Ixazomib ( DrugBank: Ixazomib )
4 diseases
| 告示番号 | 疾患名（ページ内リンク） | 臨床試験数 |
|---|---|---|
| 13 | 多発性硬化症／視神経脊髄炎 | 1 |
| 16 | クロウ・深瀬症候群 | 1 |
| 28 | 全身性アミロイドーシス | 4 |
| 51 | 全身性強皮症 | 1 |
13. 多発性硬化症／視神経脊髄炎
臨床試験数 : 3,342 / 薬物数 : 2,355 - (DrugBank : 406) / 標的遺伝子数 : 269 - 標的パスウェイ数 : 241
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT03783416 (ClinicalTrials.gov) | June 1, 2019 | 10/12/2018 | SIZOMUS Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis | Safety of Ixazomib Targeting Plasma Cells in Multiple Sclerosis: A Phase 1b Randomised, Double-blind, Placebo-controlled Trial. | Relapsing Remitting Multiple Sclerosis;Primary Progressive Multiple Sclerosis;Secondary Progressive Multiple Sclerosis | Drug: Ixazomib (NINLARO®) capsules / Matching placebo capsules | Queen Mary University of London | Takeda Pharmaceuticals International, Inc. | Not yet recruiting | 18 Years | 65 Years | All | 72 | Phase 1 | United Kingdom |
16. クロウ・深瀬症候群
臨床試験数 : 13 / 薬物数 : 18 - (DrugBank : 8) / 標的遺伝子数 : 5 - 標的パスウェイ数 : 81
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT02921893 (ClinicalTrials.gov) | October 31, 2016 | 26/9/2016 | Ixazomib Citrate, Lenalidomide, and Dexamethasone in Treating Patients With POEMS Syndrome | Ixazomib, Lenalidomide, and Dexamethasone for Patients With POEMS Syndrome | Plasmacytoma;POEMS Syndrome | Drug: Dexamethasone;Drug: Ixazomib Citrate;Drug: Lenalidomide;Other: Questionnaire Administration | Mayo Clinic | National Cancer Institute (NCI) | Recruiting | 18 Years | N/A | All | 34 | Phase 2 | United States |
28. 全身性アミロイドーシス
臨床試験数 : 261 / 薬物数 : 276 - (DrugBank : 81) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 178
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04847453 (ClinicalTrials.gov) | September 14, 2021 | 15/4/2021 | Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis | A Phase 1/1a Study of Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for Relapsed/Refractory Light Chain Amyloidosis | Recurrent AL Amyloidosis;Refractory AL Amyloidosis | Procedure: Bone Marrow Aspiration and Biopsy;Drug: Dexamethasone;Drug: Ixazomib Citrate;Drug: Venetoclax | National Cancer Institute (NCI) | NULL | Recruiting | 18 Years | N/A | All | 6 | Phase 1 | United States |
| 2 | NCT03618537 (ClinicalTrials.gov) | August 2, 2018 | 2/8/2018 | Ixazomib Maintenance Study in Patients With AL Amyloidosis | Ixazomib Maintenance Following Initial Therapy in Patients With Immunoglobulin Light Chain (AL) Amyloidosis | AL Amyloidosis | Drug: Ixazomib;Drug: Dexamethasone | Memorial Sloan Kettering Cancer Center | Tufts Medical Center;Vanderbilt University Medical Center | Recruiting | 18 Years | N/A | All | 47 | Phase 2 | United States |
| 3 | NCT03283917 (ClinicalTrials.gov) | February 7, 2018 | 13/9/2017 | Daratumumab, Ixazomib, and Dexamethasone in AL Amyloidosis | A Safety Study of Daratumumab, Ixazomib, and Dexamethasone in AL Amyloidosis | Newly Diagnosed Primary Amyloidosis;Recurrent Primary Amyloidosis;Refractory Primary Amyloidosis | Biological: Daratumumab;Drug: Dexamethasone;Drug: Ixazomib | M.D. Anderson Cancer Center | Janssen Pharmaceuticals;Takeda Pharmaceutical | Recruiting | 18 Years | N/A | All | 20 | Phase 1 | United States |
| 4 | NCT03236792 (ClinicalTrials.gov) | June 12, 2017 | 20/7/2017 | Ixazomib In Combination With Cyclophosphamide And Dexamethasone for Newly Diagnosed AL Amyloidosis | Phase 1/2 Study Of Ixazomib In Combination With Cyclophosphamide And Dexamethasone In Patients With Newly Diagnosed Immunoglobulin Light Chain AL Amyloidosis | AL Amyloidosis | Drug: Ixazomib;Drug: Cyclophosphamide;Drug: Dexamethasone | Icahn School of Medicine at Mount Sinai | Millennium Pharmaceuticals, Inc. | Recruiting | 18 Years | N/A | All | 30 | Phase 1/Phase 2 | United States |
51. 全身性強皮症
臨床試験数 : 523 / 薬物数 : 608 - (DrugBank : 156) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 215
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04837131 (ClinicalTrials.gov) | April 28, 2021 | 5/4/2021 | A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients | A Phase 2 Open-Label Pilot Study of the Safety and Tolerability of Ixazomib Administered Orally to Patients With Scleroderma-Related Interstitial Lung Disease | Systemic Sclerosis;Scleroderma;Diffuse Systemic Sclerosis;Diffuse Scleroderma;Diffuse Cutaneous Systemic Sclerosis;Diffuse Cutaneous Scleroderma;Progressive Systemic Sclerosis;Progressive Scleroderma;Scleroderma, Systemic;Scleroderma, Diffuse;Progressive;Systemic Sclerosis, Diffuse;Systemic; Sclerosis, Progressive;Scleroderma of Lung;Scleroderma With Pulmonary Involvement;Systemic Sclerosis Pulmonary;Systemic Sclerosis With Lung Involvement;Interstitial Lung Disease;Pulmonary Fibrosis Interstitial | Drug: Ixazomib | W. Leroy Griffing | NULL | Recruiting | 18 Years | N/A | All | 12 | Phase 2 | United States |