64 |
61 | Recombinant A Disintegrin and Metalloproteinase with Thrombospondin Type-1 Motifs 13 | - | - | - | - | [1] 64 64 |
62 | Recombinant A Disintegrin And Metalloproteinase with Thrombospondin Type-1 Motifs 13 (rADAMTS13) | - | - | - | - | [1] 64 64 |
63 | Recombinant ADAMTS13 | - | - | - | - | [1] 64 64 |
64 | Rituximab | [1] Rituximab Rituximab | [1] D02994
D02994
| [1] MS4A1 MS4A1 💬 | [1] Hematopoietic cell lineage Hematopoietic cell lineage 💬 | [49] 6 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 |
65 | Romiplostim | [1] Romiplostim Romiplostim | [1] D08990
D08990
| [1] MPL MPL 💬 | [2] Cytokine-cytokine receptor interaction Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway 💬 | [4] 60 60, 63, 64, 65 |
66 | SHP 655 (BAX 930) | - | - | - | - | [1] 64 64 |
67 | SHP655 | - | - | - | - | [1] 64 64 |
68 | Standard of Care | - | - | - | - | [10] 6 6, 13, 46, 49, 51, 63, 64, 79, 171, 271 |
69 | Standard Plasma | - | - | - | - | [1] 64 64 |
70 | Standrd of Care treatment | - | - | - | - | [1] 64 64 |
71 | Sulfate | [1] Sulfate ion Sulfate ion | - | - | - | [27] 2 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299 |
72 | Sulfate, Magnesium | [2] Magnesium Magnesium, Sulfate ion | - | - | - | [1] 64 64 |
73 | TAK-755 | - | - | - | - | [1] 64 64 |
74 | TAK-755 or BAX930 or SHP655 | - | - | - | - | [1] 64 64 |
75 | TAK-755 orBAX930 or SHP655 | - | - | - | - | [1] 64 64 |
76 | Uniplas | - | - | - | - | [1] 64 64 |
77 | Von willebrand factor | [1] Von Willebrand factor human Von Willebrand factor human | - | - | - | [2] 64 64, 288 |