23. Prion disease Clinical trials / Disease details

Clinical trials : 4 / Drugs : 5 - (DrugBank : 2) / Drug target gene : 0 - Drug target pathway : 0

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2010-022233-28-IT (EUCTR)	20/06/2011	05/03/2012		Fatal familial insomnia: preventive treatment with doxycycline of at risk individuals - Doxycycline in FFI individuals	Subjects born between 1958 and 1969 belonging to the Treviso FFI family, tested previously for Prion D178N/129M mutation MedDRA version: 14.1;Level: SOC;Classification code 10029205;Term: Nervous system disorders;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]	Trade Name: BASSADO INN or Proposed INN: DOXYCYCLINE HYCLATE	IST. DI RICERCHE FARMACOLOG. M. NEGRI	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Italy
2	EUCTR2006-001858-27-IT (EUCTR)	21/06/2006	12/04/2007	A randomized, double-blind pilot study vs placebo for the evaluation of efficacy and tolerability of doxycline administered by oral route in patients affected by Creutzfeldt-Jakob disease. - ND	A randomized, double-blind pilot study vs placebo for the evaluation of efficacy and tolerability of doxycline administered by oral route in patients affected by Creutzfeldt-Jakob disease. - ND	Creutzfeldt-Jakob Disease. MedDRA version: 9.1;Level: LLT;Classification code 10011384;Term: Creutzfeldt-Jakob disease	Trade Name: BASSADO 10CPS 100MG INN or Proposed INN: Doxycycline	ISTITUTO NEUROLOGICO CARLO BESTA	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Italy
3	NCT00183092 (ClinicalTrials.gov)	April 2005	14/9/2005	CJD (Creutzfeldt-Jakob Disease) Quinacrine Study	Novel Therapeutics For Prion Diseases: A Randomized, Double-blinded, Placebo-controlled Study of the Efficacy of Quinacrine in the Treatment of Sporadic Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease	Drug: Quinacrine;Drug: Placebo	University of California, San Francisco	National Institute on Aging (NIA)	Completed	18 Years	N/A	All	69	Phase 2	United States
4	NCT00104663 (ClinicalTrials.gov)	June 2004	3/3/2005	PRION-1: Quinacrine for Human Prion Disease	PRION-1: Quinacrine for Human Prion Disease. A Partially Randomized Patient Preference Trial to Evaluate the Activity and Safety of Quinacrine in Human Prion Disease	Prion Disease	Drug: Quinacrine	Medical Research Council	NULL	Completed	12 Years	N/A	Both	160	N/A	United Kingdom