25. Progressive multifocal leukoencephalopathy Clinical trials / Disease details
Clinical trials : 25 / Drugs : 35 - (DrugBank : 21) / Drug target genes : 8 - Drug target pathways : 37
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05236777 (ClinicalTrials.gov) | January 1, 2019 | 2/2/2022 | TOPIK Study: A Study to Report Progressive Multifocal Leukoencephalopathy and Other Serious Opportunistic Infections in Natalizumab Treated Participants | Long-term Surveillance of Patients With Multiple Sclerosis to Report Progressive Multifocal Leukoencephalopathy and Other Serious Opportunistic Infections Among Patients Treated With Natalizumab | Multiple Sclerosis | Drug: Natalizumab | Biogen | Association for Functional Rehabilitation, Recreation and Applied Kinesiology Impulse | Recruiting | N/A | N/A | All | 600 | Czechia | |
| 2 | NCT01970410 (ClinicalTrials.gov) | October 2013 | 22/10/2013 | Sub-Study: Analysis of JCV Antibody Index in MS Patients Treated With Teriflunomide - SWITCH-JCV | Switching Relapsing Multiple Sclerosis Patients Treated With Natalizumab at Risk for Progressive Multifocal Leukoencephalopathy to Teriflunomide: Is This Safe and Effective? (Sub-study: SWITCH-JCV) | Multiple Sclerosis | Drug: teriflunomide | Providence Health & Services | Multiple Sclerosis Center of Northeastern New York | Active, not recruiting | 21 Years | 60 Years | All | 41 | Phase 4 | United States |
| 3 | EUCTR2010-020369-26-DE (EUCTR) | 29/11/2010 | 18/08/2010 | High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab | High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab | Immune Reconstitution Inflammatory Syndrome MedDRA version: 12.1;Level: PT;Classification code 10054014;Term: Immune reconstitution syndrome | Product Name: methylprednisolone INN or Proposed INN: METHYLPREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE Product Name: prednisolone INN or Proposed INN: PREDNISOLONE | Biogen Idec | NULL | Not Recruiting | Female: yes Male: yes | 20 | Germany | |||
| 4 | NCT01211665 (ClinicalTrials.gov) | September 2010 | 29/7/2010 | Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) | High-Dose Corticosteroids for Immune Reconstitution Inflammatory Syndrome in Patients Who Develop Progressive Multifocal Leukoencephalopathy on Natalizumab | Immune Reconstitution Inflammatory Syndrome;Leukoencephalopathy, Progressive Multifocal | Drug: Methylprednisolone;Drug: Prednisolone | Biogen | Elan Pharmaceuticals | Terminated | 18 Years | N/A | All | 3 | Phase 4 | United States;Germany |