224. Purpura nephritis Clinical trials / Disease details

Clinical trials : 13 / Drugs : 42 - (DrugBank : 20) / Drug target genes : 15 - Drug target pathways : 57

2 trials found

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR2000039686	2020-12-01	2020-11-05	To evaluate the efficacy and safety of tacrolimus in the treatment of children with Henoch Schonlein purpura nephritis	A multicentre, randomized, prospective, observational study evaluating the efficacy and safety of tacrolimus in the treatment of Henoch Schonlein purpura nephritis in children at 24 weeks	Henoch Schonlein purpura nephritis	Experimental drug treatment group:Tacroximus capsule (trade name: Saifu X R), 0.1mg /kg/d, orally taken 1 hour before or 2-3 hours after meals twice a day for 24 weeks;Prednisone 1.5-2mg/kg/d was taken orally for 4 weeks and then changed to oral administration every other day for 4 weeks, gradually reducing the amount.;Control treatment group:Cyclophosphamide 8-10mg/ kg/d was given intravenously for 2 consecutive days, once every 2-4 weeks for 4 consecutive times, and once every 3 weeks for 2 consecutive times for 6 times in total.Prednisone 1.5-2mg/kg/d was taken orally with breakfast in the morning. ;	Shengjing Hospital of China Medical University	NULL	Recruiting			Both	Experimental drug treatment group:156;Control treatment group:78;	Phase 4	China
2	NCT03222687 (ClinicalTrials.gov)	September 1, 2015	7/7/2017	Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis	Off-label Use of Tacrolimus in Children With Henoch-Schönlein Purpura Nephritis: Effectiveness and Safety	Henoch-Schönlein Purpura Nephritis	Drug: tacrolimus;Drug: prednisone	Shandong University	NULL	Completed	N/A	18 Years	All	25	Phase 4	NULL