17. Multiple system atrophy Clinical trials / Disease details

Clinical trials : 118 / Drugs : 163 - (DrugBank : 49) / Drug target genes : 61 - Drug target pathways : 112

5 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04782830 (ClinicalTrials.gov)	February 5, 2021	1/3/2021	Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms	Use of Accelerometer for Quantification of Neurogenic Orthostatic Hypotension Symptoms	Orthostatic; Hypotension, Neurogenic;Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy; Hypotension, Parkinsonism	Device: Accelerometer;Drug: placebo pill;Drug: Midodrine or atomoxetine pill	Vanderbilt University Medical Center	NULL	Recruiting	40 Years	80 Years	All	29	N/A	United States
2	NCT04620382 (ClinicalTrials.gov)	November 9, 2020	27/10/2020	Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients	Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients	Neurogenic Orthostatic Hypotension;Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy;Parkinson Disease	Drug: Midodrine;Drug: Placebo pill;Device: Abdominal compression;Device: sham compression	Vanderbilt University Medical Center	National Heart, Lung, and Blood Institute (NHLBI)	Recruiting	40 Years	80 Years	All	31	Early Phase 1	United States
3	NCT03482297 (ClinicalTrials.gov)	March 1, 2018	22/3/2018	Automated Abdominal Binder for Orthostatic Hypotension	Randomized, Double-blind, Sham-controlled to Evaluate the Effects of an Automated Abdominal Binder in Improving Orthostatic Tolerance in Autonomic Failure Patients With Disabling Orthostatic Hypotension	Orthostatic Hypotension;Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy	Device: automated abdominal binder;Device: Sham binder;Drug: Placebo;Drug: Midodrine	Vanderbilt University Medical Center	National Heart, Lung, and Blood Institute (NHLBI)	Recruiting	40 Years	80 Years	All	31	Phase 1/Phase 2	United States
4	NCT02897063 (ClinicalTrials.gov)	September 2016	7/9/2016	Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure	The Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Aim 2 of RDCRN (Rare Diseases Clinical Research Network) Project 2	Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy;Parkinson Disease;Orthostatic Hypotension	Drug: Droxidopa;Drug: Midodrine;Drug: Placebo	Vanderbilt University Medical Center	NULL	Recruiting	40 Years	80 Years	All	34	Phase 1	United States
5	NCT02429557 (ClinicalTrials.gov)	April 2015	21/4/2015	Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure	Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure	Orthostatic Hypotension;Pure Autonomic Failure;Multiple System Atrophy;Autonomic Failure	Other: Abdominal compression;Other: Sham abdominal compression;Drug: Placebo pill;Drug: midodrine	Vanderbilt University Medical Center	National Heart, Lung, and Blood Institute (NHLBI)	Recruiting	18 Years	80 Years	All	29	Phase 1	United States