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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
111C-CSar----[2] 93, 94
23108006977----[1] 94
3[18F]FP-R01-MG-F2----[2] 85, 94
4Acetylcysteine[1] Acetylcysteine[1] D00221 --[20] 6, 13, 19, 20, 34, 49, 51, 53, 58, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
5ACIDO DEOSSICOLICO----[1] 94
6Acido Obeticolico----[2] 93, 94
7All-trans retinoic acid[1] Tretinoin[1] D00094 [3] PML,
RARA,
RARB 💬		[12] Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis 💬[1] 94
8ATRA[1] Tretinoin[1] D00094 [3] PML,
RARA,
RARB 💬		[12] Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis 💬[2] 63, 94
9Azathioprine[1] Azathioprine[2] D00238 ,
D03033 		--[21] 6, 11, 13, 19, 35, 42, 43, 44, 45, 46, 49, 63, 65, 66, 85, 93, 94, 95, 96, 97, 162
10AZT----[3] 94, 265, 325
11Befizal----[1] 94
12BEFIZAL L.P. 400 mg, comprimé enrobé à libération prolongée----[1] 94
13Bezafibrate[1] Bezafibrate[1] D01366 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[7] 20, 93, 94, 160, 296, 316, 324
14Bezafibrate (400mg) in addition to standard 15-20 mg/kg/jour UDCA therapy[2] Bezafibrate,
Ursodeoxycholic acid		[2] D00734 ,
D01366 		[2] NR1H4,
PPARA 💬		[11] Adipocytokine signaling pathway, Alcoholic liver disease, Bile secretion, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[1] 94
15Bezalip----[3] 93, 94, 160
16BTT1023----[1] 94
17BTT1023 IV Infusion 20 mg/mL, 5 mL Drug Product----[1] 94
18BUDESONIDE[1] Budesonide[1] D00246 [1] NR3C1 💬[1] Neuroactive ligand-receptor interaction 💬[9] 66, 93, 94, 95, 96, 97, 98, 228, 299
19C10AB02----[1] 94
20Calcium[1] Calcium---[30] 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
21Capecitabine[1] Capecitabine[1] D01223 [1] TYMS 💬[4] Antifolate resistance, Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism 💬[1] 94
22Cenicriviroc[1] Cenicriviroc[1] D09878 [2] CCR2,
CCR5 💬		[9] Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Toxoplasmosis, Viral carcinogenesis, Viral protein interaction with cytokine and cytokine receptor 💬[1] 94
23Cenicriviroc 150 mg[1] Cenicriviroc[1] D09878 [2] CCR2,
CCR5 💬		[9] Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Toxoplasmosis, Viral carcinogenesis, Viral protein interaction with cytokine and cytokine receptor 💬[1] 94
24CILO----[1] 94
25Cilofexor[1] Cilofexor---[2] 93, 94
26Cis-4-Hydroxy-L-Proline[1] Proline[1] D00035 --[1] 94
27CLADRIBINE[1] Cladribine[1] D01370 [1] RRM1 💬[5] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬[3] 11, 13, 94
28CM-101----[1] 94
29CS0159----[1] 94
30Curcumin[1] Curcumin---[11] 2, 13, 46, 49, 67, 74, 94, 96, 97, 139, 299
31DHA----[8] 6, 46, 48, 49, 94, 113, 299, 301
32Docosahexaenoic acid[1] Doconexent---[7] 6, 49, 90, 94, 240, 299, 301
33Docosahexaenoic Acid (DHA)[1] Doconexent---[3] 6, 94, 299
34DUR-928----[1] 94
35Engineered recombinant human FGF19----[1] 94
36Entyvio[1] Vedolizumab[1] D08083 [2] ITGA4,
ITGB7 💬		[15] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer, Yersinia infection 💬[3] 94, 96, 97
37Erlotinib[1] Erlotinib[2] D04023 ,
D07907 		[1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 94
38Erlotinib (Tarceva)[1] Erlotinib[2] D04023 ,
D07907 		[1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 94
39Fecal microbiota transplantation----[5] 2, 66, 94, 96, 97
40Fenofibrate[1] Fenofibrate[1] D00565 [1] PPARA 💬[10] Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬[5] 8, 79, 93, 94, 265
41Fluimucil----[4] 85, 94, 193, 298
42FLUIMUCIL*20CPR EFF 600MG----[2] 94, 298
43Gluten-free diet----[1] 94
44GS-6624[1] Simtuzumab---[2] 85, 94
45GS-9674----[2] 93, 94
46HTD1801----[1] 94
47Humanised IgG1 monoclonal antibody against human eotaxin-2----[1] 94
48ICG----[3] 93, 94, 235
49INT-747, OCA----[2] 93, 94
50Liver transplantation----[1] 94
51LUM001----[4] 93, 94, 297, 338
52MBX-8025----[3] 79, 93, 94
53METRONIDAZOLE[1] Metronidazole[3] D00409 ,
D05016 ,
D05017 		--[8] 46, 51, 63, 94, 95, 96, 97, 291
54Minocycline[1] Minocycline[2] D00850 ,
D05045 		--[13] 2, 6, 8, 13, 46, 85, 90, 94, 162, 201, 206, 280, 299
55Mitomycin[1] Mitomycin[1] D00208 --[2] 94, 329
56Mitomycin C[1] Mitomycin[1] D00208 --[1] 94
57Mizoribine[1] Mizoribine[1] D01392 [2] IMPDH1,
IMPDH2 💬		[3] Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬[8] 46, 49, 51, 53, 66, 94, 222, 224
58MLN0002----[3] 94, 96, 97
59NGM282----[2] 93, 94
60Normal Saline----[18] 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299
61Norucholic acid[1] norUrsodeoxycholic acid---[2] 93, 94
62NorUDCA----[1] 94
63NorUDCA (Norursodeoxycholic acid)[1] norUrsodeoxycholic acid---[1] 94
64NorUrsodeoxycholic Acid[1] norUrsodeoxycholic acid---[1] 94
65Norursodeoxycholic acid, NCA[1] norUrsodeoxycholic acid---[1] 94
66OCA----[2] 94, 296
67OCA 1,5 mg----[1] 94
68OCA 5 mg----[1] 94
69Oral all-trans retinoic acid (ATRA)[1] Tretinoin[1] D00094 [3] PML,
RARA,
RARB 💬		[12] Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis 💬[1] 94
70Oral Vancomycin[1] Vancomycin[2] D00212 ,
D00926 		--[2] 94, 296
71Orbcel-C[1] Allogenic Donor CD362-enriched Human Umbilical Cord-derived Mesenchymal Stem Cells---[2] 94, 95
72PHENYLBUTYRATE[1] Phenylbutyric acid---[12] 2, 3, 6, 8, 15, 93, 94, 244, 251, 297, 299, 338
73PLN-74809----[2] 85, 94
74Potassium[1] Potassium[1] D08403 --[12] 36, 46, 66, 67, 88, 94, 98, 115, 167, 179, 215, 235
75Pre liver transplantation laparoscopic hand assisted staging----[1] 94
76Probiotics----[5] 6, 94, 96, 97, 291
77Proline[1] Proline[1] D00035 --[2] 94, 97
78Radiation: 45 Gy external radiations----[1] 94
79Radiation: Endoluminal bile duct Brachytherapy----[1] 94
80Rec-h-FGF19----[1] 94
81Retinoic acid[1] Tretinoin[1] D00094 [3] PML,
RARA,
RARB 💬		[12] Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis 💬[2] 94, 231
82Rituximab[1] Rituximab[1] D02994 [1] MS4A1 💬[1] Hematopoietic cell lineage 💬[49] 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
83SELADELPAR[1] Seladelpar[1] D11256 [1] PPARG 💬[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬[2] 93, 94
84Simtuzimab----[1] 94
85Simtuzumab[1] Simtuzumab---[2] 85, 94
86Simvastatin[1] Simvastatin[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
87Simvastatin 40mg[1] Simvastatin[1] D00434 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[1] 94
88SULFASALAZINE[1] Sulfasalazine[1] D00448 --[6] 46, 86, 94, 107, 270, 271
89TBC----[3] 85, 94, 96
90Thalidomide[1] Thalidomide[1] D00754 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
91UCMSC----[2] 51, 94
92UDCA[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[6] 46, 67, 93, 94, 97, 296
93Ursodeoxycholic acid[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[9] 6, 46, 67, 84, 93, 94, 95, 96, 97
94Ursodeoxycholic acid (UDCA)[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[1] 94
95Ursofalk[1] Ursodeoxycholic acid[1] D00734 [1] NR1H4 💬[1] Bile secretion 💬[4] 93, 94, 96, 97
96Ursolic acid[1] Ursolic acid---[1] 94
97Vancomycin[1] Vancomycin[2] D00212 ,
D00926 		--[7] 46, 70, 94, 96, 97, 296, 299
98VEDOLIZUMAB[1] Vedolizumab[1] D08083 [2] ITGA4,
ITGB7 💬		[15] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer, Yersinia infection 💬[3] 94, 96, 97
99Vedolizumab IV[1] Vedolizumab[1] D08083 [2] ITGA4,
ITGB7 💬		[15] Arrhythmogenic right ventricular cardiomyopathy, Cell adhesion molecules, Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Human papillomavirus infection, Hypertrophic cardiomyopathy, Intestinal immune network for IgA production, Leishmaniasis, Leukocyte transendothelial migration, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Transcriptional misregulation in cancer, Yersinia infection 💬[3] 94, 96, 97
100Vidofludimus[1] Vidofludimus---[5] 13, 46, 94, 96, 97
101VIDOFLUDIMUS CALCIUM[2] Calcium,
Vidofludimus		---[4] 13, 94, 96, 97
102Volixibat[1] Volixibat[1] D11007 --[2] 93, 94
103Volixibat (formely SHP626, LUM002 or SAR548304B)[1] Volixibat[1] D11007 --[1] 94
104Volixibat potassium[2] Potassium,
Volixibat		[2] D08403 ,
D11007 		--[1] 94
105Xifaxan[1] Rifaximin[1] D02554 --[2] 65, 94