299. 嚢胞性線維症 Cystic fibrosis Clinical trials / Disease details


臨床試験数 : 1,696 薬物数 : 1,644 - (DrugBank : 272) / 標的遺伝子数 : 96 - 標的パスウェイ数 : 170

  
6 trials found
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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agemax
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PhaseCountries
1NCT02325362
(ClinicalTrials.gov)
March 17, 201510/12/2014Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the F508del MutationSingle Center, Double-blind, Randomized, Placebo-controlled, Two-period/Two-treatment Crossover, Proof-of-mechanism Study Investigating the Effect of Miglustat on the Nasal Potential Difference in Adult Patients With Cystic Fibrosis Homozygous for the F508del MutationCystic FibrosisDrug: Miglustat ; placebo;Drug: Placebo ; MiglustatAssistance Publique - Hôpitaux de ParisActelion;CRCM (Centres de Ressources et de Compétences de la Mucoviscidose)Completed18 YearsN/AAll16Phase 2/Phase 3France
2NCT00945347
(ClinicalTrials.gov)
July 200923/7/2009Does a Nasal Instillation of Miglustat Normalize the Nasal Potential Difference in Cystic Fibrosis Patients ?Does a Nasal Instillation of Miglustat Normalize the Nasal Potential Difference in Cystic Fibrosis Patients Homozygous for the F508del Mutation? A Randomized, Double Blind Placebo-controlled Study.Cystic FibrosisDrug: Miglustat;Drug: PlaceboCliniques universitaires Saint-Luc- Université Catholique de LouvainNULLCompleted14 YearsN/ABoth10Phase 2Belgium
3EUCTR2008-002352-20-BE
(EUCTR)
11/08/200817/07/2008Single center, double-blind, randomized, placebo-controlled, two-period/two-treatment crossover study investigating the effect of miglustat on the nasal potential difference in patients with cystic fibrosis homozygous for the F508del mutationSingle center, double-blind, randomized, placebo-controlled, two-period/two-treatment crossover study investigating the effect of miglustat on the nasal potential difference in patients with cystic fibrosis homozygous for the F508del mutation Cystic fibrosis homozygous for the F508del mutation
MedDRA version: 9.1;Level: LLT;Classification code 10011762;Term: Cystic fibrosis
Trade Name: Zavesca
INN or Proposed INN: miglustat
Actelion Pharmaceuticals LtdNULLNot RecruitingFemale: yes
Male: yes
Belgium
4NCT00742092
(ClinicalTrials.gov)
August 200826/8/2008Miglustat in Cystic FibrosisSingle Center, Double-blind, Randomized, Placebo-controlled, Two-period/Two-treatment Crossover Study Investigating the Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the F508del MutationCystic FibrosisDrug: miglustat;Drug: placeboActelionNULLCompleted12 YearsN/ABoth11Phase 2Belgium
5NCT00537602
(ClinicalTrials.gov)
November 200728/9/2007Miglustat / OGT 918 in the Treatment of Cystic FibrosisSingle Center, Double-blind, Randomized, Placebo-controlled, 2-period/2-treatment Crossover Study Investigating the Effect of Miglustat on the Nasal Potential Difference in Patients With Cystic Fibrosis Homozygous for the ?F508 MutationCystic FibrosisDrug: miglustat;Drug: placeboActelionNULLTerminated12 YearsN/ABoth6Phase 2Spain
6EUCTR2006-002049-35-ES
(EUCTR)
22/07/200728/05/2007Estudio unicéntrico, a doble ciego, aleatorizado y controlado con placebo, cruzado de 2 brazos, para investigar el efecto de miglustat sobre la diferencia de potencial nasal en pacientes con fibrosis quística homocigotos para la mutación ?F508Estudio unicéntrico, a doble ciego, aleatorizado y controlado con placebo, cruzado de 2 brazos, para investigar el efecto de miglustat sobre la diferencia de potencial nasal en pacientes con fibrosis quística homocigotos para la mutación ?F508 fibrosis quística
MedDRA version: 8.1;Level: LLT;Classification code 10011762;Term: Cystic fibrosis
Trade Name: Zavesca
Product Name: miglustat
Product Code: OGT 918
INN or Proposed INN: Miglustat
Other descriptive name: 1,5 (Butylimino)-1,5-dideoxy-D-glucitol
Actelion Pharmaceuticals LtdNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
25Spain