51. 全身性強皮症 Scleroderma Clinical trials / Disease details
臨床試験数 : 523 / 薬物数 : 608 - (DrugBank : 156) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 215
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04797286 (ClinicalTrials.gov) | September 20, 2021 | 11/3/2021 | Sildenafil for Early Pulmonary Vascular Disease in Scleroderma | Sildenafil for Early Pulmonary Vascular Disease in Scleroderma | Scleroderma;Mildly Elevated Pulmonary Pressures | Drug: Sildenafil;Other: Placebo | Johns Hopkins University | Louisiana State University Health Sciences Center in New Orleans | Recruiting | 18 Years | N/A | All | 30 | Phase 2 | United States |
| 2 | NCT03053739 (ClinicalTrials.gov) | December 2016 | 29/12/2016 | To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis | Randomized Controlled Trial to Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis | Associated Pulmonary Arterial Hypertension | Drug: Sildenafil 20mg and Bosentan 62.5mg;Drug: Sildenafil 20mg and Placebo | Postgraduate Institute of Medical Education and Research | NULL | Recruiting | 18 Years | N/A | All | 50 | Phase 4 | India |
| 3 | NCT01347008 (ClinicalTrials.gov) | April 2011 | 2/5/2011 | Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis | Effect of Sildenafil on the Microcirculatory Blood Flow and on the Endothelial Progenitor Cells in Patients With Systemic Sclerosis: a Randomized, Double-blind, Placebo-controlled Clinical Trial | Scleroderma, Systemic;Scleroderma, Diffuse;Scleroderma, Limited;Raynaud Phenomenon | Drug: Sildenafil citrate;Drug: Placebo (Sugar pill) | Federal University of São Paulo | Fundação de Amparo à Pesquisa do Estado de São Paulo | Completed | 18 Years | N/A | Female | 41 | Phase 3 | Brazil |
| 4 | NCT01295736 (ClinicalTrials.gov) | November 2010 | 11/2/2011 | Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDY | Evaluation of the Efficacy of Sildenafil on Time to Healing in Patients With Scleroderma and Ischaemic Digital Ulcers: a Prospective, Longitudinal, Randomized, Comparative, Double-blind, 2-parallel-arm, Placebo-controlled Study | Systemic Scleroderma | Drug: Sildenafil;Drug: placebo | University Hospital, Lille | NULL | Completed | 18 Years | N/A | Both | 84 | Phase 3 | France |
| 5 | NCT00624273 (ClinicalTrials.gov) | February 2004 | 14/2/2008 | Sildenafil for Treatment of Digital Ulcers in Patients With Systemic Sclerosis | Effect of Sildenafil on Digital Ulcers in Systemic Sclerosis | Active Digital Ulcers | Drug: Sildenafil therapy | Charite University, Berlin, Germany | NULL | Completed | 18 Years | 80 Years | Both | 17 | Phase 2 | Germany |