Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank Drug (Description in trials) KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1 Ianalumab [1] Ianalumab[1] D12151 [1] TNFRSF13C 💬[5] Cytokine-cytokine receptor interaction, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, NF-kappa B signaling pathway, Primary immunodeficiency 💬[5] 35, 46, 49, 53, 95
2 Ibandronate [2] Ibandronate; Ibandronic acid[1] D08056 [1] FDPS 💬[4] Human T-cell leukemia virus 1 infection, Influenza A, Metabolic pathways, Terpenoid backbone biosynthesis 💬[3] 46, 49, 274
3 Ibrutinib [1] Ibrutinib[1] D10223 [1] BTK 💬[7] B cell receptor signaling pathway, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, Primary immunodeficiency 💬[3] 28, 60, 61
4 Ibudilast [1] IBUDILAST[1] D01385 [8] CYSLTR1,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PTGIR 💬		[16] Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Parathyroid hormone synthesis, secretion and action, Platelet activation, Progesterone-mediated oocyte maturation, Purine metabolism, Regulation of lipolysis in adipocytes, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[2] 2, 13
5 Ibuprofen [2] Ibuprofen; IBUPROFEN 200MG[4] D00126 ,
D01122 ,
D04490 ,
D06606 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[7] 13, 46, 65, 107, 113, 271, 299
6 Icosapent [2] Eicosapentaenoic acid; Icosapent[1] D08061 --[11] 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338
7 Icosapent ethyl [2] Ethyl-EPA; Icosapent[1] D01892 --[2] 8, 296
8 Icotinib [1] Icotinib[1] D11251 [1] EGFR 💬[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬[1] 34
9 Idebenone [2] Idebenone; Raxone[1] D01750 --[6] 6, 8, 13, 18, 113, 302
10 Idursulfase [4] Elaprase; Iduronate 2-sulfatase; IDURSULFASA; IDURSULFASE[1] D04499 [1] IDS 💬[3] Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬[1] 19
11 Idursulfase beta [3] Hunterase; Iduronate 2-sulfatase; Idursulfase beta[1] D11025 [1] IDS 💬[3] Glycosaminoglycan degradation, Lysosome, Metabolic pathways 💬[1] 19
12 Ifenprodil [1] Ifenprodil[1] D08064 [3] ADRA1A,
ADRA1B,
ADRA1D 💬		[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[1] 85
13 Ifetroban [1] Ifetroban[1] D04500 [1] TBXA2R 💬[3] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Platelet activation 💬[3] 51, 86, 113
14 Ifosfamide [1] Ifosfamide[1] D00343 --[1] 34
15 Iguratimod [1] Iguratimod[1] D01146 [1] NFKB1 💬[76] AGE-RAGE signaling pathway in diabetic complications, Acute myeloid leukemia, Adipocytokine signaling pathway, Alcoholic liver disease, Alzheimer disease, Amoebiasis, Antifolate resistance, Apoptosis, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, Cocaine addiction, Coronavirus disease - COVID-19, Cytosolic DNA-sensing pathway, Diabetic cardiomyopathy, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fluid shear stress and atherosclerosis, HIF-1 signaling pathway, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, Longevity regulating pathway, MAPK signaling pathway, Measles, MicroRNAs in cancer, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prolactin signaling pathway, Prostate cancer, RIG-I-like receptor signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Salmonella infection, Shigellosis, Small cell lung cancer, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Viral carcinogenesis, Yersinia infection, cAMP signaling pathway 💬[4] 46, 51, 53, 271
16 Iloprost [2] Iloprost; Ventavis[1] D02721 [1] PTGIR 💬[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬[4] 51, 84, 85, 86
17 Imatinib [4] Gleevec; GLIVEC; Imatinib; Imatinib Mesylate[2] D01441 ,
D08066 		[3] ABL1,
KIT,
PDGFRA 💬		[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
18 Imidacloprid [0] ---[5] 19, 20, 125, 234, 326
19 Imidapril [1] Imidapril[1] D08068 [1] ACE 💬[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬[1] 67
20 Imiglucerase [3] CEREZYME; IMIGLUCERASA; IMIGLUCERASE[1] D03020 [1] GBA 💬[4] Lysosome, Metabolic pathways, Other glycan degradation, Sphingolipid metabolism 💬[1] 19
21 Imipenem [1] IMIPENEM[2] D00206 ,
D04515 		--[1] 60
22 Imiquimod [1] Imiquimod[1] D02500 [1] TLR7 💬[5] Coronavirus disease - COVID-19, Influenza A, Measles, Neutrophil extracellular trap formation, Toll-like receptor signaling pathway 💬[2] 34, 51
23 Imlifidase [2] HMED-IdeS; IdeS[1] D11470 --[2] 64, 221
24 Implitapide [1] Implitapide---[1] 79
25 Imrecoxib [1] Imrecoxib---[1] 271
26 Inclisiran [2] ALN-PCSSC; Inclisiran[1] D11931 [1] PCSK9 💬[1] Cholesterol metabolism 💬[1] 79
27 Indapamide [1] Indapamide[2] D00345 ,
D06401 		[1] SLC12A3 💬-[1] 13
28 Indian frankincense [2] Boswellia Serrata; Boswellia Serrata Extract---[1] 13
29 Indinavir [1] Indinavir[3] D00897 ,
D02861 ,
D03833 		--[1] 265
30 Indium [1] Indium---[3] 28, 84, 299
31 Indocyanine green [1] Indocyanine green[1] D01342 --[8] 22, 46, 51, 96, 235, 278, 291, 296
32 Indole [1] Indole---[1] 51
33 Indomethacin [2] INDOMETACIN; Indomethacin[3] D00141 ,
D01565 ,
D02110 		[2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[3] 225, 271, 298
34 Indopan [0] ---[4] 8, 46, 97, 321
35 Inebilizumab [2] INEBILIZUMAB; Uplizna[1] D11757 [1] CD19 💬[5] B cell receptor signaling pathway, Epstein-Barr virus infection, Hematopoietic cell lineage, PI3K-Akt signaling pathway, Primary immunodeficiency 💬[4] 11, 13, 51, 300
36 Infigratinib [1] INFIGRATINIB[1] D11589 [3] FGFR1,
FGFR2,
FGFR3 💬		[21] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, EGFR tyrosine kinase inhibitor resistance, Endocytosis, Gastric cancer, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, PI3K-Akt signaling pathway, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Signaling pathways regulating pluripotency of stem cells, Thermogenesis 💬[1] 276
37 Infliximab [6] Flixabi; Inflectra; Infliximab; Remicade; Remsima; Zessly[1] D02598 [1] TNF 💬[67] AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬[27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
38 Influenza A virus A/Brisbane/59/2007 (H1N1) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
39 Influenza A virus A/California/7/2009 (H1N1) live (attenuated) antigen [1] FluMist---[1] 299
40 Influenza A virus A/California/7/2009 X-179A (H1N1) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
41 Influenza A virus A/Perth/16/2009 (H3N2) live (attenuated) antigen [1] FluMist---[1] 299
42 Influenza A virus A/South Dakota/6/2007 (H1N1) live (attenuated) antigen [1] FluMist---[1] 299
43 Influenza A virus A/Switzerland/9715293/2013 NIB-88 (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
44 Influenza A virus A/Texas/50/2012 X-223A (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
45 Influenza A virus A/Uruguay/716/2007(H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
46 Influenza A virus A/Uruguay/716/2007(H3N2) live (attenuated) antigen [1] FluMist---[1] 299
47 Influenza A virus A/Victoria/210/2009 X-187 (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
48 Influenza A virus A/Victoria/361/2011 (H3N2) live (attenuated) antigen [1] FluMist---[1] 299
49 Influenza A virus A/Victoria/361/2011 IVR-165 (H3N2) antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
50 Influenza B virus B/Brisbane/60/2008 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
51 Influenza B virus B/Brisbane/60/2008 live (attenuated) antigen [1] FluMist---[1] 299
52 Influenza B virus B/Massachusetts/2/2012 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
53 Influenza B virus B/Massachusetts/2/2012 BX-51B antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
54 Influenza B virus B/Phuket/3073/2013 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
55 Influenza B virus B/Texas/6/2011 antigen (formaldehyde inactivated) [1] Fluzone---[2] 21, 49
56 Influenza B virus B/Wisconsin/1/2010 live (attenuated) antigen [1] FluMist---[1] 299
57 Influenza virus type A (H1N1) [1] FluMist---[1] 299
58 Influenza virus type A (H3N2) [1] FluMist---[1] 299
59 Influenza virus type B [1] FluMist---[1] 299
60 Inosine [1] Inosine[1] D00054 --[6] 2, 6, 13, 17, 85, 122
61 Inositol [1] Inositol[1] D08079 --[2] 96, 97
62 Inotersen [1] INOTERSEN[1] D10940 [1] TTR 💬[1] Thyroid hormone synthesis 💬[1] 28
63 Insulin detemir [4] Detemir; Insulin detemir; Levemir; Levemir Penfill[1] D04539 [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 299
64 Insulin glargine [1] Insulin glargine[1] D03250 [1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[1] 299
65 Insulin human [1] Human insulin[2] D00085 ,
D03230 		[1] INSR 💬[22] AMPK signaling pathway, Adherens junction, Aldosterone-regulated sodium reabsorption, Alzheimer disease, Diabetic cardiomyopathy, FoxO signaling pathway, HIF-1 signaling pathway, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, MAPK signaling pathway, Non-alcoholic fatty liver disease, Ovarian steroidogenesis, PI3K-Akt signaling pathway, Phospholipase D signaling pathway, Rap1 signaling pathway, Ras signaling pathway, Regulation of lipolysis in adipocytes, Type II diabetes mellitus, cGMP-PKG signaling pathway, mTOR signaling pathway 💬[2] 96, 156
66 Insulin-like growth factor II [0] ---[1] 19
67 Interferon alfa [1] Interferon alfa[1] D03305 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[6] 13, 25, 26, 28, 56, 96
68 Interferon alfa-2a [3] Interferon Alfa-2A; Interferon alpha-2a; Roferon-A[1] D00745 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 56
69 Interferon alfa-2b [2] Interferon alfa-2b; Interferon alpha-2B[1] D02745 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[2] 25, 34
70 Interferon beta-1a [6] AVONEX; Interferon Beta 1-A; Interferon Beta 1a; INTERFERON BETA-1A; Interferon-beta-1a; REBIF[1] D04554 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[4] 13, 26, 96, 97
71 Interferon beta-1b [7] BETAFERON; Betaseron; EXTAVIA; Interferon beta 1B; INTERFERON BETA-1B; Interferon-beta-1b; RECOMBINANT INTERFERON BETA-1B[1] D00746 [2] IFNAR1,
IFNAR2 💬		[18] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Measles, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathways in cancer, Toll-like receptor signaling pathway 💬[1] 13
72 Interferon Gamma [1] Interferon Gamma---[8] 18, 65, 85, 107, 228, 299, 301, 326
73 Interferon gamma-1b [2] ACTIMMUNE; INTERFERON GAMMA-1B[1] D00747 [2] IFNGR1,
IFNGR2 💬		[18] Chagas disease, Cytokine-cytokine receptor interaction, HIF-1 signaling pathway, Herpes simplex virus 1 infection, Inflammatory bowel disease, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Natural killer cell mediated cytotoxicity, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis 💬[7] 18, 65, 85, 228, 299, 301, 326
74 Interleukin-1 alpha, human recombinant [1] None---[13] 6, 46, 51, 65, 84, 85, 96, 97, 140, 161, 231, 271, 299
75 Interleukin-10 [0] ---[1] 46
76 Interleukin-7 [2] Interleukin-7; Recombinant human interleukin-7---[1] 25
77 Inulin [1] Inulin[1] D00171 --[2] 96, 299
78 Iodide [1] Iodide---[1] 34
79 Iodide I-123 [2] I 123; I-123---[2] 2, 6
80 Iodine [2] Iodine; Iodo[1] D00108 --[3] 28, 46, 88
81 Ioflupane I-123 [3] DaTSCAN; Ioflupane; Ioflupane I 123---[4] 2, 5, 6, 17
82 Iohexol [2] Iohexol; OMNIPAQUE[1] D01817 --[3] 19, 67, 222
83 Iopamidol [0] [1] D01797 --[1] 279
84 Ipilimumab [1] Ipilimumab[1] D04603 [1] CTLA4 💬[4] Autoimmune thyroid disease, Cell adhesion molecules, Rheumatoid arthritis, T cell receptor signaling pathway 💬[1] 159
85 Ipratropium [1] Ipratropium[1] D02212 [5] CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5 💬		[13] Alzheimer disease, Calcium signaling pathway, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬[2] 6, 86
86 Iproniazid [1] IPRONIAZID[1] D02579 [2] MAOA,
MAOB 💬		[14] Alcoholism, Amphetamine addiction, Arginine and proline metabolism, Cocaine addiction, Dopaminergic synapse, Drug metabolism - cytochrome P450, Glycine, serine and threonine metabolism, Histidine metabolism, Metabolic pathways, Parkinson disease, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[1] 6
87 Iptacopan [1] Iptacopan[1] D12251 [1] CFB 💬[3] Complement and coagulation cascades, Coronavirus disease - COVID-19, Staphylococcus aureus infection 💬[5] 61, 62, 66, 109, 222
88 IR208 [0] ---[1] 13
89 Irbesartan [2] Aprovel; IRBESARTAN[1] D00523 [1] AGTR1 💬[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬[4] 66, 167, 168, 222
90 Iron [1] Iron---[6] 18, 96, 97, 238, 254, 284
91 Iron (III) oxide adipate [1] Adipate---[2] 97, 228
92 Iron Dextran [1] Iron Dextran[1] D02141 --[4] 62, 86, 96, 97
93 Iron polymaltose [1] Fusion---[9] 11, 13, 46, 49, 69, 70, 86, 271, 299
94 Iron sucrose [1] Iron Sucrose[1] D04616 --[3] 62, 96, 97
95 Isatuximab [1] Isatuximab[1] D11050 [1] CD38 💬[7] Calcium signaling pathway, Hematopoietic cell lineage, Metabolic pathways, Nicotinate and nicotinamide metabolism, Oxytocin signaling pathway, Pancreatic secretion, Salivary secretion 💬[2] 28, 61
96 Iscalimab [1] Iscalimab[1] D11610 [1] CD40 💬[17] Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules, Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Human T-cell leukemia virus 1 infection, Intestinal immune network for IgA production, Lipid and atherosclerosis, Malaria, NF-kappa B signaling pathway, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis 💬[2] 49, 53
97 ISIS 104838 [1] ISIS 104838---[1] 46
98 Isoflurane [1] Isoflurane[1] D00545 --[1] 6
99 Isoniazid [1] Isoniazid[3] D00346 ,
D01501 ,
D02002 		--[2] 65, 254
100 Isosorbide [1] Isosorbide[1] D00347 --[1] 113
101 Isosorbide dinitrate [2] Isosorbide; ISOSORBIDE DINITRATE[1] D00516 --[1] 113
102 Isotretinoin [1] Isotretinoin[1] D00348 [2] RARA,
RARB 💬		[8] Acute myeloid leukemia, Estrogen signaling pathway, Gastric cancer, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer 💬[4] 36, 39, 159, 160
103 Isoxaflutole [1] Balance---[8] 6, 11, 13, 81, 113, 122, 149, 299
104 Isoxsuprine [2] Isoxsuprine; Isoxsuprine Hydrochloride[1] D08092 [1] ADRB2 💬[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 13
105 Isradipine [1] Isradipine[1] D00349 [4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 6
106 Istradefylline [1] ISTRADEFYLLINE[1] D04641 [1] ADORA2A 💬[7] Alcoholism, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway 💬[1] 6
107 Itacitinib [1] Itacitinib[1] D10944 [1] JAK1 💬[27] Coronavirus disease - COVID-19, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human papillomavirus infection, Influenza A, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Measles, NOD-like receptor signaling pathway, Necroptosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Signaling pathways regulating pluripotency of stem cells, Th1 and Th2 cell differentiation, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Viral carcinogenesis 💬[5] 46, 51, 60, 97, 228
108 ITI-214 [1] ITI-214---[1] 6
109 Itolizumab [1] Itolizumab---[1] 49
110 Itraconazole [2] Itraconazole; Sporanox[1] D00350 --[5] 3, 65, 96, 227, 299
111 Ivacaftor [7] IVACAFTOR; Kaftrio; Kalydeco; Orkambi; Symdeko; Symkevi; Trikafta[1] D09916 [1] CFTR 💬[8] ABC transporters, AMPK signaling pathway, Bile secretion, Gastric acid secretion, Pancreatic secretion, Tight junction, Vibrio cholerae infection, cAMP signaling pathway 💬[1] 299
112 Ixazomib [2] Ixazomib; Ninlaro[1] D10130 [1] PSMB5 💬[8] Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬[5] 13, 16, 28, 51, 61
113 Ixekizumab [2] IXEKIZUMAB; TALTZ[1] D10071 [1] IL17A 💬[6] Alcoholic liver disease, Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Inflammatory bowel disease, Rheumatoid arthritis, Th17 cell differentiation 💬[6] 36, 37, 107, 162, 269, 271