8. ハンチントン病 Huntington disease Clinical trials / Disease details
臨床試験数 : 229 / 薬物数 : 193 - (DrugBank : 60) / 標的遺伝子数 : 84 - 標的パスウェイ数 : 158
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | EUCTR2019-002178-30-DE (EUCTR) | 28/07/2020 | 12/06/2020 | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Not Recruiting | Female: yes Male: yes | 70 | Phase 2 | France;Canada;Poland;Denmark;Australia;Germany;United Kingdom | ||
| 2 | EUCTR2019-002178-30-FR (EUCTR) | 28/07/2020 | 28/04/2020 | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Not Recruiting | Female: yes Male: yes | 70 | Phase 2 | France;Canada;Poland;Denmark;Australia;Germany;United Kingdom | ||
| 3 | EUCTR2019-002178-30-DK (EUCTR) | 22/01/2020 | 18/09/2019 | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders MedDRA version: 20.0;Level: LLT;Classification code 10020469;Term: Huntington's chorea;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Not Recruiting | Female: yes Male: yes | 70 | Phase 2 | France;Canada;Poland;Australia;Denmark;Germany;United Kingdom | ||
| 4 | EUCTR2019-002178-30-PL (EUCTR) | 29/10/2019 | 13/08/2019 | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Not Recruiting | Female: yes Male: yes | 70 | Phase 2 | France;Canada;Poland;Denmark;Australia;Germany;United Kingdom | ||
| 5 | NCT04617860 (ClinicalTrials.gov) | September 24, 2019 | 30/10/2020 | Open-label Extension Study to Evaluate the Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease | A Multicenter, Open-label Extension Study to Evaluate the Safety, Pharmacodynamics, and Clinical Effects of WVE-120102 in Patients With Huntington's Disease | Huntington Disease | Drug: WVE-120102 | Wave Life Sciences Ltd. | NULL | Terminated | N/A | N/A | All | 36 | Phase 1/Phase 2 | Australia;Canada;Denmark;France;Germany;Poland;United Kingdom |
| 6 | EUCTR2016-005142-39-FR (EUCTR) | 09/07/2019 | 21/05/2019 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | WAVE Life Sciences Ltd | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 48 | Human pharmacology (Phase 1): yes Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): no | United States;France;Canada;Poland;Denmark;Australia;Germany;United Kingdom | ||
| 7 | EUCTR2016-005142-39-DK (EUCTR) | 26/02/2019 | 20/12/2018 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Not Recruiting | Female: yes Male: yes | 80 | Phase 1;Phase 2 | France;United States;Canada;Poland;Australia;United Kingdom;Germany;Denmark | ||
| 8 | EUCTR2016-005142-39-GB (EUCTR) | 02/08/2018 | 19/05/2017 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders ;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 48 | Human pharmacology (Phase 1): yes Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): no | France;United States;Canada;Poland;Denmark;Australia;Germany;United Kingdom | ||
| 9 | NCT03225846 (ClinicalTrials.gov) | July 17, 2017 | 17/7/2017 | Safety and Tolerability of WVE-120102 in Patients With Huntington's Disease | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients With Huntington's Disease | Huntington's Disease | Drug: WVE-120102;Drug: Placebo | Wave Life Sciences Ltd. | NULL | Terminated | 25 Years | 65 Years | All | 88 | Phase 1/Phase 2 | Australia;Canada;Denmark;France;Germany;Poland;United Kingdom |
| 10 | EUCTR2016-005142-39-DE (EUCTR) | 04/06/2019 | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 1b/2a Study of WVE-120102 Administered Intrathecally in Patients with Huntington’s Disease | Huntington’s Disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16] | Product Name: WVE-120102 Product Code: WVE-120102 INN or Proposed INN: WVE-120102 | Wave Life Sciences UK Limited | NULL | Not Recruiting | Female: yes Male: yes | 80 | Phase 1;Phase 2 | France;United States;Canada;Poland;Denmark;Australia;Germany;United Kingdom |