Drug Description in Trials / DrugBank / KEGG DRUG /

  

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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
10.5% marcaine----[1] 70
20.9% saline----[2] 6, 70
30002-8971----[1] 70
41mg/kg/hr TXA intravenous infusion till the last suture----[1] 70
5Acetaminophen[1] Acetaminophen[1] D00217 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[16] 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
6Acetate[1] Acetate---[43] 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
7Acupuncture----[2] 46, 70
8Adjunctive analgesics----[1] 70
9Adjunctive anti-depressants----[1] 70
10AK1320 MS----[1] 70
11AlloGen-LI----[1] 70
12Allograft----[1] 70
13Alprostadil[1] Alprostadil[2] D00180 ,
D02705 		[1] PTGER1 💬[4] Calcium signaling pathway, Human cytomegalovirus infection, Neuroactive ligand-receptor interaction, Pathways in cancer 💬[2] 51, 70
14Amino acids[1] Amino acids---[3] 70, 240, 298
15Aminocaproic acid[1] Aminocaproic acid[1] D00160 [1] PLG 💬[4] Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬[1] 70
16Amniotic Fluid Allograft----[1] 70
17Apple[1] Apple---[1] 70
18Apple Watch and App[1] Apple---[1] 70
19Bee venom pharmacopuncture----[1] 70
20Bilateral transforaminal epidural steroid injections----[1] 70
21Bioactive Glass-Ceramic Spacer----[1] 70
22Bone Marrow Concentrate----[1] 70
23BOTULINUM TOXIN TYPE A[1] Botulinum toxin type A[1] D00783 [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[10] 2, 5, 6, 7, 13, 15, 17, 70, 113, 149
24Botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle[1] Botulinum toxin type A[1] D00783 [1] SNAP25 💬[2] Insulin secretion, Synaptic vesicle cycle 💬[1] 70
25Bupivacaine[1] Bupivacaine[2] D01450 ,
D07552 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[8] 46, 51, 53, 70, 96, 168, 226, 298
26Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine[3] Bupivacaine,
Clonidine,
Epinephrine		[7] D00095 ,
D00281 ,
D00604 ,
D00996 ,
D01450 ,
D02149 ,
D07552 		[14] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[16] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Taste transduction, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 70
27Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml[1] Sufentanil[2] D00845 ,
D05938 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
28Buprenorphine[1] Buprenorphine[2] D00836 ,
D07132 		[2] OPRK1,
OPRM1 💬		[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[3] 46, 70, 298
29Caudal epidural injection----[1] 70
30Caudal Epidural Injection with Celestone----[1] 70
31Caudal Epidural Injection with DepoMedrol----[1] 70
32Caudal Epidural Injection with generic Celestone----[1] 70
33Celebrex 200Mg Capsule----[1] 70
34Celecoxib[1] Celecoxib[1] D00567 [1] PTGS2 💬[22] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[10] 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
35Cervical Orthosis (CO)----[1] 70
36Chuna manipulation----[1] 70
37Chuna manual medicine----[1] 70
38CILOSTAZOL[1] Cilostazol[1] D01896 [3] PDE3A,
PDE3B,
TBXA2R 💬		[14] Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 51, 70, 124
39Clonidine[1] Clonidine[2] D00281 ,
D00604 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[4] 6, 65, 70, 78
40CO----[6] 6, 13, 53, 70, 85, 149
41Combination Product: Goldic serum----[1] 70
42CONDUIT™ Interbody Platform composed of the EIT (Emerging Implant Technologies) Cellular Titanium®[1] Titanium---[1] 70
43Control group----[5] 2, 34, 46, 70, 235
44Creatinine[1] Creatinine[1] D03600 --[4] 2, 46, 60, 70
45Cupping----[1] 70
46Darvocet----[1] 70
47Decadron Phosphate, Injectable[1] Phosphate ion---[1] 70
48Deksmedetomidiini----[1] 70
49Demineralized Bone Matrix----[1] 70
50DepoMedrol----[1] 70
51Dexamethasone[1] Dexamethasone[9] D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[25] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
52DEXAMETHASONE SODIUM PHOSPHATE[2] Dexamethasone,
Phosphate ion		[9] D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[3] 65, 70, 96
53Dexdor[1] Dexmedetomidine[2] D00514 ,
D01205 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[4] 2, 4, 6, 70
54DEXMEDETOMIDINE[1] Dexmedetomidine[2] D00514 ,
D01205 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[13] 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
55Dexmedetomidine group[1] Dexmedetomidine[2] D00514 ,
D01205 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 70
56DEXMEDETOMIDINE HYDROCHLORIDE[1] Dexmedetomidine[2] D00514 ,
D01205 		[3] ADRA2A,
ADRA2B,
ADRA2C 💬		[2] Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬[1] 70
57Dexmedetomidine with ropivacaine[2] Dexmedetomidine,
Ropivacaine		[4] D00514 ,
D01205 ,
D04048 ,
D08490 		[8] ADRA2A,
ADRA2B,
ADRA2C,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[5] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Neuroactive ligand-receptor interaction, Taste transduction, cGMP-PKG signaling pathway 💬[1] 70
58Dextrose[1] Dextrose, unspecified form---[5] 56, 60, 65, 70, 226
59Diphenhydramine[1] Diphenhydramine[6] D00300 ,
D00669 ,
D02419 ,
D03285 ,
D03360 ,
D03854 		[1] HRH1 💬[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬[10] 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
60EACA[1] Aminocaproic acid[1] D00160 [1] PLG 💬[4] Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬[1] 70
61Electroacupuncture----[2] 6, 70
62Epidural injection----[1] 70
63Epidural local anesthetic injection----[1] 70
64Epidural steroid (dexamethasone) injection[1] Dexamethasone[9] D00292 ,
D00975 ,
D01510 ,
D01615 ,
D01632 ,
D01948 ,
D02174 ,
D02591 ,
D02592 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 70
65Epidural Steroid Injection----[1] 70
66Epidural steroid with local anesthetic injection----[1] 70
67Epinephrine[1] Epinephrine[3] D00095 ,
D00996 ,
D02149 		[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬		[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[3] 46, 70, 96
68Epsilon-Aminocaproic Acid (EACA)[1] Aminocaproic acid[1] D00160 [1] PLG 💬[4] Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬[1] 70
69Erector spinae plane block (Group E)----[1] 70
70ERYTHROPOIETIN[1] Erythropoietin[1] D03231 [1] EPOR 💬[5] Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬[9] 2, 6, 13, 18, 22, 47, 70, 95, 96
71ESKETAMINE[1] Esketamine[1] D07283 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[3] 2, 4, 70
72ESKETAMINE HYDROCHLORIDE[1] Esketamine[1] D07283 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[1] 70
73Fentanyl[1] Fentanyl[2] D00320 ,
D01399 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[4] 46, 70, 215, 231
74Forsteo[1] Teriparatide[1] D06078 [1] PTH1R 💬[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[3] 70, 235, 274
75Forteo[1] Teriparatide[1] D06078 [1] PTH1R 💬[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[1] 70
76Fusion[1] Iron polymaltose---[7] 11, 13, 46, 49, 69, 70, 271
77GABAPENTIN[1] Gabapentin[1] D00332 [5] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		[9] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬[5] 6, 13, 19, 70, 298
78Heparin[1] Heparin[1] D07510 [1] SERPINC1 💬[1] Complement and coagulation cascades 💬[12] 47, 60, 70, 79, 84, 107, 224, 226, 280, 299, 316, 317
79Herbal medicine----[1] 70
80Hyaluronic acid[1] Hyaluronic acid[1] D08043 --[5] 46, 53, 70, 226, 231
81Hydromorphone[1] Hydromorphone[2] D00839 ,
D08047 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
82I-FACTOR----[1] 70
83Interbody cage (PEEK)----[1] 70
84Interbody cage (titanium)[1] Titanium---[1] 70
85Kenalog Injectable Product----[1] 70
86KETAMINE[1] Ketamine[2] D00711 ,
D08098 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[6] 6, 13, 70, 113, 156, 215
87Ketanest----[3] 2, 4, 70
88Ketanest-S----[3] 2, 4, 70
89Ketorolac[1] Ketorolac[2] D00813 ,
D08104 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[2] 70, 226
90Lidocaine[1] Lidocaine[3] D00358 ,
D02086 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[12] 6, 13, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256
91Lidocaine Hydrochloride, Injectable[1] Lidocaine[3] D00358 ,
D02086 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 70
92Limaprost[1] Limaprost[1] D02722 [1] PTGER1 💬[4] Calcium signaling pathway, Human cytomegalovirus infection, Neuroactive ligand-receptor interaction, Pathways in cancer 💬[1] 70
93Liposomal bupivacaine[1] Bupivacaine[2] D01450 ,
D07552 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[3] 51, 70, 96
94Lumbar epidural injection----[1] 70
95Lumbar Interbody Fusion with Autograft[1] Iron polymaltose---[1] 70
96Lumbar Interbody Fusion with NeoFuse[1] Iron polymaltose---[1] 70
97Lumbar interlaminar epidural steroid injection----[1] 70
98Magnesium[1] Magnesium---[19] 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
99Magnesium with ropivacaine[2] Magnesium,
Ropivacaine		[2] D04048 ,
D08490 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 70
100Manual therapy----[1] 70
101MasterGraft Granules----[1] 70
102Mecobalamin[1] Mecobalamin[1] D03246 --[2] 2, 70
103Midazolam[1] Midazolam[3] D00550 ,
D00696 ,
D05028 		[16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[12] 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
104MILD Procedure----[1] 70
105MILD® (Minimally Invasive Lumbar Decompression)----[1] 70
106Mirogabalin[1] Mirogabalin[1] D11203 [2] CACNA2D1,
CACNA2D2 💬		[7] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬[1] 70
107Misoprostol[1] Misoprostol[1] D00419 [3] PTGER2,
PTGER3,
PTGER4 💬		[9] Calcium signaling pathway, Human cytomegalovirus infection, Human papillomavirus infection, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways in cancer, Regulation of lipolysis in adipocytes, Renin secretion, cAMP signaling pathway 💬[3] 46, 70, 271
108Modal----[5] 2, 6, 17, 46, 70
109Modified-thoracolumbar interfascial plane block----[1] 70
110MONITOR[1] Methamidophos---[20] 2, 11, 13, 19, 28, 46, 49, 58, 65, 70, 81, 85, 86, 98, 113, 118, 129, 298, 299, 300
111Morphine[1] Morphine[3] D00842 ,
D02271 ,
D08233 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[6] 36, 46, 70, 85, 86, 298
112Morphine PCA[1] Morphine[3] D00842 ,
D02271 ,
D08233 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
113MRI----[5] 13, 70, 78, 85, 278
114Multi-modal pain management [Acetaminophen + Gabapentin][2] Acetaminophen,
Gabapentin		[2] D00217 ,
D00332 		[7] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
PTGS1,
PTGS2,
SLC6A1 💬		[31] Adrenergic signaling in cardiomyocytes, Alzheimer disease, Arachidonic acid metabolism, Arrhythmogenic right ventricular cardiomyopathy, C-type lectin receptor signaling pathway, Cardiac muscle contraction, Chemical carcinogenesis - DNA adducts, Dilated cardiomyopathy, GABAergic synapse, Human cytomegalovirus infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, MAPK signaling pathway, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, Synaptic vesicle cycle, TNF signaling pathway, VEGF signaling pathway 💬[1] 70
115Multi-modal pain management [Fentanyl][1] Fentanyl[2] D00320 ,
D01399 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
116Multi-modal pain management [Intravenous Ketamine][1] Ketamine[2] D00711 ,
D08098 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[1] 70
117Multi-modal pain management [Valium + Gabapentin][1] Gabapentin[1] D00332 [5] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
SLC6A1 💬		[9] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway, Synaptic vesicle cycle 💬[1] 70
118NeoFuse----[1] 70
119Nicardipine[1] Nicardipine[2] D00617 ,
D08270 		[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 70, 86
120Normal Saline----[18] 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299
121NS-304----[3] 70, 86, 88
122NS-304 Placebo----[2] 70, 88
123NSAIDs----[4] 46, 70, 107, 271
124NuCel----[1] 70
125Oksikodoni----[1] 70
126Opana[1] Oxymorphone[1] D08323 [1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
127Other intervention(s)----[1] 70
128Other: Control----[9] 6, 19, 67, 70, 75, 85, 97, 162, 193
129Other: Conventional PCA mode----[1] 70
130Other: Epiduroscopy----[1] 70
131Other: Group Exercise: community setting----[1] 70
132Other: Individualized exercises: clinical setting----[1] 70
133Other: Joint Mobilizations (spine, sacroiliac, hip)----[1] 70
134Other: NO intervention----[4] 13, 70, 96, 97
135Other: Optimizing basal infusion (B.I)----[1] 70
136Other: Other intervention(s)----[1] 70
137Other: Physical Therapy----[2] 6, 70
138Oxanest----[1] 70
139Oxycodone[1] Oxycodone[3] D03783 ,
D05312 ,
D05462 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[7] 6, 13, 46, 70, 226, 231, 298
140OXYCODONE HYDROCHLORIDE[1] Oxycodone[3] D03783 ,
D05312 ,
D05462 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[4] 6, 70, 226, 298
141Oxycodone Orion[1] Oxycodone[3] D03783 ,
D05312 ,
D05462 		[3] OPRD1,
OPRK1,
OPRM1 💬		[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬[1] 70
142Oxygen[1] Oxygen[1] D00003 --[20] 6, 13, 19, 46, 49, 70, 84, 85, 86, 88, 90, 96, 97, 168, 193, 226, 271, 294, 299, 330
143Parathyroid hormone[1] Parathyroid hormone[1] D05364 [2] PTH1R,
PTH2R 💬		[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[2] 70, 235
144PCA----[2] 46, 70
145Percutaneous Lumbar Decompression----[1] 70
146Pharmacopuncture----[1] 70
147Philips Intelivue MP70 monitor[1] Methamidophos---[1] 70
148Phosphate[1] Phosphate ion---[33] 2, 3, 6, 11, 12, 13, 15, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
149Pleth Variability Index (PVI)----[1] 70
150PLF with autograft----[1] 70
151PLF with NeoFuse----[1] 70
152POLYDEOXYRIBONUCLEOTIDES----[2] 51, 70
153Posterolateral spinal fusion with instrumentation[1] Iron polymaltose---[1] 70
154Predinose oral----[1] 70
155Pregabalin[1] Pregabalin[1] D02716 [4] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		[7] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬[5] 13, 36, 46, 70, 298
156Pregabalin 75mg[1] Pregabalin[1] D02716 [4] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4 💬		[7] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, MAPK signaling pathway, Oxytocin signaling pathway 💬[1] 70
157Prolotherapy solution of 20% dextrose[1] Dextrose, unspecified form---[1] 70
158PROPOFOL[1] Propofol[1] D00549 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[9] 6, 21, 22, 34, 46, 70, 84, 98, 296
159Propofol Injection[1] Propofol[1] D00549 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 70
160Remifentanil[1] Remifentanil[2] D01177 ,
D08473 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[2] 6, 70
161RhPTH[1] Parathyroid hormone[1] D05364 [2] PTH1R,
PTH2R 💬		[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[3] 70, 235, 326
162RhPTH (1-34)[1] Parathyroid hormone[1] D05364 [2] PTH1R,
PTH2R 💬		[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[1] 70
163Ropivacaine[1] Ropivacaine[2] D04048 ,
D08490 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[3] 36, 46, 70
164Ropivacaine plus normal saline[1] Ropivacaine[2] D04048 ,
D08490 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 70
165S-ketamine[2] Esketamine,
Ketamine		[3] D00711 ,
D07283 ,
D08098 		[5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[1] 70
166S-ketamine & midazolam[3] Esketamine,
Ketamine,
Midazolam		[6] D00550 ,
D00696 ,
D00711 ,
D05028 ,
D07283 ,
D08098 		[21] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[25] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Systemic lupus erythematosus, Taste transduction, cAMP signaling pathway 💬[1] 70
167Selective Nerve Root Block----[1] 70
168Selexipag[1] Selexipag[1] D09994 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[6] 47, 51, 70, 84, 86, 88
169Standard analgesia use [Fentanyl][1] Fentanyl[2] D00320 ,
D01399 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
170Standard analgesia use [Hydromorphone][1] Hydromorphone[2] D00839 ,
D08047 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[1] 70
171Standard analgesia use [Oxygen][1] Oxygen[1] D00003 --[1] 70
172Standard analgesia use [Volatile Anesthesia]----[1] 70
173Steroid injections----[1] 70
174Sufentanil[1] Sufentanil[2] D00845 ,
D05938 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[2] 70, 280
175Sugar pill----[8] 5, 6, 49, 67, 70, 86, 206, 210
176Teicoplanin[1] Teicoplanin[1] D02142 --[2] 70, 299
177Teriparatide[1] Teriparatide[1] D06078 [1] PTH1R 💬[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[6] 46, 68, 70, 71, 235, 274
178Teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34)[2] Parathyroid hormone,
Teriparatide		[2] D05364 ,
D06078 		[2] PTH1R,
PTH2R 💬		[3] Endocrine and other factor-regulated calcium reabsorption, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action 💬[1] 70
179Therm-AppTM TH, thermographic camera----[1] 70
180Titanium[1] Titanium---[2] 69, 70
181Titanium cage[1] Titanium---[1] 70
182Tramadol[1] Tramadol[2] D01355 ,
D08623 		[1] OPRM1 💬[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬[5] 46, 70, 78, 226, 271
183Tramadol with ropivacaine[2] Ropivacaine,
Tramadol		[4] D01355 ,
D04048 ,
D08490 ,
D08623 		[6] OPRM1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[6] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction 💬[1] 70
184Tranexamic acid[1] Tranexamic acid[1] D01136 [1] PLG 💬[4] Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬[6] 46, 70, 215, 227, 288, 299
185Tranexamic Acid 100 MG/ML[1] Tranexamic acid[1] D01136 [1] PLG 💬[4] Complement and coagulation cascades, Influenza A, Neuroactive ligand-receptor interaction, Staphylococcus aureus infection 💬[1] 70
186Transdermal fentanyl matrix, gabapentin[2] Fentanyl,
Gabapentin		[3] D00320 ,
D00332 ,
D01399 		[6] CACNA2D1,
CACNA2D2,
CACNA2D3,
CACNA2D4,
OPRM1,
SLC6A1 💬		[12] Adrenergic signaling in cardiomyocytes, Arrhythmogenic right ventricular cardiomyopathy, Cardiac muscle contraction, Dilated cardiomyopathy, Estrogen signaling pathway, GABAergic synapse, Hypertrophic cardiomyopathy, MAPK signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Synaptic vesicle cycle 💬[1] 70
187Transforaminal Epidural Injection----[1] 70
188Triamcinolone[1] Triamcinolone[5] D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[10] 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
189Triamcinolone Acetonide and normal saline solution[1] Triamcinolone[5] D00385 ,
D00983 ,
D00984 ,
D00985 ,
D06216 		[1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[1] 70
190Tylenol----[1] 70
191Vancomycin[1] Vancomycin[2] D00212 ,
D00926 		--[7] 46, 70, 94, 96, 97, 296, 299
192ViviGen Cellular Bone Matrix----[1] 70
193With U-VANCO (vancomycin hydrochloride)[1] Vancomycin[2] D00212 ,
D00926 		--[1] 70
194Without U-VANCO (vancomycin hydrochloride)[1] Vancomycin[2] D00212 ,
D00926 		--[1] 70
195Wound topically irrigated with 500mg TXA----[1] 70
196Xylocaine[1] Lidocaine[3] D00358 ,
D02086 ,
D08127 		[5] SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬[1] 70